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| 1 | VSG-based Adaptive Droop Control for Frequency and Active Power Regulation in the MTDC System显示文摘In this paper,a VSG(virtual synchronous generator)-based method with adaptive active power and DC voltage droop is proposed for the control of VSC stations in the multi-terminal DC(MTDC)system.This control strategy can improve the inertial level of the AC networks and attenuate the rate of change of frequency when a disturbance occurs.In addition,the droop control of the active power and DC voltage is implemented to make the AC networks share the unbalanced power in the MTDC.The droop coefficients are adaptively adjusted depending on the frequency margin of every AC network,which makes the allocation of unbalanced power among AC networks more reasonable from the frequency variation perspective.The control strategy is evaluated in the scenarios of sudden load change and wind turbine tripping,and the results are presented to demonstrate its effectiveness. | Ren Wang Laijun Chen Tianwen Zheng Shengwei Mei | 2017 | CSEE Journal of Power and Energy Systems2017，3，3： | 13 |
| 2 | Lumbar pedicle cortical bone trajectory screw显示文摘 | Song Tengfei Wellington K Hsu Ye Tianwen | 2014 | Chinese Medical Journal2014，，21： | 11 |
| 3 | Living concrete with self-healing function on cracks attributed to inclusion of microorganisms: Theory, technology and engineering applications——A review显示文摘Concrete is the most widely used composite material in civil engineering.Microbial induced calcium carbonate precipitation(MICP)is a green and environmental friendly technology,which has received extensive attention in repair of concrete cracks.This paper introduces the research progress in Southeast University research in past 16 years.In the early stage,MICP technology of urea hydrolyzed by Bacillus pasteurii was mainly investigated to repair the surface cracks and to fill large-size cracks with grouting.However,aiming at the hidden cracks that were difficult for human intervention,a new mineralization route of Bacillus mucilaginosus was proposed,which could repair faster than Bacillus alcalophilus,and the problem of ammonia emission in the repair process of Bacillus pasteurii was also solved.In addition,in order to improve the protection of bacteria and the self-healing efficiency of the later age cracks,the methods of fiber immobilization,carrier uniformly immobilization and core-shell structural immobilization had been compared and studied.The results showed that core-shell structural immobilization had good protection ability and strong designability.What’s more,the paper also summarized the characteristics of spore germination,cell activity,nucleation and biological calcium carbonate in crack zone,and introduced the application experience of microbial self-healing concrete in water conservancy projects and subway stations. | QIAN ChunXiang ZHENG TianWen RUI YaFeng | 2021 | Science China(Technological Sciences)2021，64，10： | 7 |
| 4 | Kallistatin,a new and reliable biomarker for the diagnosis of liver cirrhosis显示文摘Kallistatin,which protects organs and cells against inflammation,fibrosis and oxidative stress,is mainly synthesized and secreted in liver.However,its relationship to human liver disease remains unclear.The purpose of this study was to explore the relationship between serum kallistatin and clinical evidence of both cirrhosis and hepatocellular carcinoma(HCC),and to determine if serum kallistatin levels could be used as a diagnostic indicator of hepatic health status,especially human liver cirrhosis(LC).Our cohort consisted of 115 patients with clinically proven liver fibrosis(LF),LC,or HCC by liver biopsies,and 31 healthy controls(CON).Serum kallistatin levels were quantified by ELISA.Results of the present study demonstrated that irrespective of the underlying etiology,serum kallistatin levels were significantly lower in the LF/LC group when compared with the CON group.A decrease in serum kallistatin levels appeared to reflect the extent of cirrhosis,with