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| 1 | Differences in atheroma between Caucasian and Asian subjects with anterior stroke:A vessel wall MRI study显示文摘Background and purpose While extracranial carotid artery stenosis is more common among Caucasians and intracranial artery stenosis is more common among Asians,the differences in atherosclerotic plaque characteristics have not yet been extensively examined.We sought to investigate plaque location and characteristics within extracranial carotid and intracranial arteries in symptomatic Caucasians and Chinese using vessel wall MRI.Methods Subjects with recent anterior circulation ischaemic stroke were recruited and imaged at two sites in the USA and China using similar protocols.Both extracranial carotid and intracranial arteries were reviewed to determine plaque location and characteristics.Results The prevalence of extracranial carotid plaque in Caucasians and Chinese was 73.1%and 49.1%,respectively(p=0.055).Prevalence of intracranial plaque was 38.5%and 69.1%in Caucasians and Chinese,respectively(p=0.02).Furthermore,42% of Caucasians and 16%of Chinese had high-risk plaque(HRP)features(intraplaque haemorrhage,luminal surface disruption)in the extracranial carotid artery(p=0.03).The prevalence of HRP features in intracranial arteries was not significantly different between the two cohorts(4%vs 11%;p=0.42).Conclusions Differences in the location and characteristics of cerebrovascular atherosclerosis were identified by vessel wall MRI in US Caucasian and Chinese subjects with recent anterior circulation ischaemic stroke.Extracranial carotid plaques with HRP features were more common in Caucasians.Intracranial plaques were more common in Chinese subjects,but no significant difference between the two cohorts in intracranial HRP prevalence was found.Larger studies using vessel wall imaging to investigate racial differences in cerebrovascular disease may inform underlying mechanisms of HRP development and may ultimately help guide appropriate therapy. | Hiroko Watase Mi Shen Binbin Sui Peiyi Gao Dong Zhang Jie Sun Niranjan Balu Daniel S Hippe Gail P Jarvik Xihai Zhao Rui Li Shuo Chen Chun Yuan Thomas S Hatsukami | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 2 | Burden of celiac disease in the Mediterranean area显示文摘AIM: To estimate the burden of undiagnosed celiac disease (CD) in the Mediterranean area in terms of morbidity, mortality and health cost. METHODS: For statistics regarding the population of each country in the Mediterranean area, we accessed authoritative international sources (World Bank, World Health Organization and United Nations). The prevalence of CD was obtained for most countries from published reports. An overall prevalence rate of 1% cases/total population was finally estimated to represent the frequency of the disease in the area, since none of the available conf idence intervals of the reported rates significantly excluded this rate. The distribution of symptoms and complications was obtained from reliable reports in the same cohort. A standardized mortality rate of 1.8 was obtained from recent reports. Crude health cost was estimated for the years between symptoms and diagnosis for adults and children, and was standardized for purchasing power parity to account for the different economic prof iles amongst Mediterranean countries. RESULTS: In the next 10 years, the Mediterranean area will have about half a billion inhabitants, of which 120 million will be children. The projected number of CD diagnoses in 2020 is 5 million cases (1 million celiac children), with a relative increase of 11% compared to 2010. Based on the 2010 rate, there will be about 550 000 symptomatic adults and about 240 000 sick children: 85% of the symptomatic patients will suffer from gastrointestinal complaints, 40% are likely to have anemia, 30% will likely have osteopenia, 20% of children will have short stature, and 10% will have abnormal liver enzymes. The estimated standardized medical costs for symptomatic celiac patients during the delay between symptom onset and diagnosis (mean 6 years for adults, 2 years for children) will be about €4 billion (€387 million for children) over the next 10 years. A delay in diagnosis is expected to increase mortality: about 600 000 celiac patients will die in the next 10 years, with an excess of 44.4% vs age-and sexmatched controls. CONCLUSION: In the near future, the burden of CD will increase tremendously. Few Mediterranean countries are able to face this expanding epidemic alone. | Luigi Greco Laura Timpone Abdelhak Abkari Mona Abu-Zekry Thomas Attard Faouzi Bouguerrà Paskal Cullufi Aydan Kansu Dusanka Micetic-Turk Zrinjka Miak Eleftheria Roma Raanan Shamir Selma Terzic | 2011 | World Journal of Gastroenterology2011，17，45： | 2 |
| 3 | PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees显示文摘 | Mi H Muruganujan A Thomas PD | 2013 | Nucleic Acids Res2013，41，： | 1 |
| 4 | Apoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin 显示文摘 | Mi Y Thomas SD Xu X | 2003 | J Biol Chem2003，278，10： | 1 |
