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| 1 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 2 | On the construction of a strongly con- nected broadcast arborescence with bounded transmission delay显示文摘 | L1 Y S THAI M T WU F | 2006 | IEEE Transactions on Mobile Computing2006，5，10： | 1 |
| 3 | Preoperative portal embolization to increase safety of major hepateetomy for hilar bile duet carcinomar a preliminary report 显示文摘 | Makuuchi M Thai BL Takayasu K | 1990 | Surgery1990，107，5： | 1 |
| 4 | ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1 显示文摘 | Thai M Ting PYj McLaughlin J | 2011 | Leukemia2011，25，2： | 1 |
| 5 | Protein-Protein Interaction and Group Testing in Bipartite Graphs显示文摘 | Li Ying-shu Thai M T Liu-Zhen Wu Wei-li | 2005 | Bioinformatics Research and Applications2005，1，： | 1 |
| 6 | Sol particle immunoassay (SPIA)显示文摘 | Leuvering J H Thai P J van der Waart M | 1980 | Immunoassay1980，1，1： | 1 |
| 7 | ADAMTS1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells显示文摘 | Krampert M Kuenzle S Thai SN | 2005 | J Biol Chem2005，280，23： | 1 |
| 8 | On Approximation Algorithms of k-connected m-dominating Sets in Disk Graphs显示文摘 | Thai M Zhang Ning Tiwari R | 2007 | Theoretical Computer Science2007，385，13： | 1 |
| 9 | preoperative portal em- bolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report 显示文摘 | Makuuchi M Thai BL Takayasu K | 1990 | Surgery1990，107，5： | 1 |
| 10 | The effect of the degree of hydrolysis of the PVA and the plasticizer concentration on the color,opacity,and thermal and mechanical properties of films based on PVA and gelatin blends显示文摘 | Maria Thais M C Carvalho Rosemary A de Sobral Paulo J A | | 0，，02： | 1 |
| 11 | Social capital,networks, trust and immi-grant entrepreneurship : A cross -country analysis 显示文摘 | Turkina E Thai M T T | 2013 | Journal ofEnterprising Communities : People and Places in the Global Econo-my2013，7，2： | 1 |
| 12 | Detection of local community structures in complex dynamic networks with random walks显示文摘 | Thakur G S Tiwari R Thai M T | 2009 | IET Systems Biology2009，3，4： | 1 |
| 13 | Occurrence of trichothecene mycotoxins in Brazilian corn-based food products显示文摘 | THAIS V M LUCIA M V BAPTISTA G G | 2006 | Food Control2006，17，： | 1 |
| 14 | Preoperative portal emtmlization to inerease safety of major hepatectomy for hilar bile duct carcinoma: a preliminary reporl 显示文摘 | Makuuchi M Thai BL Takayasu K | 1990 | Surgery1990，107，5： | 1 |
| 15 | Pioglitazone reduces secondary brain damage afte~ experimental brain trauma by PPAR-~/-independent mechanisms显示文摘 | Thai S C I-leinetmnn M hth C | 2011 | J Neurotrauma2011，28，6： | 1 |
| 16 | Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report显示文摘 | Makuuchi M Thai BL Takayasu K | 1990 | Surgery1990，107，5： | 1 |
| 17 | Effect of different coating treatments on the quality of mango fruit显示文摘 | THAI T H DUCAMP M N LEBRUN M | 2002 | Journal of Food Quality2002，25，6： | 1 |
| 18 | On Greedy Construction of Connected Dominating Sets in Wireless Networks显示文摘 | Li Yingshu Thai M T Wang Feng | 2005 | Wireless Communications and Mobile Computing2005，5，8： | 1 |
| 19 | Coverage problems in wireless sensor networks:designs and analysis显示文摘 | THAI M T WANG F DU D Z | 2008 | International Journal of Sensor Networks2008，3，3： | 1 |
| 20 | preoperative portal emblization to increase safety of major hepatectomy for hilar bile duct carcinoma:a preliminary report显示文摘 | Makuuchi M Thai B L Takayasu K | 1990 | Surgery1990，107，5： | 1 |
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