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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | Re-discovering PDE3 inhibitors-new opportunities for a long neglected target显示文摘 | Thompson P E Manganiello V Degerman E | 2007 | Cur TopicsMed Chem2007，7，： | 1 |
| 3 | Margin Fit of CAD/CAM Produced Crowns 显示文摘 | Rekow E D Thompson V P Yang H S | 1991 | Dental Research1991，70，434： | 1 |
| 4 | The Computer-Aided Design of Modular Fixturing Systems 显示文摘 | Grippo P M Gandhi M V Thompson B S | 1987 | The Int J ofAdv ManufTechnology1987，2，2： | 1 |
| 5 | 显示文摘 | Rasmussen S C Thompson D W Singh V | 1996 | Inorg Chem1996，35，12： | 1 |
| 6 | Lipoxygenase-generated hydroperoxides account for the nonphysiological features of ethylene formation from 1-aminocyclopropane-1-carboxylic acid by microsomal membranes of carnations显示文摘 | Lynch D V Sridhara S Thompson J E | 1995 | Planta1995，164，： | 1 |
| 7 | Comeal thickness meas-urements with the Orbscan Topography System and ultrasonicpachymetry 显示文摘 | Yaylali V Kaufman SC Thompson HW | 1997 | J Cataract Refract Surg1997，23，9： | 1 |
| 8 | Is Z- disk degradation responsible for postmortem tenderiza- tion显示文摘 | Taylor R G Geesink G H Thompson V F | 1995 | Journal of Animal Science1995，73，4： | 1 |
| 9 | A technique for the mass propagation of the DD-136 nematode 显示文摘 | Dutky S R Thompson J V Cantwell G E | 1964 | Journal of In- vertebrate Pathology1964，6，： | 1 |
| 10 | Computational fluid dynamic analysis and design optimization of jet pumps 显示文摘 | Fan J Eves J Thompson H M Toropov V V Kapur N Copley D Mincher A | 2011 | Computers Fluids2011，46，： | 1 |
| 11 | Transition to chaos in acoustically driven flow(acoustic stream)显示文摘 | Thompson C Mulpur A Mehta V | 1991 | The Journal of the Acoustical Society of America1991，90，： | 1 |
| 12 | Evaluation of differences in percentage of international normalized ratios in range between pharmacist-led and physician-led anticoagulation management services显示文摘 | Gupta V Kogut SJ Thompson S | 2015 | J Pharm Pract2015，28，3： | 1 |
| 13 | Optical deconstruction of parkinsonian neural circuitry 显示文摘 | Gradinaru V Mogri M Thompson KR | 2009 | Science2009，324，5925： | 1 |
| 14 | Differential screening and suppression snbtractive hybridazation identified genes differentially expressed in an estrogen receptor-positive breast carcinoma cell line 显示文摘 | Kuang W W Thompson D A Hoeh R V Weigel R J | 1998 | Nucleic Acids Res1998，26，： | 1 |
| 15 | Folding dynamics and mechanism of beta-hairpin formation显示文摘 | Munoz V Thompson P A Hofrichter J | 1997 | Nature1997，390，： | 1 |
| 16 | Parameters of superpopulation and survey population:Their relationship and estimation显示文摘 | Godmanbe V P Thompson M E | 1986 | Int Statist Rev1986，54，： | 1 |
| 17 | The Wnt pool of glycogen synthase kinase 3beta is critical for trophic-depriva- tion-induced neuronal death 显示文摘 | Hongisto V Vainio JC Thompson R | 2008 | Mol Cell Biol2008，28，5： | 1 |
| 18 | Cost-effectiveness and efficiency of shockwave lithotripsy vs flexible ureteroscopic holrnium:yttrium-alumiu- lure-garnet laser lithotripsy in the treatment of lower pole renal calculi 显示文摘 | Koo V Young M Thompson T | 2011 | B J U Int2011，108，： | 1 |
| 19 | Characterization of Anthocyanins and Anthocyanidins in Purple-Fleshed Sweetpotatoes by HPLC-DAD/ESI-MS/MS显示文摘 | Truong V Deighton N Thompson R T | 2010 | Journal of Agricultural and Food Chemistry2010，58，2： | 1 |
| 20 | Dependence of the electromigration flux on the crystallographic orientations of different grains in polycrystalline copper interconnects显示文摘 | CHOI Zung-sun MONIG REINER THOMPSON C V | 2007 | Appl Phys Lett2007，90，24： | 1 |
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