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| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 3 | International experts consensus guidelines on robotic liver resection in 2023显示文摘The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still exist.Based on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical practice.The guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation group.According to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were generated.Among them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM results.This international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future. | Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau | 2023 | World Journal of Gastroenterology2023，29，32： | 2 |
| 4 | Price Competition under Stockpiling and Flexible Con- sumption显示文摘 | BELL D R IYER G PADMANABHAN V | 2002 | Journal of Marketing Research2002，39，8： | 1 |
| 5 | Knock- down of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence显示文摘 | ALSAYEGH K N GADEPALLI V S IYER S | 2015 | PLoS One2015，10，01： | 1 |
| 6 | Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1显示文摘 | Forsythe J A Jiang B H Iyer N V | 1996 | Mol Cell Biol1996，16，： | 1 |
| 7 | Exploring the metabolic and genetic control of gene expression on a genomic scale显示文摘 | DeRisi J Iyer V R Brown P O | 1997 | Science1997，278，： | 1 |
| 8 | Some properties of noether charge and a proposal for dynamical black hole entropy显示文摘 | Iyer V Wald R M | 1995 | Phys Rev1995，，52： | 1 |
| 9 | Quick response in manufacturer retailer channels显示文摘 | Iyer A V Bergen M E | | 0，，04： | 1 |
| 10 | Orexins/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress显示文摘 | Heydendael W Sharma K Iyer V | 2011 | Endocrinology2011，52，12： | 1 |
| 11 | Quick Response in Manufacturer-Retailer Channels 显示文摘 | IYER A V BERGEN M E | 1997 | Management Sci- ence1997，43，4： | 1 |
| 12 | Prevalence, clinical and bio- chemical profile of subclinical hypothyroidism in normal population in Mumbai 显示文摘 | Deshmukh V Behl A Iyer V | 2013 | Indian J Endocrinol Metab2013，17，3： | 1 |
| 13 | A postponement model for demand management显示文摘 | Iyer A Deshpande V Wu Z | | 0，，08： | 1 |
| 14 | MRI,CT and PET/CT for ovarian cancer detection and adnexal lesion characterization显示文摘 | Iyer V R Lee S I | 2010 | AJR2010，194，2： | 1 |
| 15 | Alpha 3betal integrin regulates MMP-9 mRNA stability in immortalized keratinocytes: a novel mechanism of integrin-mediated MMP gene expression 显示文摘 | IYER V PUMIGLIA K DIPERSIO C M | 2005 | J Cell Sci2005，118，6： | 1 |
| 16 | Experimental and theoretical verification of focusing in a large, periodically loaded transmission line negative refractive index metamaterial显示文摘 | IYER A K KREMER P C ELEFTHERIADES G V | 2003 | Opt Express2003，11，7： | 1 |
| 17 | Equilibrium swelling behavior of thermally responsive metal affinity hydrogels, Part I: Compositional effects 显示文摘 | IYER G TILLEKERATNE L M V COLEMAN M R NADARAJAH A | 2008 | Polymer2008，49，17： | 1 |
| 18 | 查看详情显示文摘 | Vanka K Singh G Iyer D Gupta V K | | 0，，37： | 1 |
| 19 | Activation of vascular endothelial growth gene transcription by hypoxia - inducible factor - 1 α 显示文摘 | Forsythe J A Jiang B H Iyer N V | 1996 | Mol Cell Biol1996，16，： | 1 |
| 20 | Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1显示文摘 | Forsythe J A Jiang B H Iyer N V | 1996 | Mol Cell Biol1996，16，： | 1 |
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