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| 1 | Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease显示文摘BACKGROUND In non-alcoholic fatty liver disease(NAFLD), a high-fat or high-fructose diet increases intestinal permeability and promotes derangement of the gut-liver axis.We hypothesize that, diet could be able to modulate intestinal permeability in patients with NAFLD.AIM To detect diet-induced modification of intestinal permeability in patients with NAFLD undergoing a Mediterranean diet or a low-fat diet.METHODS The current study was a dietary intervention for non-diabetic, patients with biopsy-verified NAFLD and increased transaminases. A crossover design was employed: participants underwent 16 weeks of Mediterranean diet, 16 wk of free wash-out, and 16 weeks of low-fat diet. Both diets were hypocaloric and no consumption of supplements was allowed. All patients were followed bimonthly by a dietitian. Evaluations of clinical and metabolic parameters were completed at baseline and at the end of each dietary period. Intestinal permeability was assessed by chromium-51 ethylene diamine tetraacetate excretion testing(51 CrEDTA).RESULTS Twenty Caucasian patients, 90% male, median age 43 years, body mass index(BMI) 30.9, with biopsy-verified NAFLD were enrolled. At the end of 16 weeks of a Mediterranean diet, a significant reduction in mean body weight(-5.3 ± 4.1 kg,P = 0.003), mean waist circumference(-7.9 ± 4.9 cm, P = 0.001), and mean transaminase levels [alanine aminotransferase(ALT)-28.3 ± 11.9 IU/L, P =0.0001; aspartate aminotransferase(AST)-6.4 ± 56.3 IU/L, P = 0.01] were observed. These benefits were maintained after 16 wk of wash-out and also after16 wk of low-fat diet, without further improvements. Fourteen of the 20 patients had intestinal permeability alteration at baseline(mean percentage retention of51 Cr-EDTA = 5.4%), but no significant changes in intestinal permeability were observed at the end of the 16 wk of the Mediterranean diet or 16 wk of the low-fat diet.CONCLUSION Mediterranean diet is an effective strategy for treating overweight, visceral obesity and serum transaminase in patients with NAFLD. If the Mediterranean diet can improve intestinal permeability in patients with NAFLD, it deserves further investigation. | Marco Biolato Fiorella Manca Giuseppe Marrone Consuelo Cefalo Simona Racco Giacinto A Miggiano Venanzio Valenza Antonio Gasbarrini Luca Miele Antonio Grieco | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 2 | The effect of a liquid CTBN rubber modifier on the thermo-kinetic parameters of an epoxy resin during a pultrusion process显示文摘 | L Calabrese A Valenza | 2003 | Composites Science and Technology2003，63，6： | 1 |
| 3 | Glass-basah/epoxy hybrid composites for marine applications显示文摘 | Fiore V Di Bella G Valenza A | 2011 | Materials & Design2011，32，4： | 1 |
| 4 | Quantitative PCR and RT-PCR in virology 显示文摘 | Menzo S Bagnarelli P Manzin A Valenza A Varaldo PE | 1993 | PCR Methods Appl1993，2，3： | 1 |
| 5 | Transcatheter arterial ehemoembolisation for hepatocellular carcinoma in cirrhosis: sur- vival rate and prognostic faetors 显示文摘 | Olivo M Valenza F Buccellato A | 2010 | Dig Liver Dis2010，42，7： | 1 |
| 6 | Revealing real-time emotional responses: a personalized assessmentbased on heartbeat dynamics 显示文摘 | Valenza G Citi L Lanata A | 2014 | Sci Rep2014，4，： | 1 |
| 7 | Oxygen influenceon ceramics wettability by liquid metals: Ag/ α-Al2 O3-Experiments and modeling显示文摘 | Muolo L M Valenza F Passerone A | 2008 | Materials Science and EngineeringA2008，495，： | 1 |
| 8 | Influence of tile irradiation parameters on the molecular modifications of an iso-tactic polypropylene gamma irradiated under vacuum显示文摘 | G Spadaro A Valenza | 2000 | Polymer degradation and stability2000，67，3： | 1 |
| 9 | Characteriza- tion of ultra high molecular weight polyethylene (UHM- WPE) modified by ion implantation显示文摘 | Valenza A Visco A M Torrisi L | 2004 | Polymer2004，45，： | 1 |
| 10 | Characterization of ultra-high-molecular weight polyethylene (UHMWPE) modified by ion implantation显示文摘 | Valenza A | 2004 | Polymer2004，45，5： | 1 |
| 11 | Inhabition of return in newborn infants显示文摘 | VALENZA E SIMION F UMILT A C | 1994 | Infant Behavioral Development1994，，17： | 1 |
| 12 | Abdomino-thoracic transmission during ACS: facts and figures显示文摘 | Wauters J Wilmer A Valenza F | 2007 | Acta Clin Belg Suppl2007，，1： | 1 |
| 13 | Influence of the irradiation parameters on the molecular modifications of an isotactic polypropylene gamma - irradiated under vacuum 显示文摘 | Spadaro G Valenza A | 2000 | Polymer Degradation & Stability2000，67，3： | 1 |
| 14 | The effect of a liquid CTBN rubber modifier on the thermo-kinetic parameters of an epoxy resin during a pultrusion process显示文摘 | Calabrese L Valenza A | 2003 | Compos Sci Techn2003，63，6： | 1 |
| 15 | Influence of groundwater on the degradation of irrigated soils in a semi-arid region, the inner delta of the Nige River, Mali显示文摘 | Valenza A Grillot J C Dazy J | 2000 | Hydrogeology Journal2000，8，： | 1 |
| 16 | Effect of CTBN rubber inclusions on the curing kinetic of DGEBA-DGEBF epoxy resin显示文摘 | Calabrese L Valenza A | 2003 | Eur Polyrn J2003，39，7： | 1 |
| 17 | Ghrelin does not in- fluence gastric emptying in obese subjects显示文摘 | Valera Mora M E Scarfone A Valenza V | 2005 | Obes Res2005，13，： | 1 |
| 18 | Effect of UD carbon on the spe- cific mechanical properties of glass mat composites for marine applications显示文摘 | Valenza A Fiore V Di Bella G | 2010 | Journal of Composite Materials2010，44，11： | 1 |
| 19 | Determination of volatile fatty acids in the hot springs of ulcano显示文摘 | AMEND J P AMEND A C VALENZA M | 1998 | Org Geochem1998，28，11： | 1 |
| 20 | Relationships between mechanical properties and structure for blends of nylon-6 witha liquid crystal polymer显示文摘 | La Mantia F P Saiu M Valenza A | 1990 | Europ Polym J1990，26，3： | 1 |
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