| 5 | Apoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin显示文摘 | Mi Y Thomas SD Xu X | 2003 | J Biol Chem2003，278，10： | 1 |
| 6 | Demonstration of three major species of pseudorabies virus glycoprotein and identification of a disulfide-linked glycoprotein complex显示文摘 | Noé mi Lukàcs Heinz-Jürgen Thiel Thomas C Mettenleiter | 1985 | J Virol1985，53，1： | 1 |
| 7 | Comparison of echocardiographic markers of right ventricular function in deter-mining prognosis in chronic pulmonary disease 显示文摘 | Burgess MI Mogulkoc N Bright - Thomas RJ | 2002 | J Am Soc Echocardiogr2002，15，6： | 1 |
| 8 | Mapping of the structural gene of pseudorabies virus glycoprotein A and identification of two non-glycosylated precursor polypeptides 显示文摘 | Thomas C Mettenleiter Noèmi Lukàcs Hanns-Joachim Rziha | 1985 | J Virol1985，53，1： | 1 |
| 9 | Mixed Carbonate-Siliciclastic Deposits in a Channel Complex in the Northern South China Sea显示文摘New high-resolution 3D seismic data image a submarine channel complex in the northern slope of the South China Sea.The channel complex stretches hundreds of kilometers across the slope and flows into the deepsea from the siliciclastic shelf margin,linking neritic environment to the pelagic plain.The evolution of the channel complex developed two sedimentary stages,stage I(19.1–18.5 Ma)and stage II(18.5–17.5 Ma),separated by erosional surfaces.In the first stage,the complex was filled with pure siliciclastic sediments,forming thick-massive sandstone intercalated by thin layers of mudstone.During the stage II,the channel complex was deposited five carbonate-siliciclastic cycles.The unexpected channel-fill carbonate deposits present allochthonous characteristics,suggesting the siliciclastic channel was surprisingly used to transport carbonate sediment from the adjacent neritic carbonate platform.By analyzing the periodical carbonate sedimentary process in the siliciclastic channel complex,we infer that it was related to the in situ carbonate production of the neritic carbonate platform and was most likely to be controlled by the relative sea-level changes.Unlike line-source carbonate slope aprons or small-sized carbonate channels,the large-sized siliciclastic channel complex links directly neritic carbonate platform to deepwater basin and can transport large volumes of neritic carbonates to the pelagic environment in a short period.The new findings help to estimate the contributions of neritic siliciclastic shelf and carbonate platform to deepwater slope more accurately.This study suggests that channel systems are more complex than expected and have significant implications on the conceptual models describing the deepwater sedimentary theory. | Benjun Ma Shiguo Wu Lijun Mi Thomas Lüdmann Jinwei Gao Wei Gao | 2018 | Journal of Earth Science2018，29，3： | 1 |
| 10 | Enantioselective synthesis of α-sulfenylated ketones and aldehydes via α-thiolation of melated SAMP/RAMP hydrazones显示文摘 | Dieter Enders Thomas Schafer Wolfgang Mies | 1998 | Tetrahedron1998，54，10： | 1 |
| 11 | Pulmonary epithelial cells are a source of IL-8 in the response to Mycobacterium tuberculosis:essential role of IL-1 from infected monocytes in a NF-κB-dependent network显示文摘 | Wickremasinghe MI Thomas LH Friedland JS | 1999 | J Immunol1999，163，： | 1 |
| 12 | Apoptosis in leukemia cells is accom panied by al terations in the levels and localization of nucleolin显示文摘 | Mi Y Thomas SD Xu X | 2003 | J Biol Chem2003，278，10： | 1 |
| 13 | Preoperative prostate needle biopsy p27/kip1 correlates with subwsequent radical prostatectomy p27/kip1,Gleason grade and pathological stage显示文摘 | Schrage MI Rosenfelt L | 2000 | J Urol2000，164，6： | 1 |
| 14 | SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine显示文摘 | van Dy ck CH Rosen MI Thomas HM | 1994 | Psychiatry Res1994，55，4： | 1 |
| 15 | Some Results on Burn - In显示文摘 | Henry W Block Jie Mi Thomas H Savits | 1994 | Statistica Sinica1994，4，： | 1 |
| 16 | Molecular adsorbent recirculating system dialysis in patients with acute liver failure who are assessed for liver transplantation显示文摘 | Christophe Camus Sylvain Lavoué Arnaud Gacouin Yves Tulzo Richard Lorho Karim Boudjéma Christian Jacquelinet Rémi Thomas | 2006 | Intensive Care Medicine2006，，11： | 1 |
| 17 | Assessing the validity of the quality of life Enjoyment and Satisfaction Questionnaire-short Form in Adults with ADHD显示文摘 | Eric MI StephenV Thomas S | 2008 | J Attent Disord2008，11，： | 1 |
| 18 | Apoptosis in leukemia cells is acompanied by alterations in the levels and localization of nucleolin显示文摘 | Mi Y Thomas SD Xu X et a1 | 2003 | J Biol Chem2003，278，10： | 1 |
| 19 | Consumers' responses to negative word-of-mouth communication: An attribution theo- ry perspective显示文摘 | Laczniak Russell N DeCarlo Thomas E Ramaswa- mi Sridhar N | 2001 | Journal of Consumer Psychology2001，，1： | 1 |
| 20 | Lifestyle interventions for the treatment of non- alcoholic fatty liver disease in adults: a systematic review显示文摘 | THOMA C DAY CP TRENELL MI | 2012 | J Hepatol2012，56，1： | 1 |
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