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| 1 | Speckle tracking echocardiography:A new approach to myocardial function显示文摘Echocardiography is the most common diagnostic method for assessing cardiac function but some limitations affect this technique.Until now,visual assessment of wall motion and thickening has allowed only a subjective evaluation of myocardial function and requires long-term training.Recently,new echocardiographic techniques have been introduced to evaluate myocardial mechanics.Tissue Doppler imaging(TDI)technique is limited by angle-dependency such that only deformation along the ultrasound beam can be derived from velocities,while myocardium deforms simultaneously in three dimensions.Speckle tracking echocardiography (STE)is a more recent technique that provides a global approach to left ventricular myocardial mechanics,giving information about the three spatial dimensions of cardiac deformation.In this editorial,we describe the physical and pathophysiological concepts of STE,discussing the differences compared to TDI and underlining the pitfalls of this new technique. | Simona Sitia Livio Tomasoni Maurizio Turiel | 2010 | World Journal of Cardiology2010，2，1： | 19 |
| 2 | Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10)显示文摘Tolerogenic dendritic cells(DCs)are key players in maintaining immunological homeostasis,dampening immune responses,and promoting tolerance.DC-10,a tolerogenic population of human IL-10-producing DCs characterized by the expression of HLA-G and ILT4,play a pivotal role in promoting tolerance via T regulatory type 1(Tr1)cells.Thus far,the absence of markers that uniquely identify DC-10 has limited in vivo studies.By in vitro gene expression profiling of differentiated human DCs,we identified CD141 and CD163 as surface markers for DC-10.The coexpression of CD141 and CD163 in combination with CD14 and CD16 enables the ex vivo isolation of DC-10 from the peripheral blood.CD14+CD16+CD141+CD163+cells isolated from the peripheral blood of healthy subjects(ex vivo DC-10)produced spontaneously and upon activation of IL-10 and limited levels of IL-12.Moreover,in vitro stimulation of allogeneic naive CD4+T cells with ex vivo DC-10 induced the differentiation of alloantigen-specific CD49b+LAG-3+Tr1 cells.Finally,ex vivo DC-10 and in vitro generated DC-10 exhibited a similar transcriptional profile,which are characterized by an anti-inflammatory and pro-tolerogenic signature.These results provide new insights into the phenotype and molecular signature of DC-10 and highlight the tolerogenic properties of circulating DC-10.These findings open the opportunity to track DC-10 in vivo and to define their role in physiological and pathological settings. | Michela Comi Daniele Avancini Francesca Santoni de Sio Matteo Villa Molly Javier Uyeda Matteo Floris Daniela Tomasoni Alessandro Bulfone Maria Grazia Roncarolo Silvia Gregori | 2020 | Cellular & Molecular Immunology2020，17，1： | 4 |
| 3 | Transcriptional regulation of nephrin gene by peroxisome proliferator-activated receptor-γ agonist:molecular mechanism of the antiproteinuric effect of pioglitazone显示文摘 | Zoja C Tomasoni S | 2006 | J Am Soc Nephrol2006，17，6： | 1 |
| 4 | Selective impairment of gene expression and assembly of nephrin in human diabetic nephropathy 显示文摘 | Benigni A Gagliardini E Tomasoni S | 2004 | Kidney Int2004，65，6： | 1 |
| 5 | From endothelial dysfunction to atherosclerosis 显示文摘 | Sitia S Tomasoni L Atzeni F | 2010 | Autoimmun Rev2010，9，： | 1 |
| 6 | Cell cycle effects of gemcitabine显示文摘 | Cappella P Tomasoni D Faretta M | 2001 | Int J Cancer2001，93，3： | 1 |
| 7 | Upregulation of renal and systemic cyclooxygenase-2 in patients with active lupus nephritis显示文摘 | Tomasoni S Noris M Zappella S | 1998 | J Am Soc Nephrol1998，9，7： | 1 |
| 8 | Efficient OFDM channel estimation via an information criterion 显示文摘 | Tomasoni A Gatti D Bellini S | 2013 | IEEE Transactions on Wireless Communications2013，12，3： | 1 |
| 9 | Selective impairment of gene expression and assembly of nephrin in human diabetic nephropathy显示文摘 | Benigni A Gagliardini E Tomasoni S | 2004 | Kidney Int2004，65，6： | 1 |
| 10 | Selective impairment of gene expression and assembly of nephrin in human diabetic nephropathy 显示文摘 | Benigni A Gagliardini E Tomasoni S | 2004 | Kidney Int2004，65，6： | 1 |
| 11 | Targeted down regulation of extracellular nephrin in human IgA nephropathy显示文摘 | Gagliardini E Benigni A Tomasoni S | 2003 | Am J Nephrol2003，23，4： | 1 |
| 12 | Transcriptional regulation of nephrin gene by peroxisome proliferator-activated receptorgamma agonist : molecular mechanism of the antiproteinuric effect of pioglitazone显示文摘 | Benigni A Zoja C Tomasoni S | 2006 | J Am Soc Nephrol2006，17，6： | 1 |
| 13 | Selective impairment of gene expression and assembly of nephrin in human diabetic nephropathy显示文摘 | Benigni A Gagliardini E Tomasoni S | 2004 | Kidney Int2004，65，： | 1 |
| 14 | Selective impairment of gene expression and assembly of nephrin in human diabetic nephropathy显示文摘 | Benigni A Gagliardini E Tomasoni S | 2004 | Kidney Int2004，65，6： | 1 |
| 15 | Epidemiologic surveillance of multidrug resistant Pseudomonas aeruginosa in Mantova Hospital (Italy)显示文摘 | Tomasoni D Gattuso G Chiarelli C | 2006 | Infez Med2006，14，2： | 1 |
| 16 | Selective impairment of gene expression and assembly of nephrin in human diabetic nephropathy显示文摘 | Benigni A Gagliardini E Tomasoni S | 2004 | Kidney Int2004，65，6： | 1 |
| 17 | Favorable effect of cotransfection with TGF-beta and CTLA41g of the donor kidney on allograft survival显示文摘 | Tomasoni S Longaretti L Azzollini N | 2004 | Am J Nephrol2004，24，3： | 1 |
| 18 | Epidemiologic surveillance of multidrug resistant Pseudomonas aeruginosa in Mantova Hospital (Italy)显示文摘 | Tomasoni D Gattuso G Chiarelli C | 2006 | Infez Med2006，14，2： | 1 |
| 19 | CTLA4Ig gene tranfer prologs survival and induced donor-spectific tolerance in a rat renal allograft显示文摘 | Tomasoni S Azzollini N Casiraghi F | 2000 | J Am Soc Nephrol2000，11，4： | 1 |
| 20 | 查看详情显示文摘 | Tomasoni S Longaretti L Azzollini N | | 0，，： | 1 |
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