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| 1 | Validation of a novel animal model for sciatic nerve repair with an adipose-derived stem cell loaded fibrin conduit显示文摘Despite the regenerative capabilities of peripheral nerves, severe injuries or neuronal trauma of critical size impose immense hurdles for proper restoration of neuro-muscular circuitry. Autologous nerve grafts improve re-establishment of connectivity, but also comprise substantial donor site morbidity. We developed a rat model which allows the testing of different cell applications, i.e., mesenchymal stem cells, to improve nerve regeneration in vivo. To mimic inaccurate alignment of autologous nerve grafts with the injured nerve, a 20 mm portion of the sciatic nerve was excised, and sutured back in place in reversed direction. To validate the feasibility of our novel model, a fibrin gel conduit containing autologous undifferentiated adipose-derived stem cells was applied around the coaptation sites and compared to autologous nerve grafts. After evaluating sciatic nerve function for 16 weeks postoperatively, animals were sacrificed, and gastrocnemius muscle weight was determined along with morphological parameters(g-ratio, axon density & diameter) of regenerating axons. Interestingly, the addition of undifferentiated adipose-derived stem cells resulted in a significantly improved re-myelination, axon ingrowth and functional outcome, when compared to animals without a cell seeded conduit. The presented model thus displays several intriguing features: it imitates a certain mismatch in size, distribution and orientation of axons within the nerve coaptation site. The fibrin conduit itself allows for an easy application of cells and, as a true critical-size defect model, any observed improvement relates directly to the performed intervention. Since fibrin and adipose-derived stem cells have been approved for human applications, the technique can theoretically be performed on humans. Thus, we suggest that the model is a powerful tool to investigate cell mediated assistance of peripheral nerve regeneration. | Maximilian M.Saller Rosa-Eva Huettl Julius M.Mayer Annette Feuchtinger Christian Krug Thomas Holzbach Elias Volkmer | 2018 | Neural Regeneration Research2018，13，5： | 4 |
| 2 | Focal atrial tachycardia originating from the musculature of the coronary sinus显示文摘 | Antz M Hebe J | 2002 | J Cardiovasc Electrophysiol2002，13，1： | 1 |
| 3 | Tissue engineering for bone defect healing:an update on a multi-component approach显示文摘 | Drosse I Volkmer E Capanna R | | 0，，2： | 1 |
| 4 | Substrate mapping vs tachycardia mapping using CARTO in patients with coronary artery disease and ventricular tachycardia: impact on outcome of catheter ablation 显示文摘 | Volkmer M Ouyang F Deger F | 2006 | Europace2006，8，： | 1 |
| 5 | Lessons learned from1,000 neobladders:the 90-day complication rate显示文摘 | Hautmann R E de-Petriconi R C Volkmer B G | 2010 | J Urol2010，184，3： | 1 |
| 6 | Cancer stem cells in bladdercancer: a revisited and evolving concept 显示文摘 | Chan KS Volkmer JP Weissman I | 2010 | Curr Opin Urol2010，20，5： | 1 |
| 7 | Long-term results of standard procedures in urology:the ileal neobladder显示文摘 | Hautmann RE Volkmer BG Schumacher MC | | 0，，03： | 1 |
| 8 | Urinary diversion 显示文摘 | World Health Organization (WHO) Conference in Bladder Cancer Hautmann RE Abol-Enein H Hafez K Haro I Mansson W Mills RD Montie JD Sagalowsky AI Stein JP Stenzl A Studer UE Volkmer BG | 2007 | Urology2007，，： | 1 |
| 9 | Coherence Length of Photons from a Single Quantum System显示文摘 | JELEZKO F VOLKMER A WRACHTRUP J | 2003 | Phys Rev A2003，67，04： | 1 |
| 10 | Long-term results of standard procedures in urology:the ileal neobladder显示文摘 | Hantmann RE Volkmer BG Schumacher MC | | 0，，03： | 1 |
| 11 | Human homologs of Schizosaccharomyces pombe radl,husl,and rad9 form aDNA damage-responsive protein complex显示文摘 | Volkmer E Karnitz L M | 1999 | J Biol Chem1999，274，2： | 1 |
| 12 | Cretaceous - Tertiary structural evolution of the north central Lhasa terrane, Tibet 显示文摘 | VOLKMER J E KAPP P GUYNN J H | 2007 | Tectonics2007，26，6： | 1 |
| 13 | Synthetic peptide arrays for in- vestigating protein interaction domains 显示文摘 | Volkmer R Tapia V Landgraf C | 2012 | FEBS Letters2012，586，17： | 1 |
| 14 | Vibrational Imaging with High Sensitivity Viaepi-detected Coherent Anti-stokes Raman Scattering Microscopy 显示文摘 | VOLKMER A CHENG J X SUNNEY X X | 2001 | Phys Rev Lett2001，87，02： | 1 |
| 15 | Ultrathin Composite Films Incorporating the Nanoporous Isopolyoxomolybdate ' Keplerate ' ( NH4 )42 显示文摘 | Kurth D G Volkmer D Ruttorf M | 2000 | Chemistry of Materials2000，12，： | 1 |
| 16 | UVA-induced DNA double-strand breaks result from the repair of clustered oxida tire DNA damages 显示文摘 | Greinert R Volkmer B Henning S | 2012 | Nucleic Acids Res2012，40，10： | 1 |
| 17 | Theoretical andexperimental characterization of coherent anti-StokesRaman scattering microscopy 显示文摘 | Cheng J X Volkmer A Xie X S | 2002 | JOSA B2002，19，6： | 1 |
| 18 | Surgical intervention for complications of tension free vaginal tape procedure 显示文摘 | Volkmer BG Nesslauer T Rinnab L | 2003 | J Urol2003，169，2： | 1 |
| 19 | Tissue engineering for bone defect healing: an update on a multi-component approach 显示文摘 | Drosse I Volkmer E Capanna R | 2008 | Injury2008，39，2： | 1 |
| 20 | Polyoxometalate-Based Electro-and Photochromic Dual-Mode Devices显示文摘 | Liu Shaoqin Mohwald H Volkmer D | 2006 | Langmuir2006，22，： | 1 |
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