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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | The physcomitrella genome reveals evolutionary insights into the conquest of land by plants 显示文摘 | Rensing S A Lang D Zimmer A D Terry A Salamov A Shapiro H Nishiyama T Perroud P F Lindquist E A Kamisugi Y | 2008 | Science2008，319，5859： | 1 |
| 4 | Postoperative irradiation of minor salivary gland malignancies of the head and neck显示文摘 | Le Q T Birdwell S Terris D J | 1999 | Radiother Oncol1999，52，2： | 1 |
| 5 | The efficacy of spinosad againstthe western flower thrips, Frankliniella occidentalis, and its impact on associated biological control agents on greenhouse cucumbers in southern Ontario显示文摘 | Terri J Cynthia S D Ron H | 2005 | Pest Management Science2005，61，： | 1 |
| 6 | Farside Bus Stops are Better显示文摘 | TERRY D S THOMAS G J | 1971 | Traffic Engineering1971，41，3： | 1 |
| 7 | 75 keV, 140 mA proton injector显示文摘 | JOSEPH D S TERRY L F LASH D H | 2002 | Review of Scientific Instruments2002，73，2： | 1 |
| 8 | Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing 显示文摘 | Pflueger D Terry S Sboner A | 2011 | Genome Res2011，21，1： | 1 |
| 9 | 显示文摘 | Azibuke D C Chrysanthou A | 1994 | Scand J Metall1994，23，3： | 1 |
| 10 | Sensors and Actuators显示文摘 | Allen H V Terry S C De Bruin D W | 1989 | 20:153-1611989，20，： | 1 |
| 11 | Interaction Effects inthe Theory of Planned Behavior:The Interplay of Self-Identityand Past Behavior显示文摘 | Smith J R Terry D J Manstead A S R | 2007 | Journal of Applied Social Psychology2007，37，11： | 1 |
| 12 | Independent associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with blood pressure among US adults显示文摘 | Guixiang Zhao Earl S Ford Chaoyang Li Penny M Kris-Etherton Terry D Etherton Lina S Balluz | 2010 | Journal of Hypertension2010，，9： | 1 |
| 13 | Determination of carbaryl in honeybees and pollen by HPLC显示文摘 | Terry D S Rocco A M George W H | 1986 | Chromatography1986，352，： | 1 |
| 14 | 显示文摘 | Azibuke D C Chrysanthou A | 1994 | J Mater Science1994，29，16： | 1 |
| 15 | Synchronization of chaos in an array of three lasers显示文摘 | Terry J R Thornburg K S Deshazer D J | 1999 | Phys Rev E1999，59，4： | 1 |
| 16 | Yield models implied by traditional fertilizer recommendations and a framework for including nontra- ditional information 显示文摘 | Terry L K John P S Kevin C D | 2003 | Soil Sci Soc Am J2003，67，： | 1 |
| 17 | Looking forward but learning from our past; Potential challenges to developing authentic leadership theory and authentic leaders显示文摘 | Cecily D C Terri A S Chester A S | 2005 | The Leadership Quarterly2005，16，： | 1 |
| 18 | Intraocular lens implantation in the absence of capsular support显示文摘 | Michael D Wagoner Terry A Cox Reginald George Ariyasu Deborah S Jacobs Carol L Karp | 2003 | Ophthalmology2003，，4： | 1 |
| 19 | Exploring consumer motivations for creating user-generated content 显示文摘 | Terry D Eastin M S Bright L | 2008 | Jour- nal of Interactive Advertising2008，8，2： | 1 |
| 20 | Effect of polyacrylamide and irrigation method soil physical properties显示文摘 | Terry R E Nelson S D | 1986 | Soil Sci1986，141，5： | 1 |
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