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| 1 | Autologous bone marrow derived stem cell therapy in patients with type 2 diabetes mellitus-defining adequate administration methods显示文摘AIM To carry out randomized trial for evaluating effects of autologous bone marrow derived stem cell therapy(ABMSCT) through different routes.METHODS Bone marrow aspirate was taken from the iliac crest of patients. Bone marrow mononuclear cells were separatedand purified using centrifugation. These cells were then infused in a total of 21 patients comprising three groups of 7 patients each. Cells were infused into the superior pancreaticoduodenal artery(Group Ⅰ), splenic artery(Group Ⅱ) and through the peripheral intravenous route(Group Ⅲ). Another group of 7 patients acted as controls and a sham procedure was carried out on them(Group Ⅳ). The cells were labelled with the PET tracer F18-FDG to see their homing and in vivo distribution. Data for clinical outcome was expressed as mean ± SE. All other data was expressed as mean ± SD. Baseline and post treatment data was compared at the end of six months, using paired t-test. Cases and controls data were analyzed using independent t-test. A probability(P) value of < 0.05 was regarded as statistically significant. Measures of clinical outcome were taken as the change or improvement in the following parameters:(1) C-peptide assay;(2) HOMA-IR and HOMA-B;(3) reduction in Insulin dose; subjects who showed reduction of insulin requirement of more than 50% from baseline requirement were regarded as responders; and(4) reduction in HbA 1c. RESULTS All the patients, after being advised for healthy lifestyle changes, were evaluated at periodical intervals and at the end of 6 mo. The changes in body weight, body mass index, waist circumference and percentage of body fat in all groups were not significantly different at the end of this period. The results of intra-group comparison before and after ABMSCT at the end of six months duration was as follows:(1) the area under C-peptide response curve was increased at the end of 6 mo however the difference remained statistically non-significant(P values for fasting C-peptide were 0.973, 0.103, 0.263 and 0.287 respectively and the P values for stimulated C-peptide were 0.989, 0.395, 0.325 and 0.408 respectively for groups Ⅰ?to Ⅳ);(2) the Insulin sensitivity indices of HOMA IR and HOMA B also did not show any significant differences(P values for HOMA IR were 0.368, 0.223, 0.918 and 0.895 respectively and P values for HOMA B were 0.183, 0.664, 0.206 and 0.618 respectively for groups Ⅰto Ⅳ);(3) Group Ⅰshowed a significant reduction in Insulin dose requirement(P < 0.01). Group Ⅱ patients also achieved a significant reduction in Insulin dosages(P = 0.01). The Group Ⅰand Group Ⅱ patients together constituted the targeted group wherein the feeding arteries to pancreas were used for infusing stem cells. Group Ⅲ, which was the intravenous group, showed a non-significant reduction in Insulin dose requirement(P = 0.137). Group Ⅳ patients which comprised the control arm also showed a significant reduction in Insulin dosages at the end of six months(P < 0.05); and(4) there was a non-significant change in the Hb A1 c levels at the end of 6 mo across all groups(P = 0.355, P = 0.351, P = 0.999 and P = 0.408 respectively for groups Ⅰto Ⅳ). CONCLUSION Targeted route showed a significant reduction in Insulin requirement at the end of six months of study period whereas the intravenous group failed to show reduction. | Vikas Sood Anil Bhansali Bhagwant Rai Mittal Baljinder Singh Neelam Marwaha Ashish Jain Niranjan Khandelwal | 2017 | World Journal of Diabetes2017，8，7： | 6 |
