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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster 显示文摘 | Xu S Witmer PD Lumayag S Kovacs B Valle D | 2007 | J Biol Chem2007，282，25： | 1 |
| 3 | Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae显示文摘 | Chassaing Benoit Rolhion Nathalie de Vallée Amélie Salim Sa’ad Y Prorok-Hamon Maelle Neut Christel Campbell Batty J S?derholm Johan D Hugot Jean-Pierre Colombel Jean-Frédéric Darfeuille-Michaud Arlette | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 4 | MicroRNA (miRNA) transeriptome of mouse retina and identification of a sensory organ-specific miRNA eluster显示文摘 | Xu S Witmer P D Lumayag S Kovacs B Valle D | 2007 | J Biol Chem2007，282，25： | 1 |
| 5 | Does the consumption of caloric and non-caloric beverages with a meal affect energy intake显示文摘 | DELLA VALLE D M ROE L S ROLLS B J | 2005 | Appetite2005，44，： | 1 |
| 6 | Application of a potentiometric electronic tongue as a classification tool in food analysis显示文摘 | Gallardo J Alegret S Valle M D | 2005 | Talanta2005，66，： | 1 |
| 7 | Myostatin expression during development and chronic stress in zebrafish (Danio rerio) 显示文摘 | Vianello S Brazzoduro L Valle L D | 2003 | Journal of Endocrinology2003，176，1： | 1 |
| 8 | ParticleSwarm Optimization:Basic Concepts,Variants and Applica-tions in Power Systems显示文摘 | Valle Y d Venayagamoorthy G K Mohagheghi S | 2008 | IEEE Transactions on Evolution-ary Computation2008，12，2： | 1 |
| 9 | Hyperspec-tral remote sensing of plant biochemistry using Bayesian model averaging with variable and band selection 显示文摘 | Zhao Kaiguang Valle D Popescu S | 2013 | Remote Sensing of Environment2013，，132： | 1 |
| 10 | Synthesis,characterization and electrical properties of poly(2,5-,2,3-and 3,5-dichloroaniline)s PartⅡ:Copolymer with aniline显示文摘 | Díaz F Sánchez C Valle M | 2001 | Synth Met2001，118，： | 1 |
| 11 | Pseudacteon decapita- ting flies (Diptera: Phoridae): Are they potential vectors ofthe fire ant pathogens Kneallhazia (--Thelohania) solenopsae ( Microsporidia: Thelohaniidae ) and Vairimorpha invictae (Microsporidia: Burenellidae)?显示文摘 | Oi D H Porter S D Valles S M | 2009 | Biological Control2009，48，3： | 1 |
| 12 | The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla显示文摘 | JAILLON O AURY J M NOEL B POLICRITI A CLEPET C CASAGRANDE A CHOISNE N AUBOURG S VITULO N JU- BIN C VEZZI A LEGEAI F HUGUENEY P DASILVA C HORNER D MICA E JUBLOT D POULAIN J BRUYERE C BILLAULT A SEGURENS B GOUYVENOUX M UGARTE E CATTONARO F ANTHOUARD V VICO V DEL FABBRO C ALAUX M DI GASPERO G DUMAS V FELICE N PAILLARD S JUMAN I MOROLDO M SCALABRIN S CANAGUIER A LE CLAINCHE I MALACRIDA G DURAND E PESOLE G LAUCOU V CHATELET P MERDINOGLU D DELLEDONNE M PEZZOTYI M LECHARNY A SCARPELLI C ARTIGUE- NAVE F PE M E VALLE G MORGANTE M CABOCHE M ADAM-BLONDON A F WEISSENBACH J QUETIER F WINCKER P | 2007 | Nature2007，449，27： | 1 |
| 13 | Concurrent engineering performance: Incremental versus radical innovation显示文摘 | Valle S Vazquez-Bustelo D | 2009 | International Journal of Production Economics2009，119，1： | 1 |
| 14 | Influence of the variation between static and kinetic friction on stick-slip instability显示文摘 | Capone G D'Agostino V Valle S D | 1993 | Wear1993，161，12： | 1 |
| 15 | Prospective randomized trial of 3 antiseptic solutions for prevention of catheter colonization in an intensive care unit for adult patients显示文摘 | Vallés J Fernández I Alcaraz D | 2008 | Infect Control Hosp Epidemiol2008，29，9： | 1 |
| 16 | Synthesis and characterization and electrical properties of dinalogenated polyanilines显示文摘 | Díaz F Sánchez C Valle M | 1998 | Synth Met1998，，92： | 1 |
| 17 | Semantically- grounded Construction of Centroids for Datasets with Textual Attributes 显示文摘 | Mart'Tnez S Valls A S6nehez D | 2012 | Knowledge-Based Systems2012，35，： | 1 |
| 18 | Compact high gain erbiumytterbium doped waveguide amplifier fabricated by Ag-Na ion exchange 显示文摘 | Valle G D Taccheo S Sorbello G | 2006 | Electron Lett2006，42，11： | 1 |
| 19 | A 7-year study of severe hospital-acquired pneumonia requiring ICU admission显示文摘 | Vallés J Mesalles E Mariscal D | | 0，，11： | 1 |
| 20 | Inhospital complications and mortality of unilateral, bilateral,and revision TKA:based on an estimate of 4159661 diseharges显示文摘 | Memtsoudis S G Valle G D | 2008 | Clin Orthop Relat Res2008，466，： | 1 |
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