the lowest levels associated with higher grades of cirrhosis.Patients with LC had a noticeable correlation between serum kallistatin levels and other serum biochemical indicators.The area under the curve(AUC) for LC,viral liver cirrhosis(VLC)and alcoholic liver cirrhosis(ALC) was 0.845,0.757 and 0.931,respectively.In conclusion,our findingsdemonstrated that kallistatin,a plasma protein produced by the liver,can be a useful and reliable diagnostic indicator of hepatic health status,especially for LC. | Zhiyun Cheng Yinghui Lv Suqiu Pang Ruyu Bai Mingxi Wang Shuyu Lin Tianwen Xu Duncan Spalding Nagy Habib Ruian Xu | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 7 |
| 5 | Studies of biouptake and transformation of mercury by a typical unicellular diatom Phaeodactylum tricornutum显示文摘Mercury(Hg) is a toxic heavy metal with its biogeochemical cycling in the ocean depending on the type and behavior of the oceanic microalgae.The present work aimed to evaluate bioaccumulation and transformation of Hg by Phaeodactylum tricornutum,a typical unicellular diatom,when exposed to the extremely high level of Hg in order to understand the possible mechanisms of acute stress response.P.tricornutum can accumulate Hg(its bioaccumulation factor is at 104 level),and the 96 h EC 50 was estimated to be 145μg L-1.The amounts of surface-bound Hg being about 1.2 to 4.8 times higher than those of intracellular Hg under exposure to HgCl 2(from 20 to 120μg L-1 concentrations) suggested that the cell wall of P.tricornutum is an important 'fence' towards Hg.After entering the P.tricornutum cell,Hg underwent transformation in its chemical form via interactions with high molecular weight sulfur-containing proteins(accounting for 68% of the intracellular Hg),and glutathione as well as the induced phytochelatins(PCs)(24% Hg) which alleviated the toxicity of HgCl2.In addition,the existence of organic ligands greatly influenced the uptake and transformation behavior of P.tricornutum towards HgCl2,especially in the case of cysteine(Cys),which increased the uptake of Hg,but alleviated the toxicity of Hg towards P.tricornutum due to the fact that Cys is an important precursor for the synthesis of PCs inside the cell.The uptake process of Hg by P.tricornutum was in agreement with the Freundlich isotherm,suggesting a typical heterogeneous sorption process.More importantly,we observed the conversion of HgCl2 into methylmercury inside the P.tricornutum cells and its release into the culture solution using HPLC/CVG-AFS and GC-MS,although the mechanism needs to be further investigated. | DENG GuiFu ZHANG TianWen YANG LiMin WANG QiuQuan | 2013 | Chinese Science Bulletin2013，58，2： | 7 |
| 6 | 3D stability analysis method of concave slope based on the Bishop method显示文摘In order to study the stability control mechanism of a concave slope with circular landslide, and remove the influence of differences in shape on slope stability, the limit analysis method of a simplified Bishop method was employed. The sliding body was divided into strips in a three-dimensional model, and the lateral earth pressure was put into mechanical analysis and the three-dimensional stability analysis methods applicable for circular sliding in concave slope were deduced. Based on geometric structure and the geological parameters of a concave slope, the influence rule of curvature radius and the top and bottom arch height on the concave slope stability were analyzed. The results show that the stability coefficient decreases after growth, first in the transition stage of slope shape from flat to concave, and it has been confirmed that there is a best size to make the slope stability factor reach a maximum. By contrast with average slope, the stability of a concave slope features a smaller range of ascension with slope height increase, which indicates that the enhancing effect of a concave slope is apparent only with lower slope heights. | Zhang Tianwen Cai Qingxiang Han Liu Shu Jisen Zhou Wei | 2017 | International Journal of Mining Science and Technology2017，27，2： | 6 |
