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| 1 | Standardized training for resident doctors in China显示文摘Medical graduates are not fully trained physicians when they leave medical school.Currently,standardized training for resident doctors in most hospitals in China is carried out according to the Ministry of Health guidelines.However,these guidelines provide only outline guidance,and specific resident training is managed independently by and varies with individual institutions.Therefore,it is important to study training demand to learn about the content and emphasis of training. | Tonglin Sun Yanqing Wang | 2014 | The Journal of Biomedical Research2014，28，3： | 23 |
| 2 | Altered expression of mitochondrial related genes in the native Tibetan placents by mitochondrial cDNA array analysis显示文摘Objective: To explore the mechanism of native Tibetan fetuses adaptation to hypoxia, we tried to find the different expression genes about mitochondrial function in the native Tibetan placents. Methods: In this study, the placents of native Tibetan and the high-altitude Han (ha-Han) were collected. After the total RNA extraction, the finally synthesized cDNAs were hybridized to mitochondrial array to find the altered expression genes between them. Then, the cytochrome c oxidase 17 (Cox17), dynactin 2 (DCTN2, also known as p50), and vascular endothelial growth factor receptor (VEGFR, also known as KDR) were chosen from the altered expression genes to further verify the array results using the SYBR Green real-time PCR. Because the altered expression genes (such as Cybb and Cox17) in the array results related to the activities of COXI and COXIV, the placental mitochondria activities of COXI and COXIV were measured to find their changes in the hypoxia. Results: By a standard of ≥1.5 or ≤0.67, there were 24 different expressed genes between the native Tibetan and the ha-Han placents, including 3 up-regulated genes and 21 down-regulated genes. These genes were related to energy metabolism, signal transduction, cell proliferation, electron transport, cell adhesion, nucleotide-excision repair. The array results of Cox17, DCTN2 and KDR were further verified by the real-time RT-PCR. Through the mitochondria respiration measurements, the activity of COXI in the native Tibetan placents were higher than that of ha-Han, there was no difference in COXIV activity between them. Conclusion: The altered mitochondrial related genes in the native Tibetan placents may have a role in the high altitude adaptation for fetuses through changing the activity of mitochondrial COX. | Luo Yongjun Gao Wenxiang Zhao Xiuxin SUO Lang Chen Li Liu Fuyu Song Tonglin Chen Jian Gao Yuqi | 2009 | Journal of Medical Colleges of PLA(China)2009，24，1： | 7 |
| 3 | Higher-Ordered Actin Structures Remodeled by Arabidopsis ACTIN-DEPOLYMERIZING FACTOR5 Are Important for Pollen Germination and Pollen Tube Growth显示文摘肌动朊细胞骨架的动力学为花粉萌芽和花粉试管生长是必要的。使解聚肌动朊的因素(ADF ) 典型地由切断 / 使解聚肌动朊细丝贡献肌动朊周转。最近,我们证明 Arabidopsis 亚纲 III ADF (ADF5 和 ADF9 ) 从保存 F-actin-depolymerizing 功能发展了 F-actin-bundling 功能。然而,很少对生理的功能,进化意义,和这些 neofunctionalized ADF 的肌动朊捆绑机制被知道。这里,我们报导 ? 引起的 ADF5 功能的那损失推迟了花粉萌芽,延迟的花粉试管生长,并且增加对由影响肌动朊捆的产生和维护的 latrunculin B (LatB ) 处理敏感。在生活房间的肌动朊细丝动力学的检查表明捆绑频率显著地在 adf5 花粉试管被减少,与它的生物化学的功能一致。进一步生物化学、基因的互补分析 ? 两个都表明了那 N-? 并且 ADF5 的 C 终端肌动朊绑定域为它的生理、生物化学的函数被要求。有趣地,当两个是不正常的肌动朊捆绑 ADF, ADF5,然而并非 ADF9 时,在成熟花粉起一个重要作用生理的活动。一起拿,我们的结果建议 ADF5 发展了捆绑肌动朊细丝的功能并且在花粉萌芽和花粉试管生长期间在肌动朊捆的形成,组织,和维护起一个重要作用。 | Jingen Zhu Qiong Nan Tao Qin Dong Qian Tonglin Mao Shunjie Yuan Xiaorong Wu Yue Niu Qifeng Bai Lizhe An Yun Xiang | 2017 | Molecular Plant2017，10，8： | 6 |
