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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Determinants of the decision to submit market or limit orders on the ASX 显示文摘 | Verhoeven P Ching S Guan H | 2004 | Pacific-Basin Finance Journal2004，12，1： | 1 |
| 3 | Neuroimaging of autism 显示文摘 | Verhoeven JS De Cock P Lagae L | 2010 | Neuroradiology2010，52，1： | 1 |
| 4 | Dividend Initiations and Long-run IPO Performance 显示文摘 | How J C Ngo Y K’Verhoeven P | 2011 | Australian Journal of Management2011，36，2： | 1 |
| 5 | Decomposition of Carex and Sphagnum litter in two mesotrophic fens differing in dominant plant species 显示文摘 | Scheffer R A Van Logtestijn R S P Verhoeven J T A | 2001 | Oikos2001，92，1： | 1 |
| 6 | Microvessel quantification in primary colorectal carcinoma:an immunohistoc, hemical study 显示文摘 | Vermeulen P B Verhoeven D Fierens H | 1995 | Br J Cancer1995，71，2： | 1 |
| 7 | Neuroimaging of autism显示文摘 | Verhoeven JS De Cock P Lagae L | 2010 | Neuroradiology2010，52，11： | 1 |
| 8 | An antibiotic policing to prevent emergence of resistant bacilli 显示文摘 | DeMan P Verhoeven BAN Verbrugh HA | 2000 | Lancet2000，355，： | 1 |
| 9 | A compari- son of the effects of various spindle toxins onmetaphase arrest and formation of micronuclei in cell-suspension cultures of Nicotia plumbno- lia显示文摘 | Ramulu K S Verhoeven H A Dijkhuis P | 1990 | Planta1990，182，： | 1 |
| 10 | Fat tails and asymmetry in financial volatility models显示文摘 | Verhoeven P McAleer M | 2004 | Mathematics and Computers in Simulation2004，64，3： | 1 |
| 11 | All antimicrobial agent policy to prenvent emergence of re- sistanct bacilli显示文摘 | DE MAN P VERHOEVEN B A N VERBRUGH H A | 2000 | Lancet2000，355，： | 1 |
| 12 | An antibi- otic policy to prevent emergence of resistant bacilli显示文摘 | de Man P Verhoeven BA Verbrugh HA | 2000 | Lancet2000，355，9208： | 1 |
| 13 | Xanthan gum to tailor drug release of sustained-release ethyl-cellulose mini-matrices prepared via hot-melt extrusion:in vitro and in vivo evaluation显示文摘 | Verhoeven E Vervaet C Remon J P | 2006 | European Journal of Pharmaceutics and Biopharmaceutics2006，63，： | 1 |
| 14 | Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains显示文摘 | Johannes V Swinnen Paul P Van Veldhoven Leen Timmermans Ellen De Schrijver Koen Brusselmans Frank Vanderhoydonc Tine Van de Sande Hannelore Heemers Walter Heyns Guido Verhoeven | 2003 | Biochemical and Biophysical Research Communications2003，，4： | 1 |
| 15 | Secondary electron emission measurements on synthetic diamond films 显示文摘 | Hopman H Verhoeven I J Bachmann P K | 1999 | Diamond and Related Materials1999，，8： | 1 |
| 16 | Secondary electron emission measurements on synthetic diamond films显示文摘 | Hopman H J Verhoeven J Bachmann P K | 1999 | Diamond andRelated Materials1999，8，6： | 1 |
| 17 | A diastereospecific, non-racemic synthesis of a novel β- hydroxy-δ-lactone HMG-CoA reductase inhibitor显示文摘 | Sletzinger M Verhoeven T R Volante R P | 1985 | Tetrahedron lett1985，26，： | 1 |
| 18 | Corporate governance,accounting and finance:a review显示文摘 | Brown P Beekes W Verhoeven P | 2011 | Accounting&Finance2011，51，1： | 1 |
| 19 | The cerebellum : Its role in language and related cognitive and affective functions 显示文摘 | De Smet H J Paquier P Verhoeven J | 2013 | Brain Lang2013，127，： | 1 |
| 20 | Determination of the manning roughness coefficient influenced by vegetation in the river Aa and Biebrza river显示文摘 | DONCKER L TROCH P VERHOEVEN R | 2009 | Environmental Fluid Mechanics2009，9，5： | 1 |
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