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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism显示文摘 | Grunwald U Fan X Jack RS | 1996 | J Immunol1996，157，9： | 1 |
| 3 | Fluorine-18 fluorodeoxyglucose positron emission tomography in thyroid cancer: results of a multicenter study显示文摘 | Grunwald F Kalicke T Feine U et al | 1999 | Eur J Nucl Med1999，26，： | 1 |
| 4 | Functional status of peripheral blood T-cells in ischemic stroke patients显示文摘 | Vogelgesang A May VE Grunwald U | 2010 | PLoS One2010，5，： | 1 |
| 5 | Effects of hexadecylphosphocholine on membrane phospholipid metabolism in human tumour cells显示文摘 | Grunwald U Menzel W | 1995 | Eur J Cancer1995，31，12： | 1 |
| 6 | Analysisof lymphocyte subsets in patients with stroke and their in-fluence on infection after stroke 显示文摘 | Vogelgesang A Grunwald U LangnerS | 2008 | Stroke2008，39，1： | 1 |
| 7 | Functional status of peripheral blood T-Cells in ischemic stroke patients显示文摘 | Vogelgesang A May VE Grunwald U | 2010 | PLoS One2010，5，1： | 1 |
| 8 | Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke显示文摘 | Vogelgesang A Grunwald U Langner S | 2008 | Stroke2008，39，1： | 1 |
| 9 | Over- lapping expression patterns and differential transcript levels of phosphate transporter genes in arbuseular mycorrhizal, Pi-fertilised and phytohormone-treated Medicago truncatula roots 显示文摘 | GRUNWALD U GUO W B FISCHER K | 2009 | Planta2009，229，5： | 1 |
| 10 | A- nalysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke显示文摘 | VOGELGESANG A GRUNWALD U LANGNER S | 2008 | Stroke2008，39，： | 1 |
| 11 | Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke显示文摘 | Vogelgesang A Grunwald U Langner S | 2008 | Stroke2008，39，1： | 1 |
| 12 | Analysis of lympho- cyte subsets in patients with stroke and their influence on infection after stroke 显示文摘 | Vogelgesang A Grunwald U Langner S | 2008 | Stroke2008，39，1： | 1 |
| 13 | An enzyme-linked immunosorbent assay for the quantification of solubilized CD14 in biological fluids 显示文摘 | Grunwald U Krtiger C Westeann J | 1992 | J Immunol Methods1992，155，2： | 1 |
| 14 | Overlapping ex- pression patterns and differential transcript levels of phosphate transporter genes in arbuscular mycorrhizal, Pi-fertilised and phytohormone-treated Medicago truncatula roots显示文摘 | GRUNWALD U GUO W FISCHER K | 2009 | Planta2009，229，5： | 1 |
| 15 | Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke 显示文摘 | Vogelgesang A Grunwald U Langner S | 2008 | Stroke2008，39，11： | 1 |
| 16 | Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke显示文摘 | Vogelgesang A Grunwald U Langner S | 2008 | Stroke2008，39，： | 1 |
| 17 | Overlap- ping expression patterns and differential transcript levels of phosphate transporter genes in arhuscular mycorrhizal, Pi-fertilised and phytohormone- treated Medicago truncotulu roots 显示文摘 | Grunwald U Guo W B Fischer K | 2009 | Planta2009，229，： | 1 |
| 18 | Isolation and subunit composition of the 20S proteasome of Giardia lamblia显示文摘 | EMMERLICH V SANTARIUS U BAKKERGRUNWALD T | 1999 | Mol Biochem Parasitol1999，100，13： | 1 |
| 19 | Monocyte can phagocytose gram-negative bacteria by a CD14^- depedent mechanism 显示文摘 | Grunwald U Fan XL Jace RS | 1996 | J Immunol1996，157，9： | 1 |
| 20 | Fluorine-18 fluorodeoxyglucose positron emission tomography in thyroid cancer:results of a multicentre study显示文摘 | Grunwald F Kalicke T Feine U | 1999 | Eur J Nucl Med1999，26，12： | 1 |
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