| 4 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 5 | Digital Geological Mapping of Sinus Iridum Area of the Moon Based on the Chang'E-I Data显示文摘Based on the CCD images,IIM data and DEM data of China’s lunar exploration project(Chang’E-I)and related processed and analytic results,an integrated study of regional geology of Sinus Iridum and its adjacent area was conducted,and a series of relevant researches and analyses were carried out,including analysis of impact craters and their extrusive and accumulative materials,division of stratigraphic and tectonic units and classification of rock types,integrated analysis of chronology and lunar evolution history.In consideration of crater’s shape features,quantity and preserving status of filling materials,the lunar impact craters can be divided into 7 types and 11 subtypes,and the accumulative materials of craters are divided into 6 types and 9 accumulative groups.According to the content and distribution of TiO2and image characteristics,the basalts are divided into high-TiO2,medium-TiO2and low-TiO2basalts.Discussion was made on division of tectonic units and evolution features in the study area.The geological map of the Sinus Iridum Quadrangle(LQ-4)at a scale of 1:2.5 M was preliminarily compiled with the ArcGIS system,and the spatial database of the map was established.Related technical specification,procedure and method for lunar geological mapping have been worked out,so as to lay a foundation for the forthcoming geological mapping of the global Moon in China by using the data of Chang’E-II and also for comprehensive study and geological mapping of other celestial bodies in the future. | DING Xiaozhong HAN Kunying PANG Jianfeng WANG Liang HAN Tonglin JU Yuanjing DING Weicui | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 3 |
| 6 | Changes in secretory pathway Ca^(2+)-ATPase 2 following focal cerebral ischemia/reperfusion injury显示文摘This study aimed to investigate changes in secretory pathway Ca2+-ATPase 2 expression following cerebral ischemia/reperfusion injury, and to define the role of Ca2+-ATPases in oxidative stress. A rat model of cerebral ischemia/reperfusion injury was established using the unilateral middle cerebral artery occlusion method. Immunohistochemistry and reverse transcription-PCR assay results showed that compared with the control group, the expression of secretory pathway Ca2+-ATPase 2 protein and mRNA in the cerebral cortex and hippocampus of male rats did not significantly change during the ischemic period. However, secretory pathway Ca2+-ATPase 2 protein and mRNA expression reduced gradually at 1, 3, and 24 hours during the reperfusion period. Our experimental findings indicate that levels of secretory pathway Ca2+-ATPase 2 protein and mRNA expression in brain tissue change in response to cerebral ischemia/reperfusion injury. | Tonglin Lu Zhiping Hu Liuwang Zeng Zheng Jiang | 2013 | Neural Regeneration Research2013，8，1： | 2 |
| 7 | Data analysis of 36 cases with intraductal papillary mucinous neoplasm of the pancreas for their clinicopathological features, diagnosis, and treatment显示文摘 | Yuan Chunhui Xiu Dianrong Tao Ming Ma Zhaolai Jiang Bin Li Zhifei Li Lei Wang Liang Wang Hangyan Zhang Tonglin | 2014 | Chinese Medical Journal2014，，23： | 2 |
| 8 | MDP25 mediates the fine-tuning of microtubule organization in response to salt stress显示文摘Microtubules are dynamic cytoskeleton structures playing fundamental roles in plant responses to salt stress.The precise mechanisms by which microtubule organization is regulated under salt stress are largely unknown.Here,we report that Arabidopsis thaliana MICROTUBULE-DESTABILIZING PROTEIN 25(MDP25;also known as PLASMA MEMBRANEASSOCIATED CATION-BINDING PROTEIN 1(PCaP1))helps regulate microtubule organization.Under salt treatment,elevated cytosolic Ca^(2+) concentration caused MDP25 to partially dissociate from the plasma membrane,promoting microtubule depolymerization.When Ca^(2+) signaling was blocked by BAPTA-AM or LaCl_(3),microtubule