| 7 | Flexible unbalanced control with peak current limitation for virtual synchronous generator under voltage sags显示文摘Virtual synchronous generator(VSG)is gridfriendly for integrating distributed generations(DGs)since it can emulate the operation mechanism of traditional synchronous generator(SG).However,the traditional VSG control strategy,which is mainly suitable for balanced voltage conditions,may lead to power oscillations,current unbalance and even overcurrent under unbalanced voltage sags.To overcome this difficulty,a flexible unbalanced control with peak current limitation for VSG under unbalanced operating conditions is proposed.Based on the basic VSG control algorithm,the control strategy integrates two novel control modules,which are current reference generator(CRG)and power reference generator(PRG).The proposed control strategy can flexibly meet different operation demands,which includes current balancing,constant active or reactive power.And the injected currents are kept within safety values for a better utilization of the VSG power capacity.Furthermore,the experimental platform is built.Experimental results demonstrate the validness and effectiveness of the proposed control strategy. | Tianwen ZHENG Laijun CHEN Yan GUO Shengwei MEI | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，1： | 6 |
| 8 | Long-term,multidomain analyses to identify the breed and allelic effects in MSTN-edited pigs to overcome lameness and sustainably improve nutritional meat production显示文摘Beef and mutton production has been aided by breeding to integrate allelic diversity for myostatin(MSTN),but a lack of diversity in the MSTN germplasm has limited similar advances in pig farming.Moreover,insurmountable challenges with congenital lameness and a dearth of data about the impacts of feed conversion,reproduction,and meat quality in MSTN-edited pigs have also currently blocked progress.Here,in a largest-to-date evaluation of multiple MSTN-edited pig populations,we demonstrated a practical alternative edit-site-based solution that overcomes the major production obstacle of hindlimb weakness.We also provide long-term and multidomain datasets for multiple breeds that illustrate how MSTN-editing can sustainably increase the yields of breed-specific lean meat and the levels of desirable lipids without deleteriously affecting feed-conversion rates or litter size.Apart from establishing a new benchmark for the data scale and quality of genome-edited animal production,our study specifically illustrates how gene-editing site selection profoundly impacts the phenotypic outcomes in diverse genetic back-grounds. | Ziyao Fan Zhiguo Liu Kui Xu Tianwen Wu Jinxue Ruan Xinmin Zheng Shideng Bao Yulian Mu Tad Sonstegard Kui Li | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 9 | An applied research on remote sensing classification in the Loess Plateau显示文摘Due to complex terrain of the Loess Plateau, the classification accuracy is unsatisfactory when a single supervised classification is used in the remote sensing investigation of the sloping field. Taking the loess hill and gully area of northern Shaanxi Province as a test area, a research was conducted to extract sloping field and other land use categories by applying an integrated classification. Based on an integration of supervised classification and unsupervised classification, sampling method is remarkably improved. The results show that the classification accuracy is satisfactory by the method and is of critical significance in obtaining up-to-date information of the sloping field, which should be helpful in the state key project of converting fiumland to forest and grassland on slope land in this area. This research sought to improve the appfication accuracy of image classification in complex terrain areas. | LIU Yongmei TANG Guoan LI Tianwen YANG Qinke | 2003 | Journal of Geographical Sciences2003，13，4： | 5 |
