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| 1 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 2 | ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease. | Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde | 2014 | World Journal of Gastroenterology2014，20，10： | 2 |
| 3 | Indocyanine green elimination test in orthotopic liver recipients显示文摘 | T Tsubono S Todo N Jabbour A Mizoe V Warty AJ Demetris TE Starzl | 1996 | Hepatology1996，，5： | 2 |
| 4 | Role of genotype in the cycle of violence in maltreated children显示文摘 | Caspi A McClay J Moffitt TE | 2002 | Science2002，297，5582： | 1 |
| 5 | p75NTR-live or let die显示文摘 | Nykjaer A Willnow TE Petersen CM | 2005 | Curt Opin Neurobiol2005，15，1： | 1 |
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| 7 | Comparison of HPLC and capillary electrophoresis for confirmatory testing of the alcohol misuse marker carbohydrate-deficient transferrin显示文摘 | Helander A Wielders JP Te SR Bergstrom JP | 2005 | Clin Chem2005，51，8： | 1 |
| 8 | Surgical approach to hysterectomy for benign gynaecological disease显示文摘 | Nieboer TE Johnson N Lethaby A | 2009 | Cochrane Database Syst Rev2009，8，00： | 1 |
| 9 | Comparison of fractional Inhibitory concentration index with response surface modeling for characterization of in vitro interaction of antifungals against itraconazole-susceptible and -resistant asporgillus fumigatus isolates 显示文摘 | TE DORSTHORST D T A VERWEIJ P E MEIS J F G M | 2002 | Antimicrob Agents Chemother2002，46，3： | 1 |
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| 11 | Indications of philadelphia collar in the treatment of upper cervical injuries显示文摘 | Cosan TE Tel E Arslantas A | 2001 | Eur J Emerg Med2001，8，1： | 1 |
| 12 | Low self-control,social bonds,and crime:social causation,social selection,or both显示文摘 | Wright BRE Caspi A Moffitt TE | 1999 | Criminology1999，37，： | 1 |
| 13 | Immunologic and virologic response to highly active antlretroviral therapy in the multicenter AIDS cohort study显示文摘 | Yamashita TE Phair JP Munoz A | 2001 | AIDS2001，15，6： | 1 |
| 14 | Current insights into ocular graft-versus-host disease 显示文摘 | Riemens A te Boome L Imhof S | 2010 | Curt Opin Ophthalmol2010，21，6： | 1 |
| 15 | Influence of life stress on de-pression:moderation by a polymorphism in the 5-HTT gene显示文摘 | Caspi A Sugden K Moffitt TE | 2003 | Science2003，301，5631： | 1 |
| 16 | Critical appraisal ofthe current practice in murine TNBS-induced colitis显示文摘 | te VeIde A A Verstege M I Hommes D W | 2006 | Inflamm Bowel Dis2006，12，10： | 1 |
| 17 | Effect of genetic variants of the heart fatty acid-binding protein gene on intramuscular fat and performan-ce traits in pigs显示文摘 | A J van Erp F L Hardem F J Verburg T H Meuwissen J HVeerkamp and M F te Pas | | 0，，04： | 1 |
| 18 | Study on composites of Nylon-6 with hollow glass microspheres显示文摘 | Te N K Addink R Van der Vegt A K | 1989 | Polymer Bulletin (Berlin)1989，21，5： | 1 |
| 19 | Inflammatory signal transduction in Crohn's disease and novel therapeutic approaches显示文摘 | Van Montfrans C Peppelenbosch M Te Velde A A | 2002 | Biochem Pharmacol2002，64，： | 1 |
| 20 | Mitochon-drial nitric oxide synthase-a ubiquitous regulator of oxidative phosphorylation显示文摘 | Bates TE Loesch A Burnstock G | 1996 | Biochem Biophys Res Commun1996，218，： | 1 |
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