depolymerization in wild-type and MDP25-overexpressing cells was slower,while there was no obvious change in mdp25 cells.Knockout of MDP25 improved microtubule reassembly and was conducive to microtubule integrity under long-term salt treatment and microtubule recovery after salt stress.Moreover,mdp25 seedlings exhibited a higher survival rate under salt stress.The presence microtubule-disrupting reagent oryzalin or microtubule-stabilizing reagent paclitaxel differentially affected the survival rates of different genotypes under salt stress.MDP25 promoted microtubule instability by affecting the catastrophe and rescue frequencies,shrinkage rate and time in pause phase at the microtubule plus-end and the depolymerization rate at the microtubule minus-end.These findings reveal a role for MDP25 in regulating microtubule organization under salt treatment by affecting microtubule dynamics. | Peizhi Yang Jingwei Jin Jingru Zhang Dan Wang Xuechun Bai Wenfei Xie Tianming Hu Xuan Zhao Tonglin Mao Tao Qin | 2022 | Journal of Integrative Plant Biology2022，64，6： | 1 |
| 9 | Ultrasound probe pressure but not maternal Valsalva maneuver alters Doppler parameters during fetal middle cerebral artery Doppler ultrasonography显示文摘 | Yi‐MingSu Guo‐RongLv Xiao‐KangChen Shao‐HuiLi Hui‐TongLin | 2010 | Prenat Diagn (鈥?)2010，，12： | 1 |
| 10 | Geoelectrical structures of northern segment of Tan-Lu fault system in China and Russia areas based on magnetotelluric soundings显示文摘From China to Russia,Tan-Lu fault system stretches for thousands of kilometers,towards NE 30°.The authors have collected more than ten magnetotelluric profile that China and Russia have carried out,in the studied area of the Tan-Lu fault's northern section,and have analyzed electrical characteristics of the relevant profiles.Deriving the following conclusions:(1)Jiamusi-Bureya plots,etc.,demonstrate the high resistance of Kernel;(2)Fold belt attributed to the land showed high and low resistance stitching,associated with not only terrane accretion,but also upper mantle upwelling;below the sedimentary basin,the resistivity of the upper mantle is lower and closer to the surface comparing with the adjacent area(100-150);(3)In the system of Tan-Lu fracture,Yishu and Dunmi fracture,etc.are expressed as vertical low-resistivity zone;(4)There may exist subducted old-fashioned piece under Jiamusi and Bureya plots. | V.B.Kaplun G.L.Kirillova LI Tonglin | 2013 | Global Geology2013，16，3： | 1 |
| 11 | Nickel-boron alloy catalysts reduce the formation of trans fatty acids in hydrogenated soybean oil显示文摘 | LI Tonglin ZHANG Weinong LEE R Z | 2009 | Food Chemistry2009，114，2： | 1 |
| 12 | Credible and confidence sets for restricted parameter spaces显示文摘 | Zhang Tonglin Michael Woodroofe | 2000 | Journal of Statistical Planning and Inference2000，115，： | 1 |
| 13 | Structure and evolution of the Himalaya-Tibet orogenic belt 显示文摘 | Allegre C J Courtillot V Tapponnier L Him A Mattauer M Coulon C Jaeger J J Achache J Scharer U Marcoux J Burg J L Girardeau J Armijo R Gariepy C Gopel C Li Tindong Xiao Xuchang Chang Chenfa Li Guangqin Lin Baoyu Teng Jiwen Wang Naiwen Chert Guoming Hart Tonglin Wang Xibin Den Wanming Sheng Huaibin Cao Yougong Zhou Ji Qiu Hongrong Bao Peisheng Wang Songchan Wang Bixiang Zhou Yaoxiu RonghuaXu | 1984 | Nature1984，307，5946： | 1 |
| 14 | Late Cenozoic Right-Lateral Strike-Slip Faulting in Southern Tibet显示文摘 | Armijo R Tapponnier P Han Tonglin | 1989 | Journal of Geophysical Research1989，94，： | 1 |
| 15 | Modeling for the Effect of Magnetotelluric 3D Topography Based on the Vector Finite-Element Method 显示文摘 | Gu Guanwen Wu Wenli Li Tonglin | 2014 | Journal of Jilin University ( Earth Science Edition)2014，44，5： | 1 |
| 16 | Column nmgnetic sepa- rator and its application 显示文摘 | Chen Guangzhen Zhao Tonglin Liu Bingyu | 2002 | Journal of Iron and Steel Research2002，，6： | 1 |
