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| 1 | Apple dwarfing rootstocks exhibit an imbalance in carbohydrate allocation and reduced cell growth and metabolism显示文摘Apple dwarfing rootstocks cause earlier shoot termination and reduced root and shoot mass.To identify physiological factors responsible for rootstock-induced growth restriction,we compared vascular-enriched gene expression between two dwarfing rootstocks(‘M27’and‘M9’)and the vigorous rootstock‘M793’using RNA sequencing and quantitative reverse transcriptase PCR.Differentially expressed genes common to both dwarfing rootstocks belonged to five main biological processes:(1)primary metabolism,(2)cell wall synthesis and modification,(3)secondary metabolism,(4)hormone signalling and response and(5)redox homeostasis.Genes promoting the biosynthesis of amino acids,lipids and cell walls were downregulated in dwarfing rootstocks,whereas genes promoting the breakdown of these compounds were upregulated.The only exception to this trend was the upregulation of starch synthesis genes in dwarfing rootstocks.Non-structural carbohydrate analysis demonstrated that starch concentrations in‘M9’roots,stems and grafted‘Royal Gala’(‘RG’)scions were double that of equivalent tissues from‘RG’homo-grafted trees(‘RG’/‘RG’).Fructose and glucose concentrations were much lower in all three tissues of the‘RG’/‘M9’trees.Together,these data indicate that dwarfing rootstocks are in a state of sugar depletion and reduced cellular activity despite having large starch reserves.Another significant finding was the over-accumulation of flavonoids and the downregulation of auxin influx transporters MdAUX1 and MdLAX2 in dwarfing rootstocks.We propose that both factors reduce polar auxin transport.The results of this study contribute novel information about the physiological state of dwarfing rootstocks. | Toshi M Foster Peter A McAtee Chethi N Waite Helen L Boldingh Tony K McGhie | 2017 | Horticulture Research2017，4，1： | 4 |
| 2 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 3 | Differential Neurotoxic Effects of Propofol on Dissociated Cortical Cells and Organotypic Hippocampal Cultures显示文摘 | Spahr Schopfer I Vutskits L Toni N | 2000 | Anesthesiology2000，92，5： | 1 |
| 4 | Intravenous thrombolysis in young stroke patients: results from the SITS-ISTR显示文摘 | TONI D AHMED N ANZINI A | 2012 | Neurology2012，78，12： | 1 |
| 5 | Does nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae?显示文摘 | Hanne B. Albert Peter Lambert Jess Rollason Joan Solgaard Sorensen Tony Worthington Mogens Bach Pedersen Hanne Schack N?rgaard Ann Vernallis Frederik Busch Claus Manniche Tom Elliott | 2013 | European Spine Journal2013，，4： | 1 |
| 6 | Angiotensin II sustains brain inflammation in mice via TGF-[Beta]显示文摘 | Lanz Tobias V Ding Zhaoqing Ho Peggy P Luo Jian Agrawal Ankur N Srinagesh Hrishikesh Axtell Robert Zhang Hui Platten Michael Wyss-Coray Tony Steinman Lawrence | 2010 | Journal of Clinical Investigation2010，，8： | 1 |
| 7 | Differential neurotoxic effects of propofol on dissociated cortical cells and organotypic hippocampal cultures显示文摘 | Spahr-Schopfer I Vutskits L Toni N | 2000 | Anesthesiology2000，92，5： | 1 |
| 8 | Measurement of DNA copy number at microsatellite loci using quantitative PCR anal-ysis显示文摘 | David G G Tony E G Janice N | 2000 | Cancer Research2000，60，： | 1 |
| 9 | Integrins are involvedin synaptogenesis, cell spreading, and adhesion in the postnatalbrain 显示文摘 | Nikonenko I Toni N Moosmayer M | 2003 | Brain Res Dev Brain Res2003，140，2： | 1 |
| 10 | Pointing acquisition and tracking system for the free space laser communication system显示文摘 | | 2001 | SILEX SPIE2001，2381，： | 1 |
| 11 | Neurons born in the adultdentate gyrus form functional synapseswithtarget cells显示文摘 | Toni N Laplagne D A Zhao C | 2008 | NatNeurosci2008，11，8： | 1 |
| 12 | Remodeling of synaptic membranes after induction of long-term potentiation显示文摘 | Toni N Buchs PA Nikonenko I | 2001 | J Neurosci2001，21，16： | 1 |
| 13 | Properties of HTS for successful U/n processing显示文摘 | Weinstein R Ren Y Sawh R Gandini A Henning W Murakami M Mochida T Chikumoto N Sakai N Krabbes G Bieger W Milliken D Dou S X Tonies S Eis terer M Weber H | | 0，，： | 1 |
| 14 | Enhanced hippocampal longterm potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice显示文摘 | Hulo S Toni N | 1999 | EMBOJ1999，18，11： | 1 |
| 15 | NMDA-receptor-mediated,cell-specific integration of new neurons in adult dentate gyrus显示文摘 | Tashiro A Sandler VM Toni N | 2006 | Nature2006，442，： | 1 |
| 16 | Presence of CRF09_epx and complex CRF02_AG/CRF09_cpx recombinant HIV type 1 strains in Cote d'Ivoire,West Africa显示文摘 | Toni T Adje-Toure C Vidal N | 2005 | AIDS Res Hum Retroviruses2005，21，7： | 1 |
| 17 | Development of func- tional human embryonic stem cell-derived neurons in mouse brain 显示文摘 | Muotri A R Nakashima K Toni N | 2005 | Proc Natl Acad Sci USA2005，102，18： | 1 |
| 18 | Synapse formation on neurons born in the adult hippocampus显示文摘 | Toni N Teng EM Bushong EA | 2007 | Nat Neurosci2007，10，72： | 1 |
| 19 | Directed differentiation of hippocampal stem/progenitor cells in the adult brain显示文摘 | Jessberger S Toni N Clemenson GD | 2008 | Nat Neurosci2008，11，： | 1 |
| 20 | Seizure-associated,aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling显示文摘 | Jessberger S Zhao C Toni N Clemenson GD Jr Li Y Gage FH | 2007 | J Neurosci2007，27，： | 1 |
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