| 10 | Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir,Its Parent Nucleoside and β-D-N^(4)-hydroxycytidine显示文摘Porcine epidemic diarrhea(PED)caused by porcine epidemic diarrhea virus(PEDV)is widespread in the world.In recent years,the increased virulence of the virus due to viral variations,has caused great economic losses to the pig industry in many countries.It is always worthy to find effective therapeutic methods for PED.As an important class of antivirals,nucleoside drugs which target viral polymerases have been applied in treating human viral infections for half a century.Herein,we evaluated the anti-PEDV potential of three broad-spectrum antiviral nucleoside analogs,remdesivir(RDV),its parent nucleoside(RDV-N)andβ-D-N^(4)-hydroxycytidine(NHC).Among them,RDV-N was the most active agent in Vero E6 cells with EC_(50) of 0.31μmol/L,and more potent than RDV(EC_(50)=0.74μmol/L)and NHC(EC_(50)=1.17μmol/L).The activity of RDV-N was further confirmed using an indirect immuno-fluorescence assay.Moreover,RDV-N exhibited a good safety profile in cells and in mice.The high sequence similarity of the polymerase functional domains of PEDV with other five porcine coronaviruses indicated a broader antiviral spectrum for the three compounds.Generally,RDV-N is a promising broad-spectrum antiviral nucleoside,and it would be worthy to make some structural modifications to increse its oral bioavailability. | Yuanchao Xie Xiaozhen Guo Tianwen Hu Daibao Wei Xiuli Ma Jiaqiang Wu Bing Huang Jingshan Shen | 2021 | Virologica Sinica2021，36，5： | 3 |
| 11 | Exposure to blast shock waves via the ear canal induces deficits in vestibular afferent function in rats显示文摘The ears are air-filled structures that are directly impacted during blast exposure.In addition to hearing loss and tinnitus,blast victims often complain of vertigo,dizziness and unsteady posture,suggesting that blast exposure induces damage to the vestibular end organs in the inner ear.However,the underlying mechanisms remain to be elucidated.In this report,single vestibular afferent activity and the vestibuloocular reflex(VOR)were investigated before and after exposure to blast shock waves(~20 PSI)delivered into the left external ear canals of anesthetized rats.Single vestibular afferent activity was recorded from the superior branch of the left vestibular nerves of the blast-treated and control rats one day after blast exposure.Blast exposure reduced the spontaneous discharge rates of the otolith and canal afferents.Blast exposure also reduced the sensitivity of irregular canal afferents to sinusoidal head rotation at 0.5e2Hz.Blast exposure,however,resulted in few changes in the VOR responses to sinusoidal head rotation and translation.To the best of our knowledge,this is the first study that reports blast exposure-induced damage to vestibular afferents in an animal model.These results provide insights that may be helpful in developing biomarkers for early diagnosis of blast-induced vestibular deficits in military and civilian populations. | Yue Yu Jun Huang Xuehui Tang Jerome Allison David Sandlin Dalian Ding Yi Pang Chunming Zhang Tianwen Chen Nathan Yin Lan Chen William Mustain Wu Zhou Hong Zhu | 2020 | Journal of Otology2020，15，3： | 3 |
| 12 | Neurological function following intra-neural injection of fluorescent neuronal tracers in rats显示文摘Fluorescent neuronal tracers should not be toxic to the nervous system when used in long-term labeling.Previous studies have addressed tracer toxicity,but whether tracers injected into an intact nerve result in functional impairment remains to be elucidated.In the present study,we examined the functions of motor,sensory and autonomic nerves following the application of 5% Fluoro-Gold,4% True Blue and 10% Fluoro-Ruby (5μL) to rat tibial nerves via pressure injection.A set of evaluation methods including walking track analysis,plantar test and laser Doppler perfusion imaging was used to determine the action of the fluorescent neuronal tracers.Additionally,nerve pathology and ratio of muscle wet weight were also observed.Results showed that injection of Fluoro-Gold significantly resulted in loss of motor nerve function,lower plantar