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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 3 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 4 | Performance of Neural Network: Mapping Forests Using GIS and Remotely Sensed Data 显示文摘 | Skidmore A Turner B Brinkhof W Knowles E | 1997 | ISPRS Journal of Photogrammetric Engineering & Remote Sensing1997，63，： | 2 |
| 5 | Interactions between crop residue and soil organic matter quality and the functional diversity of soil microbial communities显示文摘 | BENDING G D TURNER M K JONES J E | 2002 | Soil Boil Biochem2002，34，： | 1 |
| 6 | Illustrating the coupled human-environment system for vulnerability analysis three case studies显示文摘 | Turner II BL Roger E K Pamela A M | 2003 | The Proceedings of the National Academy of Sciences2003，14，： | 1 |
| 7 | The jasmonate signal pathway显示文摘 | John Turner G Christine E Alessandra D | 2002 | Plant Cell2002，14，： | 1 |
| 8 | Pyrazolopyridine antiherpetics: SAR of C2 ' and C7 amine substituents显示文摘 | Johns B A Gudmundsson K S Turner E M | 2005 | Bioorganic & Medicinal Chemistry2005，13，： | 1 |
| 9 | Stoichiometric nutrient bal-ance and origin of coastal eutrophication 显示文摘 | Justi D Rabalais N N> Turner R E | 1995 | Marine PollutionBulletin1995，30，1： | 1 |
| 10 | Hypoxia in the northern gulf of Mexico:does the science support the plan to reduce, mitigate, and control hypoxia?显示文摘 | RABALAIS N N TURNER R E SEN GUPTA B K | 2007 | Estuaries and Coasts2007，30，5： | 1 |
| 11 | Sensitivity of methane hy- drate phase equilibrium to the sediment pore size 显示文摘 | Turner D J Cherry R S Sloan E D | 2005 | Fluid Phase Equilibria2005，228，： | 1 |
| 12 | The effect of music amplitude on the reaction to unexpected visual events显示文摘 | Turner M L Fernandez J E Nelson K | 1996 | The Journal of General Psychol ogy1996，123，1： | 1 |
| 13 | Plant-water relations and adaptation 显示文摘 | Turner N C John E B | 1981 | Plant and Soi11981，58，13： | 1 |
| 14 | Structural analysis of metamorphic tectonites 显示文摘 | Turner F J Weiss L E | 1963 | Literary Licensing1963，，： | 1 |
| 15 | Unwrapping noisy phase maps by use of a minimum- cost-matching algorithm 显示文摘 | Buchnland J R Huntley J M Turner S R E | 1995 | Appl Opt1995，34，23： | 1 |
| 16 | Plant-water relations and adoption to stress显示文摘 | Turner N C Begg J E | 1981 | Plant and Soil1981，58，13： | 1 |
| 17 | The cause of land use and land cover change: Moving beyond the myths显示文摘 | Lambin E F Turner B L Geist H J | 2001 | Global Environment Change2001，11，4： | 1 |
| 18 | Angiogenesis in pituitary adenomas and the normal pituitary gland显示文摘 | Turner H E Nagy Z Gatter K C | 2000 | J Clin Endocrinol Metab2000，85，3： | 1 |
| 19 | Carbon,water and nutrient relations of two mistletoes and their hosts,a hypothesis显示文摘 | Schulze E D Turner N C Glatzel G | 1984 | Plant Cell Environ1984，143，： | 1 |
| 20 | Cell culture of Isospora from the English sparrow,Passer domesticus domesticus显示文摘 | Turner M B Box E D | 1970 | J Parasitol1970，56，6： | 1 |
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