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| 1 | Iron metabolism imbalance at the time of listing increases overall and infectious mortality after liver transplantation显示文摘BACKGROUND Liver transplantation(LT)is the best treatment for patients with liver cancer or end stage cirrhosis,but it is still associated with a significant mortality.Therefore identifying factors associated with mortality could help improve patient management.The impact of iron metabolism,which could be a relevant therapeutic target,yield discrepant results in this setting.Previous studies suggest that increased serum ferritin is associated with higher mortality.Surprisingly iron deficiency which is a well described risk factor in critically ill patients has not been considered.AIM To assess the impact of pre-transplant iron metabolism parameters on posttransplant survival.METHODS From 2001 to 2011,553 patients who underwent LT with iron metabolism parameters available at LT evaluation were included.Data were prospectively recorded at the time of evaluation and at the time of LT regarding donor and recipient.Serum ferritin(SF)and transferrin saturation(TS)were studied as continuous and categorical variable.Cox regression analysis was used to determine mortality risks factors.Follow-up data were obtained from the local and national database regarding causes of death.RESULTS At the end of a 95-mo median follow-up,196 patients were dead,38 of them because of infections.In multivariate analysis,overall mortality was significantly associated with TS>75%[HR:1.73(1.14;2.63)],SF<100μg/L[HR:1.62(1.12;2.35)],hepatocellular carcinoma[HR:1.58(1.15;2.26)],estimated glomerular filtration rate(CKD EPI Cystatin C)[HR:0.99(0.98;0.99)],and packed red blood cell transfusion[HR:1.05(1.03;1.08)].Kaplan Meier curves show that patients with low SF(<100μg/L)or high SF(>400μg/L)have lower survival rates at 36 mo than patients with normal SF(P=0.008 and P=0.016 respectively).Patients with TS higher than 75%had higher mortality at 12 mo(91.4%±1.4%vs 84.6%±3.1%,P=0.039).TS>75%was significantly associated with infection related death[HR:3.06(1.13;8.23)].CONCLUSION Our results show that iron metabolism imbalance(either deficiency or overload)is associated with post-transplant overall and infectious mortality.Impact of iron supplementation or depletion should be assessed in prospective study. | Elodie Fallet Michel Rayar Amandine Landrieux Christophe Camus Pauline Houssel-Debry Caroline Jezequel Ludivine Legros Thomas Uguen Martine Ropert-Bouchet Karim Boudjema Dominique Guyader Edouard Bardou-Jacquet | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 2 | ParasightR- F rapid manual diagnositic test of Plasmodium falciparum infection显示文摘 | Rabodonirina M De Pina JJ | 1995 | Bull WHO1995，73，5： | 1 |
| 3 | pre-mRNA splicing signature that progression in colorectal A gene expression and marks the adenoma- cancer显示文摘 | Pesson M Volant A Uguen A | 2014 | PLoS One2014，9，87： | 1 |
| 4 | Phage display as a tool for the directed evolution of enzymes显示文摘 | Uguen M Fastrez J | 2003 | Trends Biotechnol2003，21，9： | 1 |
| 5 | MicroRNA and targeted mRNA expression profiling analysis in human colorectal adenomas and adenocarcinomas显示文摘 | Gattolliat CH Uguen A Pesson M | 2015 | Eur J Cancer2015，51，3： | 1 |
| 6 | Phage display as a tool for the directed evolution of enzymes 显示文摘 | Fernandez-Gacio A Uguen M Fastrez J | 2003 | Trends Biotechnol2003，21，： | 1 |
| 7 | Phage display as a tool for the evolution of enzymes显示文摘 | Uguen M Fastrez J | 2003 | Trends in Biotechnology2003，21，： | 1 |
| 8 | Viability of Cryptosporidium parvum oocysts in natural waters 显示文摘 | Brasseur P Uguen C Moreno-Sabater A | 1998 | Folia Parasitol1998，45，2： | 1 |
| 9 | Phage display as a tool for the directed evolution of enzymes显示文摘 | Uguen M Fastrez J | 2003 | Trends Biotechnol2003，21，： | 1 |
| 10 | Influenceof osmolarity and the presence of anosmoprotectant on Lactococcus lactis growth andbacteriocin production显示文摘 | Uguen P Hamelin J Le Pennec JP | 1999 | Applied andEnvironmental Microbiology1999，65，1： | 1 |
| 11 | Phage display as a tool for the directed evolution of enzymes显示文摘 | Femandez-Gacio A Uguen M Fastrez J | 2003 | Trends in biotechnology2003，21，9： | 1 |
| 12 | Nutrient fluxes in rainfall,throughfall and stem-flow in tree-based land use systems and spontane oustree vegetation of central Amazonia显示文摘 | Elias E A Uguen K | 2001 | Agriculture Ecosystems and Environment2001，87，： | 1 |
| 13 | Phage display as a tool for the directed evolution of enzymes 显示文摘 | FERNANDEZ-GACIO A UGUEN M FASTREZ J | 2003 | Trends Bioteclmol2003，21，9： | 1 |
| 14 | Fine needle aspiration cytology of ALK negative T-cell anaplastic large-celllymphoma associated with breast implant显示文摘 | Talagas M Charles-Petillon F Uguen A | 2013 | ActaCytol2013，57，： | 1 |
| 15 | VEGFR1 andNRP1 endothelial expressions predict distant relapse af- ter radical prostatectomy in clinically localized prostate cancer显示文摘 | Talagas M Uguen A Garlantezec R | 2013 | Anticancer Res2013，33，5： | 1 |
| 16 | VEGFRI and NRPI endothelial expressions predict distant relapse after radical prostatectomy in clinically localized prostate cancer 显示文摘 | TALAGAS M UGUEN A GARLANTEZEC R | 2013 | Anticancer Res2013，33，5： | 1 |
| 17 | Nutrient fluxes in rain-fall,through-fall and stem-flow in tree-based land use systems and spontaneoustree vegetation of central Amazonia显示文摘 | Schroth G M Elias K Uguen R | 2001 | Agriculture Ecosystems and Environment2001，87，： | 1 |
| 18 | Phage display as a tool for the directed evolution of enzymes显示文摘 | Fernandez-Gacio A Uguen M Fastrez J | 2003 | Trends in Biotechnology2003，21，9： | 1 |
| 19 | 3'- Box- dependent processing of human pre U1 snRNA requires a combination of RNA and protein co-factors显示文摘 | Uguen P Murphy S | 2004 | Nucleic Acids Research2004，32，： | 1 |
| 20 | Phage display as a tool for the directed evolution of enzymes显示文摘 | Uguen M Fastrez J | 2003 | Trends Biotechnol2003，21，： | 1 |
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