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| 1 | Outcomes of severe sepsis and septic shock patients after stratifi cation by initial lactate value显示文摘BACKGROUND: In the setting of severe sepsis and septic shock, mortality increases when lactate levels are ≥ 4 mmol/L. However, the consequences of lower lactate levels in this population are not well understood. The study aimed to determine the in-hospital mortality associated with severe sepsis and septic shock when initial lactate levels are < 4 mmol/L.METHODS: This is a retrospective cohort study of septic patients admitted over a 40-month period. Totally 338 patients were divided into three groups based on initial lactate values. Group 1 had lactate levels < 2 mmol/L; group 2: 2–4 mmol/L; and group 3: ≥ 4 mmol/L. The primary outcome was in-hospital mortality.RESULTS: There were 111 patients in group 1, 96 patients in group 2, and 131 in group 3. The mortality rates were 21.6%, 35.4%, and 51.9% respectively. Univariate analysis revealed the mortality differences to be statistically significant. Multivariate logistic regression demonstrated higher odds of death with higher lactate tier group, however the findings did not reach statistical significance.CONCLUSION: This study found that only assignment to group 3, initial lactic acid level of ≥ 4 mmol/L, was independently associated with increased mortality after correcting for underlying severity of illness and organ dysfunction. However, rising lactate levels in the other two groups were associated with increased severity of illness and were inversely proportional to prognosis. | Kimberly A. Chambers Adam Y. Park Rosa C. Banuelos Bryan F. Darge Bindu H. Akkanti Annamaria Macaluso Manoj Thangam Pratik B. Doshi | 2018 | World Journal of Emergency Medicine2018，9，2： | 26 |
| 2 | Development of turbulence models for shear flows by a double expansion technique 显示文摘 | YAKHOT V ORSZAG S A THANGAM S GATSKI T B SPEZIALE C G | 1992 | Physics of Fluids A1992，4，7： | 1 |
| 3 | Analysis of an RNG based tur-bulence model for separated flows显示文摘 | Speziale C G Thangam S | 1992 | International Jour- nal of Engineering Science1992，30，10： | 1 |
| 4 | Application of alkaline protease isolated from alcaligenes faecalis for enzymatic unhaifing in tanneries 显示文摘 | Berla Thangam E Nagarajan T Suseela Rajkumar G | 2001 | JALCA2001，96，： | 1 |
| 5 | Development of turbulence models for shear flows by a double expan- sion technique 显示文摘 | Yakhot V Orszag S A Thangam S | 1992 | Phys Fluids1992，，7： | 1 |
| 6 | Performance of gerbera varieties in different growing media under coastal humid conditions of Goa显示文摘 | THANGAM M LADANIYA MS KO-RIKANTHIMATH VS | 2009 | Indian Journal of Horticul-ture2009，66，1： | 1 |
| 7 | Purification and characterization of alkaline protease from Alcaligenes faecalis 显示文摘 | Thangam B E Rajkumar G S | 2002 | Biotechnology and Applied Biochemistry2002，35，： | 1 |
| 8 | Application of alkaline protease isolated from alcaligenes facecails for en- zymatic unhairing in tanneries 显示文摘 | Thangam E B Nagarajan T Rajjkumar G S | 2001 | Jour- nal of the American Leather Chemists As- sociation2001，96，4： | 1 |
| 9 | Analysis of a RNG based turbulence model for separated flows 显示文摘 | SPEZIALE C G THANGAM S | 1992 | International Journal of Engineering Science1992，30，10： | 1 |
| 10 | Application of alkaline protease isolated from alcaligenes faecalis for enzymatic unhairing in tanneries 显示文摘 | Thangam E B Nagarajan T Rajkumar G S | 2001 | JALCA2001，96，4： | 1 |
| 11 | Development of turbulent models for shear flows by a double expansion technique 显示文摘 | Yhkhot V Orszag S A Thangam S | 1992 | Physics of fluids A1992，4，7： | 1 |
| 12 | Deve-lopment of turbulence models for shear flows by a double expansion technique显示文摘 | Yakhot V Orszag S A Thangam S | 1992 | Physics of Fluids1992，4，： | 1 |
| 13 | Analysis of an RNG Based Turbulence Model for Separated Flows显示文摘 | Speziale C G Thangam S | 1992 | International Journal of Engineering Science1992，30，10： | 1 |
| 14 | Oxali- platin - chitosan nanopartieles induced intrinsic apoptotic signa- ling pathway:A 'smart' drug delivery system to breast cancer cell therapy显示文摘 | Raju Vivek Ramar Thangam Varukattu Nipunbabu | 2014 | Int J Biol Macromo12014，65，： | 1 |
| 15 | Analysis of RNG based turbu lence model for separated flows 显示文摘 | Speziale C G Thangam S | 1992 | Int J Engng Sci1992，，10： | 1 |
| 16 | Development of turbulence models for shear flows by a double expansion tech- nique显示文摘 | Yakhot V Orszag S A Thangam S | 1992 | Physics of Fluids1992，4，7： | 1 |
| 17 | Development of turbulence models for shear flows by a double expansion technique 显示文摘 | Yakhot V Orszag S A Thangam S | 1992 | Physics of Fluids A1992，4，7： | 1 |
| 18 | Simulation and analysis of rigidlfoil electrolytic in-process dressing (ELID) ayatema for grinding显示文摘 | ZHU Z Q WANG X H THANGAM S | 2004 | Journal of Manufacturing Science and Engineering2004，126，8： | 1 |
| 19 | Analysis of an RNG based turbulence model for separated flows显示文摘 | Spezial C G Thangam S | 1992 | International Journal of Engineering Science1992，30，10： | 1 |
| 20 | Development and analysis of foil electrodes for high speed electrolytic in-process wheel dressing显示文摘 | ZHU Z Q LIU X M THANGAM S | 2003 | Machining Science and Technology2003，7，1： | 1 |
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