sensibility,increasing blood flow volume and higher neurogenic vasodilatation.Myelinated nerve fiber degeneration,unclear boundaries in nerve fibers and high retrograde labeling efficacy were observed in the Fluoro-Gold group.The True Blue group also showed obvious neurogenic vasodilatation,but less severe loss of motor function and degeneration,and fewer labeled motor neurons were found compared with the Fluoro-Gold group.No anomalies of motor and sensory nerve function and no myelinated nerve fiber degeneration were observed in the Fluoro-Ruby group.Experimental findings indicate that Fluoro-Gold tracing could lead to significant functional impairment of motor,sensory and autonomic nerves,while functional impairment was less severe following True Blue tracing.Fluoro-Ruby injection appears to have no effect on neurological function. | Wen Hu Dan Liu Yanping Zhang Zhongyi Shen Tianwen Gu Xiaosong Gu Jianhui Gu | 2013 | Neural Regeneration Research2013，8，14： | 3 |
| 13 | Probe on Network-based Collaborative Maintenance Model for After-sales Equipment显示文摘In order to make equipment run safely,economically and continuously,some new maintenance models were put forward to improve the equipment after-sale maintenance service,such as E-maintenance,third-party maintenance,etc.To certain extent,the models solved the problem of the distance between the manufacturer and customer and the dispersion of the maintenance technologies,however,those resources are still widely distributed and do not collaborate efficiently.In this paper,a network-based collaborative maintenance service model was proposed for after-sales equipment to solve the problem of maintenance resources integration.Concretely,equipment designers,maintainers,spare parts suppliers and maintenance experts were grouped together to establish dynamic alliance.The leader of the alliance is the manufacturer under guaranty period or equipment user exceeding the guaranty period.The process of maintenance service was divided into three stages which are fault diagnosis,maintenance decision and maintenance implementation.The sub-alliances were established to carry out maintenance work at each stage.In addition,the business process of network-based collaborative maintenance was analyzed and collaborative business system for equipment's after-sales collaborative maintenance service was designed.In the end,an informational economics model of network-based collaborative maintenance was established to demonstrate the effectiveness of this maintenance model. | CHEN Xiaohui SHENG Tianwen YI Shuping | 2009 | Chinese Journal of Mechanical Engineering2009，22，5： | 2 |
| 14 | Phylogenetic relationship and morphological evolution in the subfamily Limenitidinae(Lepidoptera:Nymphalidae)显示文摘mitochondrial 细胞色素氧子单元我(COI ) 基因和原子延伸因子 1 α(EF-1 α) 基因从 Nymphalidae 的 29 种类被定序(Nymphalidae,鳞翅目) 。种系发生的树基于从 29 种类决定的序列和在 GenBank 扔用的另外的 36 种类的序列被构造加入邻居(NJ ) ,最大的可能性(ML ) 和有 Libythea celtis (Libytheinae ) 的贝叶斯的方法作为外集团。我们的种系发生的树显示了四主要 clades。Clade A 包括三个亚科:Apaturinae, Nymphalinae,和 Limenitidinae,排除部落 Limenitidini;Clade B 包括亚科 Heliconiinae 和部落 Limenitidini;Clade C 包括 Satyrinae, Calinaginae, Charaxinae 和 Morphinae;并且 Clade D 包括亚科 Danainae。我们的学习建议部落 Pseudergolini, Biblidini, Limenitidini 和 Cyrestidini 应该被看作亚科并且在亚科 Pseudergolinae 以内证实了种间的关系,也就是 Amnosia +(Pseudergolis +(Stibochiona + Dichorragia )) 。我们然后印射三个词法字符(从后部的翅膀的外部边缘的肛门角度,视觉器官,和过程的点) 到 ML 分析用联合顺序数据构造的种系发生的树上。把这些词法人物的进化模式基于这被识别,他们显示三个人物在家庭 Nymphalidae 反复演变。 | Min Zhang Yang Zhong Tianwen Cao Yupeng Geng Yuan Zhang Ke Jin Zhumei Ren Rui Zhang Yaping Guo Enbo Ma | 2008 | Progress in Natural Science:Materials International2008，18，11： | 2 |
