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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Inheritance ofroot characters and their relations to drought resistance in rice 显示文摘 | Ekanayake I J Toole J C 0 G arrity D P’Masajc T M | 1985 | Crop Science1985，25，6： | 1 |
| 3 | FRVT 2006 and ICE 2006 large-scale ex- perimental results显示文摘 | Phillips P J Scruggs T O'Toole A Flynn P J Bowyer K W Sehott C Sharpe M | 2010 | IEEE Transactions on Pattern Analysis and Machine Intelligence2010，32，5： | 1 |
| 4 | Biofilms strike back显示文摘 | O'Toole G A Stewart P S | 2005 | Nat Bio technol2005，23，11： | 1 |
| 5 | Photolysis and the dirnethylsulfide (DMS) summer paradox in the Sargasso Sea显示文摘 | TOOLED A KIEBER D J KIENE R P | 2003 | Lim- nology and Oceanography2003，48，3： | 1 |
| 6 | Inhibition of tumor growth in vivo by hyaluronan oligomers 显示文摘 | Zeng C Toole B P Kinney S D | 1998 | Int J Cancer1998，77，： | 1 |
| 7 | Expression of emmprin ( CD147), a cell surface inducer of matriax metallopro- teinases in normal human brain and gliomas 显示文摘 | Sameshima T Nabeshima K Toole B P | 2000 | Int J Cancer2000，88，1： | 1 |
| 8 | Flow cytometric determination of residual white hlood cell levels in preserved samples from leukoreduced blood products 显示文摘 | Palmer DS Birch P O'Toole J | 2008 | Transfusion2008，48，1： | 1 |
| 9 | Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-κB dependent mechanism显示文摘 | O′Toole D Hassett P Contreras M | 2009 | Thorax2009，64，： | 1 |
| 10 | Selection for reproductive stage drought avoidance in rice using infrared thermometry显示文摘 | Garrity D P O Toole J C | 1995 | Agron J1995，87，： | 1 |
| 11 | Is Public R&D a Com- plement or Substitute for Private R&D? A Review of the Econometric Evidence 显示文摘 | David P A Hall B H Toole A A | 2000 | Research Policy2000，29，45： | 1 |
| 12 | Is public R&D a com- plement or substitute for private R&D? a review of econ- ometric evidence 显示文摘 | David P A Hall B H Toole A | 2000 | Research Policy2000，29，4： | 1 |
| 13 | Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients显示文摘 | Cundy KC Barditch-Crovo P Walker RE Collier AC Ebeling D Toole J | 1995 | Antimicrob Agents Chemother1995，39，： | 1 |
| 14 | Emmprin (CD147), a cell surface regulator of matrix metalloproteinase production and function显示文摘 | Bryan P Toole | 2003 | Current Topics in Developmental Biology2003，，： | 1 |
| 15 | Inheritance of root characters and their relations to drought resistance in rice显示文摘 | Ekanayake I J O'Toole J C Gritty D P | 1985 | Crop Sci1985，25，： | 1 |
| 16 | Correlation of emmprin expression in vascular endothelial cells with blood-brain-barrier function: a study using magnetic resonance imaging enhanced by Gd-DTPA and immunohistochemistry in brain tumors显示文摘 | Sameshima T Nabeshima K Toole B P | 2003 | Virchows Arch2003，442，6： | 1 |
| 17 | Glioma cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates production of membrane-type matrix mctalloproteinascs and activated gelatinase A in co-cultures with brain-derived fibroblasts 显示文摘 | Saineshima T Nabeshima K Toole B P | 2000 | Cancer Lett2000，157，2： | 1 |
| 18 | Hyaluronan:from extracellular glue to pericellular cue显示文摘 | TOOLE B P | 2004 | Nat Rev Cancer2004，4，： | 1 |
| 19 | Hyaluronan-cell in- teractions in cancer and vau|ar disea 显示文摘 | TOOLE B P WIGHT T N TAMMI M I | 2002 | J Biol Chem2002，277，7： | 1 |
| 20 | Hyaluronan and tumor growth 显示文摘 | TOOLE B P HASCALL V C | 2002 | Am J Patho12002，161，3： | 1 |
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