| 17 | Research on modeling source effect of 3D CSAMT based on staggered-grid finite difference method显示文摘There is usually source effect in the field work of controlled-source audio-frequency magnetotelluric method.Source effect is a thorny problem during field working,data processing and interpretation.Therefore,it is very important for the results of field prospecting to model source effect and summarize its influence rules.Based on the previous research,the authors use 3D finite difference method to simulate the electromagnetic field and set different anomaly situation to study the source effect in near-field measurement,then conclude the influence rules of source effect.Simulations provide the reference for the actual field work and data processing to correct the influence of source effect,so the information of the underground will be more approaching to the real. | ZHANG Heng LI Tonglin | 2017 | Global Geology2017，20，1： | 1 |
| 18 | Wavelet Numerical Solutions for Weakly Singular Fredholm Integral Equations of the Second Kind显示文摘Daubechies interval wavelet is used to solve numerically weakly singular Fredholm integral equations of the second kind. Utilizing the orthogonality of the wavelet basis,the integral equation is reduced into a linear system of equations. The vanishing moments of the wavelet make the wavelet coefficient matrices sparse,while the continuity of the derivative functions of basis overcomes naturally the singular problem of the integral solution. The uniform convergence of the approximate solution by the wavelet method is proved and the error bound is given. Finally,numerical example is presented to show the application of the wavelet method. | TANG Xinjian PANG Zhicheng ZHU Tonglin LIU Jian | 2007 | Wuhan University Journal of Natural Sciences2007，12，3： | 1 |
| 19 | Arabidopsis Profilin Isoforms,PRF1 and PRF2 Show Distinctive Binding Activities and Subcellular Distributions显示文摘Profilin is an actin-binding protein that shows complex effects on the dynamics of the actin cytoskeleton. There are five profilin isoforms in Arabidopsis thaliana L. However, it is still an open question whether these isoforms are functionally different. In the present study, two profilin isoforms from Arabidopsis, PRF1 and PRF2 were fused with green fluorescent protein (GFP) tag and expressed in Escherichia coli and A. thaliana in order to compare their biochemical properties in vitro and their cellular distributions in vivo. Biochemical analysis revealed that fusion proteins of GFP-PRF1 and GFP-PRF2 can bind to poly-L-proline and G-actin showing remarkable differences. GFP-PRF1 has much higher affinities for both poly-L-proline and G-actin compared with GFP-PRF2. Observations of living cells in stable transgenic A. thaliana lines revealed that 35S::GFP-PRF1 formed a filamentous network, while 35S::GFP-PRF2 formed polygonal meshes. Results from the treatment with latrunculin A and a subsequent recovery experiment indicated that filamentous alignment of GFP-PRF1 was likely associated with actin filaments. However, GFP-PRF2 localized to polygonal meshes resembling the endoplasmic reticulum. Our results provide evidence that Arabidopsis profilin isoforms PRF1 and PRF2 have different biochemical affinities for poly-L-proline and G-actin, and show distinctive localizations in living cells. These data suggest that PRF1 and PRF2 are functionally different isoforms. | Feng ang Yanping Jing Zhen ang Tonglin Mao Jozef Samaj Ming Yuan Haiyun Ren | 2009 | Journal of Integrative Plant Biology2009，51，2： | 1 |
| 20 | Assembly stresses and the strength of hollow iron (press rolls)显示文摘 | Shu Tonglin Miao Dehua Zhang Dongjun Gu Dequan | 1995 | Tappi Journal1995，78，3： | 1 |
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