| 15 | Magnetostratigraphic dating of the Hougou Paleolithic site in the Nihewan Basin,North China显示文摘The fluvio-lacustrine sedimentary sequences in the Nihewan Basin,northern China,are important for studying Quaternary land mammal evolution and Paleolithic settlements in the high-latitude temperate East Asia.Here we report new magnetostratigraphic results that constrain age of the Hougou Paleolithic site in this basin.Magnetite and hematite were identified as carriers of the characteristic remanent magnetizations,with the former being dominant.Magnetic polarity stratigraphy shows that the Hougou sequence recorded the very late Matuyama reverse chron and the Brunhes normal chron.The age of the Hougou Paleolithic site was estimated to be 395 ka based on an averaged rate of sediment accumulation.The combination of our magnetostratigraphy and previously published chronological data for early Paleolithic or human sites in the high-latitude northern China may document a persistent colonization of the hostile high-latitude areas of the eastern Old World during the middle-early Pleistocene. | ZUO TianWen CHENG HongJiang LIU Ping XIE Fei DENG ChengLong | 2011 | Science China Earth Sciences2011，54，11： | 2 |
| 16 | In vivo calcium imaging and Parkinson's disease显示文摘Brain function depends on patterns of synaptic input and neurocircuits,which are accompanied by transient changes in free intracellular calcium concentration(Resendez et al.,2015).A recent topic of interest has been the illumination of neuronal circuit activity by calcium imaging in vivo.As a new biological tool for recording behavioral signals in the animal brain,in vivo calcium imaging is performed to monitor neuronal activity based on intracellular calcium.In | Tianwen Huang Qinyong Ye | 2016 | Science China(Life Sciences)2016，59，12： | 2 |
| 17 | SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/b-catenin signaling显示文摘Secreted frizzled-related protein 5(SFRP5)plays a pivotal role in regulating the development of many tissues and organs,however,as an inhibitor of Wnt signaling,the role of SFRP5 in vitiligo remains unknown.Hence,we speculated that SFRP5 might be associated with melanogenesis in melanocytes by regulating Wnt signaling in vitiligo.In this study,we found that SFRP5 was overexpressed in the skin lesions of patients with vitiligo.Compared with that in normal epidermal melanocytes(PIG1),the expression of SFRP5 was increased in vitiligo melanocytes(PIG3V).To investigate the effect of SFRP5 on melanin synthesis,PIG1 cells were infected with recombinant SFRP5 adenovirus(AdSFRP5),and PIG3V cells were infected with recombinant siSFRP5 adenovirus(AdsiSFRP5).The results showed that SFRP5 overexpression inhibited melanin synthesis in PIG1 cells through downregulation of microphthalmia-associated transcription factor(MITF)and its target proteins via suppression of the Wnt/b-catenin signaling pathway.Accordingly,SFRP5 silencing increased melanin synthesis and activated the Wnt signaling pathway in PIG3V cells.Moreover,SFRP5 overexpression also downregulated the transcriptional activity of T cell factor/lymphoid enhancer factor(TCF/LEF)in PIG1 cells.Furthermore,this inhibitory effect of SFRP5 on melanin synthesis was reversed by treatment with the b-catenin agonist,SKL2001.The inhibitory action of SFRP5 in pigmentation was further confirmed in vivo using a nude mouse model.Hence,our results indicate that SFRP5 can inhibit melanogenesis in melanocytes.Additionally,our findings showed that SFRP5 plays a vital role in the development of vitiligo,and thus may serve as a potential therapeutic target for vitiligo. | Daopei Zou Yangmei Chen Lingzhao Zhang Xiaohui Yuan Yujie Zhang Adelina Inggawati Pham Thi Kieu Nguyet Tianwen Gao Jin Chen | 2021 | Genes & Diseases2021，8，5： | 2 |
| 18 | Unscented Kalman Filter for Visual Cure Tracking 显示文摘 | LI Peihua ZHANG Tianwen MA Bo | 2004 | Real-time Image and Vision Computing2004，22，2： | 1 |
| 19 | Screening and characterization of an aerobic nitrifying - denitrifying bacterium from activated sludge 显示文摘 | Qiu Xiaofan Wang Tianwen Zhong Xiaomin | 2012 | Biotechnology and Bioprocess Engineering2012，17，2： | 1 |
| 20 | Mutational spectrum of phenylketonuria in the Chinese Han population: a novel insight into the geographic distribution of the common mutations 显示文摘 | ZHU Tianwen QIN Shengying YE Jun | 2010 | Pediatric Research2010，67，3： | 1 |
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