| 2 | Facile In Situ Fabrication of Nanostructured Graphene–CuO Hybrid with Hydrogen Sulfide Removal Capacity显示文摘A simple and scalable synthetic approach for one-step synthesis of graphene–Cu O(TRGC) nanocomposite by an in situ thermo-annealing method has been developed.Using graphene oxide(GO) and copper hydroxide as a precursors reagent,the reduction of GO and the uniform deposition of in situ formed Cu O nanoparticles on graphene was simultaneously achieved.The method employed no solvents,toxic-reducing agents,or organic modifiers.The resulting nanostructured hybrid exhibited improved H2 S sorption capacity of 1.5 mmol H2S/g-sorbent(3 g S/100 g-sorbent).Due to its highly dispersed sub-20 nm Cu O nanoparticles and large specific surface area,TRGC nanocomposite exhibits tremendous potential for energy and environment applications. | Sunil P.Lonkar Vishnu V.Pillai Samuel Stephen Ahmed Abdala Vikas Mittal | 2016 | Nano-Micro Letters2016，8，4： | 2 |
| 3 | Attribute performance and customer satisfaction over time: evidence from two field studies显示文摘 | Vikas Mittal Jerome M. Katrichis Pankaj Kumar | 2001 | Journal of Services Marketing2001，，5： | 2 |
| 4 | Satisfaction, repurchase intent, and repurchase behavior: Investigating the moderating effect of customer characteristics显示文摘 | Vikas Mittal Wagner A Kamakura | 2001 | Journal of Marketing Research2001，，2： | 1 |
| 5 | Satisfaction, repurchase intent, and repurchase behavior: Investigating the moderating effect of customer characteristics显示文摘 | Vikas Mittal Wagner A Kamakura | 2001 | Journal of Marketing Research2001，，2： | 1 |
| 6 | Wagner A Kamakura,Satisfaction,repurchase intent,and repurchase behavior:Investigating the moderating effect of customer characteristics 显示文摘 | Vikas Mittal | 2001 | Journal of Marketing Research2001，，： | 1 |
| 7 | Satisfaction, Repurchase Intent, and Repurchase Behavior:Investigating the Mode rating Effect of Customer Characteristics显示文摘 | Mittal Vikas Kamakura Wagner A | 2001 | Journal of Marketing Research2001，38，1： | 1 |
| 8 | Dual emphasis and the long-term financial impact of customer satisfaction显示文摘 | Vikas Mittal Eugene W Anderson Akin Sayrak Pandu Tadikamalla | 2005 | Marketing Science2005，24，4： | 1 |
| 9 | Attribute-level Performance,Satisfaction and Behavioral Intentions over Time:A Consumption-system Approach显示文摘 | Mittal Vikas Lassar | 1998 | Journal of Marketing1998，62，2： | 1 |
| 10 | Regret, A Model of Its Antecedents and Consequences in Consumer Decision Making 显示文摘 | Michael Tsiros Vikas Mittal | 2000 | The Journal of Consumer Research2000，26，4： | 1 |
| 11 | Epoxy-layered silicate nanocomposites and their gas permeation properties 显示文摘 | Maged A Osman Vikas Mittal Massimo Morbidelli | 2004 | Macromolecules2004，37，19： | 1 |
| 12 | Blends of high-density polyethylene with chlorinated polyethylene:morphology,thermal,rheological,and mechanical properties显示文摘 | Chaudhy A U Vikas Mittal | 2013 | Polyme Engineering and Science2013，54，： | 1 |
| 13 | The Role of Attributions in Customer Satsfaetion : A Reexamination 显示文摘 | Tsiros Michael Vikas Mittal William T Ross | 2004 | Journal of Consumer Research2004，，31： | 1 |
| 14 | Strengthening the Satisfaction-Profit Chain显示文摘 | Anderson Eugene W Vikas Mittal | 2000 | Journal of Service Research2000，3，2： | 1 |
| 15 | A Model of its Antecedents and Consequences in Consumer Decision Marketing显示文摘 | Tsiros Michael Vikas Mittal Regret | | 0，，： | 1 |
| 16 | Distinctions Between New and Loyalty Customer显示文摘 | | 2000 | Marketing Research2000，，1： | 1 |
| 17 | Kamakura,Satisfaction,Repurchase Intent,and Repurchase Behavior:Investigation the Moderating Effect of Customer Characteristics显示文摘 | Vikas Mittal and Wagner A | 2001 | Journal of Marketing Research2001，38，： | 1 |
| 18 | Regret: A Model of its Antecedents and Consequences in Consumer Decision Marketing 显示文摘 | Tsiros Michael and Vikas Mittal | 2002 | Journal of Consumer Research2002，，26： | 1 |
| 19 | Satisfaction,repurchase intent,and repurchase behavior:Investigating the moderating effect of customer characteristics显示文摘 | Vikas Mittal Wagner A Kamakura | 2001 | Journal of Marketing Research2001，，2： | 1 |
| 20 | Kamakura, 'Satisfaction, Repurchase Intent, and Repurchase Behavior: Investigation the Moderating Effect of Customer Characteristics' 显示文摘 | Vikas Mittal and Wagner A | 2001 | Journal of Marketing Research2001，38，： | 1 |
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