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| 1 | Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis显示文摘AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 83 patients with suspected NAFLD and 49 healthy volunteers were investigated. Patients with suspected NAFLD were classified according to their liver histology into four groups: definitive NASH (n = 45), borderline NASH (n = 24), simple fatty liver (n = 9), and normal tissue (n = 5). Serum levels of caspase-3 generated cytokeratin-18 fragments (M30-antigen) and total cytokeratin-18 (M65-antigen) were determined by ELISA. RESULTS: Levels of M30-antigen and M65-antigen were significantly higher in patients with definitive NASH compared to the other groups. An abnormal value (> 121.60 IU/L) of M30-antigen yielded a 60.0% sensitivity and a 97.4% specificity for the diagnosis of NASH. Sensitivity and specificity of an abnormal M65-antigen level (> 243.82 IU/L) for the diagnosis of NASH were 68.9% and 81.6%, respectively. Among patients with NAFLD, M30-antigen and M65-antigen levels distinguished between advanced fibrosis and early-stage fibrosis with a sensitivity of 64.7% and 70.6%, and a specificity of 77.3% and 71.2%, respectively. CONCLUSION: Serum levels of M30-antigen and M65-antigen may be of clinical usefulness to identify patients with NASH. Further studies are mandatory to better assess the role of these apoptonecrotic biomarkers in NAFLD pathophysiology. | Yusuf Yilmaz Enver Dolar Engin Ulukaya Semra Akgoz Murat Keskin Murat Kiyici Sibel Aker Arzu Yilmaztepe Selim Gurel Macit Gulten Selim Giray Nak | 2007 | World Journal of Gastroenterology2007，13，6： | 19 |
| 2 | Clinical significance of activity of ALT enzyme in patients with hepatitis C virus显示文摘AIM: To investigate serum alanine aminotransferase (ALT) levels in relation to the clinical,biochemical,ultrasonographic and histological characteristics of patients with hepatitis C virus. METHODS: Duration of disease,HCV-RNA,liver steatosis,and the hepatitis activity index (HAI) were correlated with serum ALT in 36 patients with HCV. ALT values were also investigated in 16 control subjects without any liver diseases. RESULTS: In bivariate analyses,ALT levels correlated with duration of HCV infection (P < 0.01),HCV-RNA (P < 0.05),and the HAI (P < 0.01). Among the components of the HAI,ALT concentrations were significantly associated with periportal bridging/necrosis (P < 0.01) and fibrosis (P < 0.05). In multivariate analysis,periportal bridging/ necrosis (β = 0.508; P < 0.01),duration of HCV infection (β = 0.413; P < 0.01),and HCV-RNA (β = 0.253; P < 0.05) were independently associated with ALT activity. The normal ALT activity for men and women was < 23 IU/L and < 22 IU/L,respectively. CONCLUSION: In patients with HCV,alterations in the liver tissue as reflected by ALT elevation are mainly associated with periportal bridging/necrosis,viral load and duration of disease. A cut-off value < 23 IU/L distinguished with high diagnostic accuracy healthy controls from patients with HCV. | Onder Akkaya Murat Kiyici Yusuf Yilmaz Engin Ulukaya Omer Yerci | 2007 | World Journal of Gastroenterology2007，13，41： | 2 |
| 3 | Mobile phone exposure does not induce apoptosis on spermatogenesis in rats显示文摘 | Dasdag S Akdag MZ Ulukaya E | 2008 | Arch Med Res2008，39，1： | 1 |
| 4 | Mobile phone exposure does not induce apoptosis on spermatogenesis in rats 显示文摘 | Dasdag S Akdag MZ Ulukaya E | 2008 | Arch Med Res2008，39，： | 1 |
| 5 | Higher serum nitrate levels are associated with poor survival in lung cancer patients显示文摘 | Colakogullari M Ulukaya E Yilmaztepe A | 2006 | Clin Biochem2006，39，9： | 1 |
| 6 | Causes of postreperfusion syndrome in living or cadaveric donor liver transplantations显示文摘 | Ayanoglu HO Ulukayas S Tokat Y | 2003 | Transplant Proc2003，35，4： | 1 |
| 7 | The involvement of IL-10, IL-6, IFN-gamma, TNF- alpha and TGF-beta gene polymorphisms among Turkish lung cancer patients显示文摘 | Colakogullari M Ulukaya E Aymak F | 2008 | Cell Biochem Funct2008，26，： | 1 |
| 8 | Cytokine gene polymor- phism and postreperfusion syndrome during or thotopic liver transplantation 显示文摘 | Ulukaya S Basturk B Kilic M | 2008 | Transplantation Proceedings2008，，40： | 1 |
| 9 | Mobile phone exposure does not induce apoptosis on spermatogenesis in rats显示文摘 | Dasdag S Akdag MZ Ulukaya E | 2008 | Arch Med Res2008，39，1： | 1 |
| 10 | The involvement of IL - 10, IL - 6, IFN - gamm a, TNF - alpha and TGF- beta gene polymorphisms among Turkish lung cancer pa- tients 显示文摘 | Colakogullari M Ulukaya E Yilmaztepe Oral A | 2008 | Cell Biochem Funct2008，26，3： | 1 |
| 11 | Mobile phoneexposure does not induce apoptosis on spermatogenesis inrats 显示文摘 | Dasdag S Akdag M Z Ulukaya E | 2008 | Arch Med Res2008，39，1： | 1 |
| 12 | The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival显示文摘 | Ulukaya E Yilmaztepe A Akgoz S | 2007 | Lung Cancer2007，56，3： | 1 |
| 13 | Response to neoadjuvant chemotherapy in breast cancer could be predictable by measuring a novel serum apoptosis product,caspase-cleaved cytokeratin 18:a prospective pilot study显示文摘 | Demiray M Ulukaya EE Arslan M | 2006 | Cancer Invest2006，24，7： | 1 |
| 14 | The involvement of IL 10,IL-6,IFN- gamma,TNF alpha and TGF-beta gene polymorphisms among Turkish lung cancer patients显示文摘 | Colakogullari M Ulukaya E Yilmaztepe Oral A Aymak F Basturk B Ursavas A | 2008 | Cell Biochcm Funct2008，96，： | 1 |
| 15 | Mobile phone exposure does not induce apoptosis on spermatogenesis in rats 显示文摘 | Dasdag S Akdag MZ Ulukaya E | 2008 | Arch Med Res2008，39，1： | 1 |
| 16 | Modulation of protein ex- pression levels and DNA methylation status of breast cancer metastasis genes by anthraeycline-based chemotherapy and the demethylating a- gent decitabine 显示文摘 | Ari F Napieralski R Ulukaya E | 2011 | Cell Biochemistry and Function2011，29，8： | 1 |
| 17 | The MIT assay yields a relatively lower result of growth inhibition than the ATP assay depending on the chemotherapeutic drugs tested 显示文摘 | Ulukaya E Ozdikicioglu F Oral A Y | 2008 | Toxicology in Vitro2008，22，1： | 1 |
| 18 | Causes of postreperfusion Syndrome in living or cadaveric donor liver transplantations显示文摘 | Ayanoglu HO Ulukaya S Tokat Y | 2003 | Transplant Proc2003，35，： | 1 |
| 19 | Cytokine gene polymorphism and early graft rejection in liver transplant recipients显示文摘 | KARASU Z ULUKAYA S AYANOGLU HO et aL | 2004 | Transplant Proc2004，36，9： | 1 |
| 20 | Maxillary protraction appliance effect on the size of the upper airway passage显示文摘 | Oktay H Ulukaya E | 2008 | Angle Orthod2008，78，2： | 1 |
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