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| 1 | p53 modifications:exquisite decorations ofthe powerful guardian显示文摘The last 40 years have witnessed how p53 rose from a viral binding protein to a central factor in both stress responses and tumor suppression.The exquisite regulation of p53 functions is of vital importance for cell fate decisions.Among the multiple layers of mechanisms controlling p53 function,posttranslational modifications (PTMs) represent an efficient and precise way.Major p53 PTMs include phosphorylation,ubiquitination,acetylation,and methylation.Meanwhile,other PTMs like sumoylation,neddylation,O-GlcNAcylation,adenosine diphosphate (ADP)-ribosylation,hydroxylation,and p-hydroxybutyrylation are also shown to play various roles in p53 regulation.By independent action or interaction,PTMs affect p53 stability,conformation,localization,and binding partners.Deregulation of the PTM-related pathway is among the major causes of p53-associated developmental disorders or diseases,especially in cancers.This review focuses on the roles of different p53 modification types and shows how these modifications are orchestrated to produce various outcomes by modulating p53 activities or targeted to treat different diseases caused by p53 dysregulation. | Yanqing Liu Omid Tavana Wei Gu | 2019 | Journal of Molecular Cell Biology2019，11，7： | 24 |
| 2 | Autonomous vehicles: challenges, opportunities, and future implications for transportation policies显示文摘This study investigates the challenges and opportunities pertaining to transportation policies that may arise as a result of emerging autonomous vehicle(AV)technologies. AV technologies can decrease the transportation cost and increase accessibility to low-income households and persons with mobility issues. This emerging technology also has far-reaching applications and implications beyond all current expectations. This paper provides a comprehensive review of the relevant literature and explores a broad spectrum of issues from safety to machine ethics. An indispensable part of a prospective AV development is communication over cars and infrastructure(connected vehicles). A major knowledge gap exists in AVtechnology with respect to routing behaviors. Connectedvehicle technology provides a great opportunity to implement an efficient and intelligent routing system. To this end, we propose a conceptual navigation model based on a fleet of AVs that are centrally dispatched over a network seeking system optimization. This study contributes to the literature on two fronts:(i) it attempts to shed light on future opportunities as well as possible hurdles associated with AV technology; and(ii) it conceptualizes a navigation model for the AV which leads to highly efficient traffic circulations. | Saeed Asadi Bagloee Madjid Tavana Mohsen Asadi Tracey Oliver | 2016 | Journal of Modern Transportation2016，24，4： | 14 |
| 3 | Modulation of the p53/MDM2 interplay by HAUSP inhibitors显示文摘p53 和 MDM2 是其稳定性紧通过调停 ubiquitination 的降级被控制的短命蛋白质,这很好被建立。尽管众多的研究显示 MDM2 E3 ligase 活动,以及在 p53 和 MDM2 之间的蛋白质蛋白质相互作用,是为这条规定的主要焦点,新兴的证据建议 deubiquitinase 联系 herpesvirus 的 ubiquitin 特定的朊酶(HAUSP,也作为 USP7 知道) 起一个关键作用。而且, HAUSP 抑制提高 p53 稳定性和力量为治疗学的目的是有益的。在这评论,我们讨论这条动态小径的进展和影响 HAUSP 活动的积极、否定的管理者的贡献。我们也在认为 HAUSP 禁止者的第一代的生产正当的癌症加亮 HAUSP 的角色。 | Omid Tavana Wei GU | 2017 | Journal of Molecular Cell Biology2017，9，1： | 10 |
