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| 1 | Coronary microvasculopathy in heart transplantation: Consequences and therapeutic implications显示文摘Despite the progress made in the prevention and treatment of rejection of the transplanted heart, cardiac allograft vasculopathy(CAV) remains the main cause of death in late survival transplanted patients. CAV consists of a progressive diffuse intimal hyperplasia and the proliferation of vascular smooth muscle cells, ending in wall thickening of epicardial vessels, intramyocardial arteries(50-20 μm), arterioles(20-10 μm), and capillaries(< 10 μm). The etiology of CAV remains unclear; both immunologic and non-immunologic mechanisms contribute to endothelial damage with a sustained inflammatory response. The immunological factors involved are Human Leukocyte Antigen compatibility between donor and recipient, alloreactive T cells and the humoral immune system. The non-immunological factors are older donor age, ischemia-reperfusion time, hyperlipidemia and CMV infections. Diagnostic techniques that are able to assess microvascular function are lacking. Intravascular ultrasound and fractional flow reserve, when performed during coronary angiography, are able to detect epicardial coronary artery disease but are not sensitive enough to assess microvascular changes. Some authors have proposed an index of microcircula-tory resistance during maximal hyperemia, which is calculated by dividing pressure by flow(distal pressure multiplied by the hyperemic mean transit time). Non-invasive methods to assess coronary physiology are stress echocardiography, coronary flow reserve by transthoracic Doppler echocardiography, single photon emission computed tomography, and perfusion cardiac magnetic resonance. In this review, we intend to analyze the mechanisms, consequences and therapeutic implications of microvascular dysfunction, including an extended citation of relevant literature data. | Alessandra Vecchiati Sara Tellatin Annalisa Angelini Sabino Iliceto Francesco Tona | 2014 | World Journal of Transplantation2014，4，2： | 3 |
| 2 | Differential patterns of contrast enhancement in different focal liver lesions after injection of the microbubble US contrast agent SonoVue显示文摘 | Quaia E Degobbis F Tona G | 2004 | Radiol Med2004，107，： | 1 |
| 3 | Plasma markers of en dothelial dysfunction in pulmonary hypertension显示文摘 | Bellotto F Tona F | 2001 | Chest2001，120，4： | 1 |
| 4 | Effects of genoty- peand feed allowance on plasma luteinizing hormones, follicle- stimulatinghormones, progesterone, estradiol levels, follicle differen- tiation,and egg production rates of broiler breeder hens显示文摘 | Onagbesan 0 M Metayer S Tona K | 2006 | Poul-try Science2006，85，： | 1 |
| 5 | Correlation between chemical composition and antibacterial activity of essential oils of some aromatic medicinal plants growing in the Democratic Republic of Congo 显示文摘 | Cimanga K Kambu K Tona L | 2002 | Journal of Ethnopharmacology2002，79，2： | 1 |
| 6 | Statistical analysis of the vehicle pollutant emissions derived from several European road tunnel studies 显示文摘 | COLBERG A Christina TONA Bruno CATONE Giovanni | 2005 | Atmospheric Environment2005，39，13： | 1 |
| 7 | Effects of genotype and feed allowance on plasma luteinizing hormones, follicle-stimulatinghormones, progesterone, estradiol levels, follicle differentiation, and egg production rates of broiler breeder hens 显示文摘 | Onagbesan O M Metayer S Tona K et d | 2006 | Poult Sci2006，85，： | 1 |
| 8 | Effects of sleep reduction on spatial attention显示文摘 | VERSACE F CAVALLERO C de MIN TONA G | 2006 | Biol-Psychol2006，71，3： | 1 |
| 9 | Clinical implications of anti- heart autoantibodies in myocarditis and dilated cardiomyopathy 显示文摘 | Caforio AL Tona F Bottaro S | 2008 | Autoimmunity2008，41，1： | 1 |
| 10 | Circulating cardiac autoantibod- ies in dilated cardiomyopathy and myocarditis:pathogenetic and clinical significance显示文摘 | C~orio AL Mahon NJ Tona F | 2002 | EurJ Heart Fail2002，4，4： | 1 |
| 11 | Sleep onset and cardiovascular activity in primary insomnia 显示文摘 | De Zambotti M Covassin N De Min Tona G | 2011 | J Sleep Re- search2011，20，2： | 1 |
| 12 | Evaluation of supplementary stevia ( Stevia rebaudiana, bertoni ) leaves and stevioside in broiler diets:effects on feed intake, nutrient metabolism, blood parameters and growth performance显示文摘 | Atteh J O Onagbesan 0 M Tona K | 2008 | Journal of Animal Physiology and Animal Nutrition2008，92，6： | 1 |
| 13 | Differential patterns of contrast enhancement in different focal liver lesions after injection of the microbubble US contrast agent SonoVue显示文摘 | Quaia E Degobbis F Tona G | 2004 | Radiol Med2004，107，3： | 1 |
| 14 | Correlation between chemical composition and antibacterial activity of essential oils of some aromatic medicinal plants growing in the Democratic Republic of Congo 显示文摘 | K Cimanga K Kambu L Tona | 2002 | Journal of Ethnopharmacology2002，79，： | 1 |
| 15 | Differential patterns of contrast enhancement in different focal liver lesions after injection of the microbubble US contrast agent SonoVue 显示文摘 | Quaia E Degobbis F Tona G | 2004 | Radiol Med2004，107，3： | 1 |
| 16 | Phytochemical screening and in vitro antiamoebic activity of extracts from some antidiarrhoeal medicinal plants used in Kinshasa, Democratic Republic of Congo 显示文摘 | Tona G L Cimanga R K Kambu O K | 2009 | Recent Progress in Medicinal Plants2009，25，： | 1 |
| 17 | Clmical implications of anti - heart autoantibodies in myocarditis and dilated cardiomyopathy 显示文摘 | Caforio AL Tona F Bottaro S | 2008 | Autoimmunity2008，41，1： | 1 |
| 18 | Differential patterns of contrast enhancement in different focal liver lesions after injection of the microbubble US contrast agent SonoVue显示文摘 | Quaia E Degobbis F Tona G | 2004 | Radial Med (Torino)2004，107，3： | 1 |
| 19 | Antiamoebic and phy- tochemical screening of some Congolese medicinal plants 显示文摘 | Tona L Kambu K Ngimbi N | 1998 | J Ethnopharmacol1998，61，1： | 1 |
| 20 | Differential patterns of contrast enhancement in different focal liver lesions after injec- tion of the microbubble US contrast agent SonoVue显示文摘 | Quaia E Degobbis F Tona G | 2004 | Radi- ol Med2004，107，15： | 1 |
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