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| 1 | 食物过敏的定义、流行性、诊断及治疗显示文摘食物过敏是异质性群体相关疾病,会通过一种或多种方式对多个器官造成影响。其反应的严重程度可从轻度的局部反应到全身性的过敏反应。从机制上来看,食物过敏是Th2细胞驱动的免疫紊乱疾病,食物特异性IgE是这种速发型不良反应的基础。过敏的部位和症状并不一定相同。食物过敏常会与自身免疫性(如乳糜泻)和非免疫性(如乳糖不耐受)的其他食物不良反应相混淆。为了正确诊断食物过敏,需要详细了解患者病史,检测特异性IgE,并进行经口激发试验来确诊。一些辅助因素(如运动、药物和酒精)有助于诱发食物过敏,会进一步增加诊断的复杂性。以食物提取物为基础的诊断试验并不能反映症状的严重程度,而检测单个食物致敏原IgE的新一代分子诊断技术,则能够为临床医生和患者提供可靠的症状严重程度依据。分子诊断还有助于确定食物过敏是直接源于对食物的暴露还是间接源于花粉过敏(交叉反应)。流行病学调查表明,桃过敏在欧洲主要是源于对桃的食用,而在中国则是源于对艾蒿花粉的初级致敏。但这两种情况都是由来自同一家族的致敏原分子介导的。流行病学调查深入揭示了食物过敏的病因、流行性及其所包含的风险因素,为预防食物过敏提供了循证策略。过去的十年中,食物过敏在发达国家盛行。经济发展和城市化进程都被认为会导致食物过敏流行性的增加,而且饮食习惯不同,过敏的食物也不同。目前,分子变态反应学和生物技术正在开发安全的免疫治疗方法,有望能够减轻日益加重的食物过敏负担。一种使用低致敏性突变重组分子的免疫疗法已经开始进行第一阶段临床试验的评估。食物致敏原名单的不断完善为转基因食品致敏性的评估提供了坚实基础。 | Ronald van Ree Lars K. Poulsen Gary WK Wong Barbara K. Ballmer-Weber 高中山 贾旭东 | 2015 | 中华预防医学杂志2015，49，1： | 28 |
| 2 | Anaphylaxis and generalized urticaria from eating Chinese bayberry fruit显示文摘Chinese bayberry Myrica rubra is a very popular fruit in southeastern China.In spite of its wide consumption,no allergies to this fruit have been reported previously.Here we report on a 40-year-old woman suffering from anaphylaxis to Chinese bayberry fruit.Prick-prick skin tests revealed strong reactions to fresh Chinese bayberry fruits as well as to peach,and weaker reactions to some other fruits including apple,melon,and banana.ImmunoCAP analysis revealed identical titers of specific IgE(4.3 kU A /L) to peach extract and its lipid transfer protein(LTP,rPru p 3),which was confirmed by detection of a 9 kD band following immunoblotting.Immunoblot analysis with Chinese bayberry extract gave bands of 22,45,and 90 kD,but no 9 kD band was recognized.There was also no evidence of LTP recognition for loquat(36 kD) or melon(24 kD).This first report of a severe allergic reaction to Chinese bayberry fruit in a patient with LTP-mediated peach allergy indicates that other as yet unidentified non-pollen related fruit allergens are involved in this new severe fruit allergy. | Hui-ying WANG Zhong-shan GAO Zhao-wei YANG Jing-xin SHAO Xiu-zhen ZHAO Yu DAI Ronald VAN REE | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，10： | 3 |
| 3 | Latest Advances in High-Voltage and High-Energy-Density Aqueous Rechargeable Batteries显示文摘Aqueous rechargeable batteries(ARBs)have become a lively research theme due to their advantages of low cost,safety,environmental friendliness,and easy manufacturing.However,since its inception,the aqueous solution energy storage sys-tem has always faced some problems,which hinders its development,such as the narrow electrochemical stability window of water,poor percolation of electrode materials,and low energy density.In recent years,to overcome the shortcomings of the aqueous solution-based energy storage system,some very pioneering work has been done,which also provides a great inspiration for further research and development of future high-performance aqueous energy storage systems.In this paper,the latest advances in various ARBs with high voltage and high energy density are reviewed.These include aqueous rechargeable lithium,sodium,potassium,ammonium,zinc,magnesium,calcium,and aluminum batteries.Further chal-lenges are pointed out. | Xinhai Yuan Fuxiang Ma Linqing Zuo Jing Wang Nengfei Yu Yuhui Chen Yusong Zhu Qinghong Huang Rudolf Holze Yuping Wu Teunis van Ree | 2021 | Electrochemical Energy Reviews2021，4，1： | 2 |
