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| 1 | Negundoside,an irridiod glycoside from leaves of Vitex negundo,protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride显示文摘AIM:To evaluate the protective effect of 2'-p-hydroxy benzoylmussaenosidic acid [negundoside(NG) ,against carbon tetrachloride(CCl4) -induced toxicity in HuH-7 cells. METHODS:CCl4 is a well characterized hepatotoxin,and inducer of cytochrome P450 2E1(CYP2E1) -mediated oxidative stress. In addition,lipid peroxidation and accumulation of intracellular calcium are important steps in the pathway involved in CCl4 toxicity. Liver cells(HuH-7) were treated with CCl4,and the mechanism of the cytoprotective effect of NG was assessed. Silymarin,a known hepatoprotective drug,was used as control. RESULTS:NG protected HuH-7 cells against CCl4 toxicity and loss of viability without modulating CYP2E1 activity. Prevention of CCl4 toxicity was associated with a reduction in oxidative damage as reflected by decreased generation of reactive oxygen species(ROS) ,a decrease in lipid peroxidation and accumulation of intracellular Ca2+ levels and maintenance of intracellular glutathione homeostasis. Decreased mitochondrial membranepotential(MMP) ,induction of caspases mediated DNA fragmentation and cell cycle arrest,as a result of CCl4 treatment,were also blocked by NG. The protection afforded by NG seemed to be mediated by activation of cyclic adenosine monophosphate(cAMP) synthesis and inhibition of phospholipases(cPLA2) . CONCLUSION:NG exerts a protective effect on CYP2E1-dependent CCl4 toxicity via inhibition of lipid peroxidation,followed by an improved intracellular calcium homeostasis and inhibition of Ca2+-dependent proteases. | Sheikh A Tasduq Peerzada J Kaiser Bishan D Gupta Vijay K Gupta Rakesh K Johri | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 2 | Deletion of TLR5 results in spontaneous colitis in miee显示文摘 | Vijay Kumar M Sanders C J Taylor R T | 2007 | J Clin Invest2007，117，12： | 1 |
| 3 | Metastatic gestational trophoblastic tumour presenting as spontaneous subcapsular renal haematoma显示文摘 | Vijay RK Kaduthodil M J Bottomley JR | 2008 | Br J Radiol2008，81，969： | 1 |
| 4 | A Structural Transformation in Bovine and Human Plasma Albumins in Alkaline Solution as Revealed by Rotatory Dispersion Studies显示文摘 | VIJAI K K FOSTER J F | 1963 | J Biol Chem1963，238，： | 1 |
| 5 | Application of a high-throughput HPLC-MS/MS assay to arabidopsis mutant screening; evidence that threonine aidolase plays a role in seed nutritional quality显示文摘 | Georg J Susan RN Vijay J | 2004 | The Plant Journal2004，39，： | 1 |
| 6 | Software implementation of online risk-based security assessment显示文摘 | Ni Ming Mccalley J D Vittal Vijay | 2003 | IEEE Trans on Power Systems2003，18，3： | 1 |
| 7 | Systemic inflam- mation and ammonia in hepatic encephalopathy 显示文摘 | Tranah T H Vijay G K Ryan J M | 2013 | Metab Brain Dis2013，28，1： | 1 |
| 8 | Modeling the survival of Escherichia coli O157 : H7, Listeria monocytogenes, and Salmolla Typhimurium during fermentation, drying, and storage of soudjouk -style fermented sausag 显示文摘 | Cheng AH Anna CS Vijay K J | 2009 | International Journal of Food Microbiology2009，129，3： | 1 |
| 9 | Novel L, adaptive control methodology for aerial refueling with guaranteed transient performance 显示文摘 | Wang J Vijay p Cao C | 2008 | Journal of Guidance Control and Dynamics2008，31，1： | 1 |
| 10 | A Conductive Ormosil Encapsulated with Ferrocene Conjugate and Multiwall Cabon Nanotubes for Biosensing Application显示文摘 | Vivek B K Vijay S T Huang X J | 2006 | Biomaterials2006，27，7： | 1 |
| 11 | 显示文摘 | Singh M Arora J S Vijay Y K | 2006 | Bull Mater Sei2006，29，1： | 1 |
| 12 | Exogenously Added Polyamines Recover Browning Tissues into Normal Callus Cultures and Improve Plant Regeneration in Pine显示文摘 | Tang W Ronald J N Vijay O | 2004 | Physiologic Planetarium2004，122，3： | 1 |
| 13 | Effects of Gene Deletion of the Tissue Inhibitor of the Matrix Metalloproteinase-type 1 (TIMP-1) on Left Ventricular Geometry and Function in Mice显示文摘 | Lisa Roten Shintaro Nemoto Janet Simsic Mytsi L Coker Vijay Rao Simona Baicu Gilberto Defreyte Paul J Soloway Michael R Zile Francis G Spinale | 2000 | Journal of Molecular and Cellular Cardiology2000，，1： | 1 |
| 14 | Pretreatment of wet-milled com fiber to improve recovery of com fiber oil and phytosterols 显示文摘 | Vijay Singh David B Johnston Robert A Moreau Kevin B Hicks Bruce S Dien R J Bothast | 2003 | Cereal Chem2003，80，9： | 1 |
| 15 | Outcomes and Complications of Endoscopic Approaches for Malignancies of the Paranasal Sinuses and Anterior Skull Base显示文摘 | Suh Jeffrey D Ramakrishnan Vijay R Chi John J Palmer James N Chiu Alexander G | 2013 | The Annals of Otology Rhinology & Laryngology2013，，1： | 1 |
| 16 | Gastrointestinal Carcinoids: An Increasing Incidence of Rectal Distribution显示文摘 | Avenel Paul McKendrick Alasdair Silapaswan Sumet Kolachalam Ramachandra Kestenberg William Ferguson Lorenzo Jacobs Michael J Goriel Yousif Mittal Vijay | 2010 | The American Surgeon2010，，7： | 1 |
| 17 | Cancer vac- cines and carbohydrate epitopes 显示文摘 | Heimburg-Molinaro J Lure M Vijay G | 2011 | Vaccine2011，29，： | 1 |
| 18 | Reduction and degradation behaviour of sinter under simulated vertical probe trial condition 显示文摘 | Rahamatulla J Angamuthu A Vijay K J | 2008 | ISIJ International2008，48，7： | 1 |
| 19 | DEM - Based Modelling of Surface Runoff Using Diffusion Wave Equation显示文摘 | MANOJ K J VIJAY P S | 2005 | Journal ofHydrology2005，302，： | 1 |
| 20 | Joint scheduling and resource allocation in uplink OFDM systems for broadband wireless access networks显示文摘 | HUANG J VIJAY G S RAJEEV A | 2009 | IEEE J Select Areas Commun2009，27，2： | 1 |
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