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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Intracralial Delivery of the Nitric Oxide Donor Diethylenetriamine/nitrie Oxide from a Controlledreleasw Polymer : Toxicity in Cynomolgus Monkeys显示文摘 | Travis S Tierney M D | 2006 | Neurosurgery2006，58，： | 1 |
| 3 | Expression of surfactant associ-ated protein-A and Clara cell 10 kilodahon mRNA in neoplastic and non-neoplastichuman lung tissue as detected by in situ hybridization 显示文摘 | Broers J L Jensen S M Travis W D | 1992 | Lab Invest1992，66，3： | 1 |
| 4 | Evidence that monoclonal antibodies directed against the integrin β subunit plexin/ semaphorin/integrin domain stimulate function by inducing receptor extension显示文摘 | Mould A P Travis M A Barton S J | 2005 | J Biol Chem2005，280，6： | 1 |
| 5 | Interactive effects of temperature and salinity on otolithchemistry:challenges for determining environmental histories of fish显示文摘 | Elsdon Travis S Gillanders Bronwyn M | 2002 | Canadian Journal of Fish-eries and Aquatic Sciences2002，59，： | 1 |
| 6 | Global Stability of a Biological Model with Time Delay 显示文摘 | Lenhart S M Travis C C | 1986 | Proc Amer Math Soc1986，96，1： | 1 |
| 7 | A high-density soybean genetic map based on AFLP markers 显示文摘 | Keim P Schupp J M Travis S E | 1997 | Crop Sci1997，37，： | 1 |
| 8 | Kinetics of catalyzed acid/acid and acid/aldehyde condensation reactions to non-symmetric ketones显示文摘 | Travis S H Dooley K M | 2003 | Catalysis Today2003，85，234： | 1 |
| 9 | Guidelines for themanagement of inflammatory bowel disease in adults显示文摘 | Carter M J Lobo A J Travis S P L | 2004 | Gut2004，53，9： | 1 |
| 10 | Primitive hematopoietic cells in murine bone marrow express the CD34 antigen显示文摘 | Morel F Szilvassy S J Travis M | 1988 | Blood1988，，10： | 1 |
| 11 | Introducing a stochastic movement simulator/ for estimatinghabitat connectivity 显示文摘 | Palmer S C F Coulon A Travis J M J | 2011 | Methods in Ecology and Evolution2011，2，3： | 1 |
| 12 | Cancer surveillance series:non-Hodgkin's lymphoma incidence by histologic subtype in the United States from 1978 through 1995显示文摘 | Groves F D Liner M S Travis L B | 2000 | J Natl Cancer Inst2000，92，15： | 1 |
| 13 | Antecedents and sex/gender differences in youth suicidal behavior显示文摘Suicide is the second leading cause of death in youth globally; however, there is uncertainty about how best to intervene. Suicide rates are typically higher in males than females, while the converse is true for suicide attempts. We review this 'gender paradox' in youth, and in particular, the age-dependency of these sex/gender differences and the developmental mechanisms that may explain them. Epidemiologic, genetic,neurodevelopmental and psychopathological research have identified suicidal behaviour risks arising from genetic vulnerabilities and sex/gender differences in early adverse environments, neurodevelopment, mental disorder and their complex interconnections. Further, evolving sex-/gender-defined social expectations and norms have been thought to influence suicide risk. In particular, how youth perceive and cope with threats and losses(including conforming to others' or one's own expectations of sex/gender identity) and adapt to pain(through substance use and helpseeking behaviours). Taken together, considering brain plasticity over the lifespan, these proposed antecedents to youth suicide highlight the importance of interventions that alter early environment(s)(e.g., childhood maltreatment) and/or one's ability to adapt to them. Further, such interventions may have more enduring protective effects, for the individual and for future generations, if implemented in youth. | Anne E Rhodes Michael H Boyle Jeffrey A Bridge Mark Sinyor Paul S Links Lil Tonmyr Robin Skinner Jennifer M Bethell Corine Carlisle Sarah Goodday Travis Salway Hottes Amanda Newton Kathryn Bennett Purnima Sundar Amy H Cheung Peter Szatmari | 2014 | World Journal of Psychiatry2014，4，4： | 1 |
| 14 | Radical change accidentally: The emergence and amplification of small change显示文摘 | Plowman D Baker L T Beck T Kulkami M Solansky S and Travis D | 2007 | Academy of Management Journal2007，50，3： | 1 |
| 15 | Peptide-nucleic acid-mediated enriched polymerase chain reaction as a key point for non-invasive prenatal diagnosis of beta-thalassemia显示文摘 | Galbiati S Foglieni B Travi M | 2008 | Haematologica2008，93，4： | 1 |
| 16 | A high_density soybean genetic map bsed on AFLP marker显示文摘 | KEIM P SCHUPP J M TRAVIS S E | 1997 | Crop Sciences1997，37，2： | 1 |
| 17 | A maximum entropy-least squares estimator for elastic origin-destination trip matrix estimation显示文摘 | Xie C Kockelman K M Travis Waller S | | 0，，： | 1 |
| 18 | Guidelines for the management of inflammatory bowel disease in adults 显示文摘 | Carter M J Lobo A J Travis S P L | 2004 | Gut2004，53，9： | 1 |
| 19 | European evidence based consensus on the diagnosis and management of Crohn's disease: current management显示文摘 | Travis S P L Stange E F Lemann M | 2006 | Gut2006，55，1： | 1 |
| 20 | A high - density soybean genetic map based on AFLP markers显示文摘 | Keim P Schupp J M Travis S E | 1997 | Crop Science1997，37，2： | 1 |
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