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| 1 | Dyslipidaemia of diabetes and the intestine显示文摘Atherosclerosis is the major complication of diabetes and has become a major issue in the provision of medical care.In particular the economic burden is growing at an alarming rate in parallel with the increasing worldwide prevalence of diabetes.The major disturbance of lipid metabolism in diabetes relates to the effect of insulin on fat metabolism.Raised triglycerides being the hallmark of uncontrolled diabetes,i.e.,in the presence of hyperglycaemia.The explosion of type 2 diabetes has generated increasing interest on the aetiology ofatherosclerosis in diabetic patients.The importance of the atherogenic properties of triglyceride rich lipoproteins has only recently been recognised by the majority of diabetologists and cardiologists even though experimental evidence has been strong for many years.In the post-prandial phase 50% of triglyceride rich lipoproteins come from chylomicrons produced in the intestine.Recent evidence has secured the chylomicron as a major player in the atherogenic process.In diabetes chylomicron production is increased through disturbance in cholesterol absorption,in particular Neimann Pick C1-like1 activity is increased as is intestinal synthesis of cholesterol through 3-hydroxy-3-methyl glutaryl co enzyme A reductase.ATP binding cassette proteins G5 and G8 which regulate cholesterol in the intestine is reduced leading to chylomicronaemia.The chylomicron particle itself is atherogenic but the increase in the triglyceride-rich lipoproteins lead to an atherogenic low density lipoprotein and low high density lipoprotein.The various steps in the absorption process and the disturbance in chylomicron synthesis are discussed. | Gerald H Tomkin Daphne Owens | 2015 | World Journal of Diabetes2015，6，7： | 2 |
| 2 | Treatment of type 2 diabetes, lifestyle, GLP1 agonists and DPP4 inhibitors显示文摘In recent years the treatment focus for type 2 diabetes has shifted to prevention by lifestyle change and to more aggressive reduction of blood sugars during the early stage of treatment. Weight reduction is an important goal for many people with type 2 diabetes.Bariatric surgery is no longer considered a last resort treatment. Glucagon-like peptide-1 agonists given by injection are emerging as a useful treatment since they not only lower blood sugar but are associated with a modest weight reduction. The role of the oral dipeptidyl peptidase 4 inhibitors is emerging as second line treatment ahead of sulphonylureas due to a possible beneficial effect on the beta cell and weight neutrality.Drugs which inhibit glucose re-absorption in the kidney,sodium/glucose co-transport 2 inhibitors, may have a role in the treatment of diabetes. Insulin treatment still remains the cornerstone of treatment in many patients with type 2 diabetes. | Gerald H Tomkin | 2014 | World Journal of Diabetes2014，5，5： | 2 |
| 3 | An Integrated Genetic,Physical and Transcript Map of Homoeologous Chromosomes 12 and 26 in Upland Cotton(Gossypium hirsutum L.)显示文摘While Upland cotton(Gossypium hirsutum L.) represents 95% of the world production,its genetic improvement is hindered by the shortage of effective genomic tools and resources.The | KOHEL Russell J CHO Jaemin TOMKINS Jeffrey YU John Z | 2008 | 棉花学报2008，20，S1： | 2 |
| 4 | Treatment of functional gastrointestinal disorders with antidepressant medications : a meta-analysis 显示文摘 | JACKSON JL MALLEY PG TOMKINS G | 2000 | Am J Med2000，108，1： | 1 |
| 5 | Healthcare workers perceptions of occupational exposure to blood-borne viruses and reporting barriers:aquestionnaire-based study显示文摘 | Winchester SA Tomkins S Cliffe S | 2012 | J Hosp Infect2012，82，1： | 1 |
| 6 | Frequency, type, distribution and annotation of simple sequence repeats in Rosaceae ESTs显示文摘 | JUNG S ABBOTT A JESUDURAI C TOMKINS J MAIN D | 2005 | Funct Integr Genomics2005，5，： | 1 |
| 7 | Liquid Chromatographic Determination of Benzo(a)pyrene in the Total Particulate Matter of Cigarette Smoke显示文摘 | Tomkins B a Jenkins R A Gries W H | 1985 | J Assoc Off Anal Chem1985，68，： | 1 |
| 8 | Construction of plant bacterial artificial chromosome ( BAC ) libraries : An illustrated guide 显示文摘 | Peterson D G Tomkins J P Frisch D A | 2000 | Journal of Agricultural Genomics2000，5，： | 1 |
| 9 | The effect of high correlated color temperature office lighting on employee wellbeing and work performance显示文摘 | MILLS P R TOMKINS S C SCHLANGEN L J | 2007 | Journal of Circadian Rhythms2007，5，： | 1 |
| 10 | Blood - brain barrier breakdown following traumatic brain injury: A possible role in posttraumatic epilepsy显示文摘 | Tomkins O Feintueh A Benifla M | 2011 | Cardiovascular Psychiatry and Neurolo- gy2011，2，： | 1 |
| 11 | Hyperglycaemia : the relation to dyslipidaemia and atherosclerosis 显示文摘 | Tomkin GH | 2002 | Ir J Med Sci2002，171，3： | 1 |
| 12 | Centrat:5-HT receptor hypersensitivity in migraine without attra 显示文摘 | Cassidy EM Tomkins E Dinan T | 2003 | Cephalalgia2003，23，1： | 1 |
| 13 | Impact of zinc supplementation on persistent diarrhea in malnurished Bangladeshi children 显示文摘 | Roy SK Tomkins AM Mahalanabis D | 1998 | Acta Peadiatr1998，87，12： | 1 |
| 14 | Flexible facilities design显示文摘 | | 1980 | IIE Transactions1980，，12： | 1 |
| 15 | Cytogenetic aspects of the canadian early and mid-trimester amniotie fluid trial显示文摘 | Winsor E J Tomkins D J Kalousek D | 1999 | Prenat Diagn1999，19，7： | 1 |
| 16 | Human embryo fragmentation in vitro and its implications for pregnancy and implantation显示文摘 | ALIKANI M COHEN J TOMKIN G | 1999 | Ferti Steril1999，71，： | 1 |
| 17 | Vortex organization in the outer region of the turbulent boundary layer 显示文摘 | Adrian R J Meinhart C D Tomkins C D | 2000 | Journal of Fluid Mechanics2000，，422： | 1 |
| 18 | Human embryo fragmentation in vitro and its implications for pregnancy and implantation显示文摘 | Alikani M Cohen J Tomkin G | 1999 | Fertil Steril1999，71，5： | 1 |
| 19 | Treatment of Functional Gastrointestional Disorders with Antidepressant Medications: A Meta-Analysis显示文摘 | Jackson JL O'malley PG Tomkins G | 2000 | The Am J Med2000，108，： | 1 |
| 20 | Convergence clubs in the regions of Greece显示文摘 | Tomkins AJ | 2004 | Applied Economics Letters2004，11，： | 1 |
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