|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure显示文摘AIM To evaluate the effect of norepinephrine on inflammatory cytokine expression in ex vivo human monocytes and monocytic THP-1 cells. METHODS For human monocyte studies, cells were isolated from 12 chronic heart failure(HF)(66 ± 12 years, New York Heart Association functional class Ⅲ-Ⅳ, left ventricular ejection fraction 22% ± 9%) and 14 healthy subjects(66 ± 12 years). Monocytes(1 × 106/mL) were incubated with lipopolysaccharide(LPS) 100 ng/m L, LPS + norepinephrine(NE) 10-6 mol/L or neither(control) for 4 h. Tumor necrosis factor-alpha(TNFα) and interleukin-10(IL-10) production were determined by ELISA. Relative contribution of α- and β-adrenergic receptor subtypes on immunomodulatory activity of NE was assessed in LPSstimulated THP-1 cells incubated with NE, the α-selective agonist phenylephrine(PE), and the β-selective agonist isoproterenol(IPN). NE-pretreated THP-1 cells were also co-incubated with the β-selective antagonist propranolol(PROP), α2-selective antagonist yohimbine(YOH) or the α1-selective antagonist prazosin(PRAZ). RESULTS Basal TNFα concentrations were higher in HF vs healthy subjects(6.3 ± 3.3 pg/mL vs 2.5 ± 2.6 pg/mL, P = 0.004). Norepinephrine's effect on TNFα production was reduced in HF(-41% ± 17% HF vs -57% ± 9% healthy, P = 0.01), and proportionately with NYHA FC. Increases in IL-10 production by NE was also attenuated in HF(16% ± 18% HF vs 38% ± 23% healthy, P = 0.012). In THP-1 cells, NE and IPN, but not PE, induced a dosedependent suppression of TNFα. Co-incubation with NE and antagonists revealed a dose-dependent inhibition of the NE suppression of TNFα by PROP, but not by YOH or PRAZ. Dose-dependent increases in IL-10 production were seen with NE and IPN, but not with PE. This effect was also antagonized by PROP but not by YOH or PRAZ. Pretreatment of cells with IPN attenuated the effects of NE and IPN, but did not induce a response to PE.CONCLUSION NE regulation of monocyte inflammatory cytokine production may be reduced in moderate-severe HF, and may be mediated through β-adrenergic receptors. | Tien MH Ng Myron L Toews | 2016 | World Journal of Cardiology2016，8，10： | 4 |
| 2 | Natural convection in porous media bounded by concentric spheres and horizontal cylinders显示文摘 | Burns P J Tien C L | 1979 | Int J Heat Mass transfer1979，，22： | 2 |
| 3 | Radiation characteristics of honeycomb solar collectors 显示文摘 | Tien C L Yuen W W | 1975 | International Journal of Heat and Mass Transfer1975，18，12： | 1 |
| 4 | Self - assembled bilayer lipid membranes: from mimicking biomembranesto practical applications 显示文摘 | Angelica L Ottova H Ti Tien | 1997 | Bioelectrochemistry and Bioenergetic1997，42，： | 1 |
| 5 | Ultrashort-pluse laser heating of silicon to reduce microstructure adhesion显示文摘 | Fushinobu K Phinney L M Tien N C | 1996 | Int J Heat Mass Transfer1996，39，15： | 1 |
| 6 | Does the involvement of private equity investments matter to fiem performance and internationliazation 显示文摘 | Tien C L Ho Y Chiu H J | 2008 | Journal of American Academy of Business2008，13，2： | 1 |
| 7 | The lipid bilayer concept and its experimental realization: from soap bubbles, kitchen sink, to bilayer lipid membranes 显示文摘 | H Ti Tien Angelica L Ottova | 2001 | Journal of Membrance Science2001，4886，： | 1 |
| 8 | Analysis of condensation in porous insulation显示文摘 | Ogniewicz Y Tien C L | 1981 | J Heat Mass Transfer1981，24，： | 1 |
| 9 | Fractal characterization and simuiation of rough surfaces显示文摘 | MAJUMDAR A TIEN C L | 1990 | Wear1990，136，2： | 1 |
| 10 | Fractal characterization and simulation of rough surfaces 显示文摘 | Majumdar A Tien C L | 1990 | Wear1990，136，2： | 1 |
| 11 | Optical constants of liq uid hydrocarbon fuels显示文摘 | Tuntomo A Tien C L Park S H | 1992 | Combustion Science and Tech- nology1992，84，1： | 1 |
| 12 | Ginsenosides Rgl and Rbl enhance glutamate release through activation of protein kinase A in rat cerebrocortical nerve terminals (synaptosomes) 显示文摘 | CHANG Y HUANG W J TIEN L T | 2008 | Eur J Pharmacol2008，578，1： | 1 |
| 13 | Altered immunity accompanies disease progresssion in a mouse model of prostate dysplasia显示文摘 | Tien A H Xu L Helgason C D | 2005 | Cancer Res2005，65，7： | 1 |
| 14 | Short-pulse laser-heating on metals显示文摘 | Qiu T Q Tien C L | 1992 | International Journal of Heat and Mass Transfer1992，35，3： | 1 |
| 15 | Fractal Characterization and Simulation of Rough Surfaces 显示文摘 | Majumdar A Tien C L | 1990 | Wear1990，136，： | 1 |
| 16 | Optical constants of liquid hydrocarbon fuels 显示文摘 | A Tuntomo C L Tien S H Park | 1992 | Combust Sci Technol1992，84，16： | 1 |
| 17 | Fractal Characterization and Simulation of Rough Surfaces 显示文摘 | Majumdar A Tien C L | 1990 | Wear1990，，136： | 1 |
| 18 | Risk of varices bleeding after spleen-preserving distal panereatectomy with excision of splenic artery and vein 显示文摘 | TIEN Y W LIU K L HU R H | 2010 | Ann Surg Oncol2010，17，8： | 1 |
| 19 | ZnO nanowire growth and devices 显示文摘 | Heo Y W Norton D P Tien L C | 2004 | Materials Science Engineering2004，47，： | 1 |
| 20 | Non-Darcy convection in cylindrical packed beds显示文摘 | Hunt M L Tien C L | 1996 | Journal of Heat Transfer1996，39，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员