| 4 | Modeling of bentonite/sepiolite plastic concrete compressive strength using artificial neural network and support vector machine显示文摘Plastic concrete is an engineering material,which is commonly used for construction of cut-offwalls to prevent water seepage under the dam.This paper aims to explore two machine learning algorithms including artificial neural network (ANN)and support vector machine (SVM)to predict the compressive strength of bentonite/sepiolite plastic concretes.For this purpose,two unique sets of 72 data for compressive strength of bentonite and sepiolite plastic concrete samples (totally 144 data)were prepared by conducting an experimental study.The results confirm the ability of ANN and SVM models in prediction processes.Also,Sensitivity analysis of the best obtained model indicated that cement and silty clay have the maximum and minimum influences on the compressive strength,respectively.In addition, investigation of the effect of measurement error of input variables showed that change in the sand content (amount)and curing time will have the maximum and minimum effects on the output mean absolute percent error (MAPE)of model, respectively.Finally,the influence of different variables on the plastic concrete compressive strength values was evaluated by conducting parametric studies. | Ali Reza GHANIZADEH Hakime ABBASLOU Amir Tavana AMLASHI Pourya ALIDOUST | 2019 | Frontiers of Structural and Civil Engineering2019，13，1： | 3 |
| 5 | The role of FasFas L signaling pathway in induction of apoptosis in patients with sulfur mustard-induced chronic bronchiolitis显示文摘 | Pirzad G Jafari M Tavana S Sadrayee H Ghavami S Shajiei A | 2010 | J Toxicol2010，2010，37： | 1 |
| 6 | 显示文摘 | Tavana A Randolph A D | 1989 | AIChE1989，35，10： | 1 |
| 7 | Novel copper-exchanged titanosilicate adsorbent for low temperature H 2 S removal显示文摘 | Rezaei S Tavana A Sawada J A | 2012 | Ind Eng Chem Res2012，51，12： | 1 |
| 8 | Euclid: strategic altemative assessment matrix 显示文摘 | TAVANA M | 2002 | Journal of Multi-criteria Decision Analysis2002，11，2： | 1 |
| 9 | Euclid:strategic alternative assessment matrix显示文摘 | | 2002 | Journal of multi-criteria decision analysis:2002，11，2： | 1 |
| 10 | Interpretation of contact an- gle measurements on two different fluoropolymers for the determi- nation of solid surface tension显示文摘 | Tavana H Simon F Grundke K | 2005 | Journal of Colloid and Interface Science2005，291，2： | 1 |
| 11 | Targeting the molecular chaperone heat shock protein 90 (HSP90) :lessons learned and fu- ture directions显示文摘 | HONG D BANERJI U TAVANA B | 2013 | Cancer Treat Rev2013，39，4： | 1 |
| 12 | Targeting the molecular chaperone heat shock protein 90 (HSPg0): Lessons learned and future directions显示文摘 | Hong DS Banel'ji U Tavana B | 2012 | Cancer Treat Rev2012，，： | 1 |
| 13 | Giving samoan healers credit for prostratin显示文摘 | Cox PA Johnson HE Tavana G | 2008 | Science2008，320，5883： | 1 |
| 14 | Determining three-dimensional non-spherical critical slip surface in earth slopes using an optimization method显示文摘 | Hajiazizi M Tavana H | 2013 | Engineering Geology2013，153，1： | 1 |
| 15 | Interpretation of con- tact angle measurements on two different fluoropolymers for the determination of solid surface tension 显示文摘 | Tavana H Simon F Grundke K | 2005 | J Colloid Inter- face Sci2005，291，2： | 1 |
| 16 | A New Multi- objective Particle Swarm Optimization Method for Solving Reliability Redundancy Allocation Problems 显示文摘 | Kaveh K D Abtahi A R Tavana M | 2013 | Reliability Engineering and System Safety2013，111，： | 1 |
| 17 | A Hybrid Delphi- SWOT Paradigm for Oil and Gas Pipeline Strategic Planning in Caspian Sea Basin显示文摘 | Tavana M Pirdashti M Kennedy D T | 2012 | Energy Policy2012，40，1： | 1 |
| 18 | A new molecularly imprinted polymer (MIP)-based electrochemical sensor for monitoring 2,4,6-trinitrotolu- ene(TNT) in natural waters and soil samples 显示文摘 | Alizadeh T Ganjali M R Zare M Norouzi P Tavana B | 2010 | Bio- sensors & Bioelectronics2010，25，5： | 1 |
| 19 | A meth- odology for selecting portfolios of projects with interactions and under uncertainty 显示文摘 | Ghapanchi A H Tavana M Khakbaz M H | 2012 | International Journal of Project Management2012，30，7： | 1 |
| 20 | Strategic Assessment Model:A Multiple Criteria Decision Support System for Evaluation of Strategy Alternatives显示文摘 | Tavana M Banerjee S | 1995 | Decision Science1995，26，1： | 1 |
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