| 4 | Atypical xanthomatosis in apolipoprotein E - deficient mice after cholesterol feeding显示文摘 | van Ree JH Gijbels MJJ van den Broek WJAA | 1995 | Atherosclerosis1995，112，2： | 1 |
| 5 | Two-year statin therapy does not alter the progression of intima-media thickness in patients with type 2 diabetes without manifest cardiovascular disease显示文摘 | Beishuizen ED van de Ree MA Jukema JW el al | 2004 | Diabetes Care2004，27，12： | 1 |
| 6 | Beta-glucan in- corporated into a fruit drink effectively lowers serum LDL- cholesterol concentrations显示文摘 | Naumann E van Rees AB Onning G | 2006 | Am J Clin Nutr2006，83，3： | 1 |
| 7 | Strong decrease of high sensitivity C- reactive protein with high-dose atorvastation in patients with type 2 diabetes mellitus显示文摘 | Van de Ree MA Huisman MV Princen HM | 2003 | Atheroscler2003，116，1： | 1 |
| 8 | Cross-reactivity of IgE antibodies to allergens显示文摘 | Aalberse RC Akkerdaas J Van Ree R | 2001 | Allergy2001，56，6： | 1 |
| 9 | Allergy, parasites, and the hygiene hypothesis显示文摘 | Yazdanbakhsh M Kremsner PG van Ree R | 2002 | Science2002，19，： | 1 |
| 10 | A review of fine root dynamics in Populus plantations显示文摘 | Block RMA van Rees KCJ Knight JD | | 0，，： | 1 |
| 11 | Expression of cyclooxygenase - 2 in dysplasia of the stomach and in intestinal- type gastric adenocarcinoma 显示文摘 | Saukkonen K Nieminen O van Rees B | 2001 | Clin Cancer Res2001，7，： | 1 |
| 12 | Long-term treatment of intestinal helminths increases mite skin-test reactivity in gabonese schoolchildren显示文摘 | Van den Biggelaar AH Rodrigues LC van Ree R | 2004 | J Infect Dis2004，189，： | 1 |
| 13 | Epstein-Barr virus in gastric carcinomas and gastric stump carcinomas: a late event in gastric carcinogenesis 显示文摘 | Zur Hausen A van Rees BP van Beck J | 2004 | J Clin Pathol2004，57，5： | 1 |
| 14 | High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients显示文摘 | van Tirmneren MM Vaidya VS van Ree RM | 2007 | Transplantation2007，84，12： | 1 |
| 15 | Overexpression of the E2 ubiquitin-conjugating enzyme UbcHlO causes chromosome missegregation and tumor formation显示文摘 | Van Ree JH Jeganathan KB Malureanu L | 2010 | J Cell Biol2010，188，1： | 1 |
| 16 | Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Thl and Th2 cytokines 显示文摘 | Dieleman LA Palmen MJ Akol H Bloemena E Pena AS Meuwissen SG Van Rees EP | 1998 | Clin Exp Immunol1998，114，： | 1 |
| 17 | Strong decrease of high sensitivity C-reactive protein with high-dose atorvastatin in patients with type 2 diabetes mellitus 显示文摘 | van de Ree MA Huisman MV Princen HMG | 2003 | Atherosclerosis2003，166，： | 1 |
| 18 | The use of D-dimer in specific clinical conditions : a narrative review显示文摘 | Bruinstroop E van de Ree MA Huisman MV | 2009 | Eur J Intern Med2009，20，5： | 1 |
| 19 | Measure- ment of IgE antibodies against purified grass pollen allergens (Lol p 1, 2, 3 and 5) during immunotherapy显示文摘 | Van Ree R Van Leeuwen WA Dieges PH etal | 1997 | Clin Exp Allergy1997，27，： | 1 |
| 20 | Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus 显示文摘 | Buskens CJ Van Rees BP Sivula A | 2002 | Gastroenterology2002，122，7： | 1 |
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