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| 1 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 2 | Rehospital initiation of tiro? ban in patients with ST elevation myocardial in farction undergoing primary angioplasty (On-TIME 2): multicentre, double blind, randomised controlled trial 显示文摘 | Van't Hof AW Berg JT Ton HP | 2008 | Lancet2008，372，9638： | 1 |
| 3 | Dendritic cells, Fe γ receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis 显示文摘 | Radstake TR van Lieshout AW van Riel PL | 2005 | Ann Rheum Dis2005，64，11： | 1 |
| 4 | Ambulatory monitoring to assess real-life cardiovascular reactivity in type A and type B subjects显示文摘 | Van EGEREN LF SPARROW AW | 1990 | Psychosom Med1990，52，3： | 1 |
| 5 | Microsatellite analysis of microdissected tumor cells and 6p high density microsatellite analysis in head and neck squamous cell carcinomas with down-regulated human leukocyte antigen class Ⅰ expression 显示文摘 | Feenstra M Verdaasdonk M van der Zwan AW | 2000 | Lab Invest2000，80，： | 1 |
| 6 | Circulation CXCL16 is not related to circulation ox LDL in patients with rheumatoid arthritis 显示文摘 | van Lieshout AW Popa C Meyer-Wentrup F | 2007 | Boochem Biophys Res Commun2007，355，2： | 1 |
| 7 | Flav onoid andchlorogenic acid levels inapple fruit: char acterisation of variation显示文摘 | AW AD M A JAGER A D van WESTING L M | 2000 | Scientia Horticulturae2000，83，34： | 1 |
| 8 | Hetero- duplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations 显示文摘 | Langerak AW Szczepafiski T van der Burg M | 1997 | Leuke- mia1997，11，12： | 1 |
| 9 | Effects of hypothermia and gender on survival and behavior after perinatal asphyxia in rats显示文摘 | Loidl CF Gavilanes AW Van Dijk EH | 2000 | Physiol Behav2000，68，： | 1 |
| 10 | Long-term restoration of the human T-cell compartment after thymectomy during infancy: a role for thymic regeneration?显示文摘 | van Gent R Schadenberg AW Otto SA | 2011 | Blood2011，118，3： | 1 |
| 11 | Carotid artery plaque burden, stiffness, and mortality risk in elderly men: a prospective, population-based cohort study显示文摘 | Stork S van den Beld AW von Schacky C | 2004 | Circulation2004，110，3： | 1 |
| 12 | Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ ABCG2 drag pump显示文摘 | Burger H Van TH Boersma AW | 2004 | Blood2004，104，9： | 1 |
| 13 | Time-to-treatment significantly affects the extent of ST-segment resolution and myocardial blush in patients with acute myocardial infarction by primary angioplasty显示文摘 | de Luca G Van't Hof AW de Boer MJ | 2004 | Eur Heart J2004，25，12： | 1 |
| 14 | Comparison between stenting and balloon angioplasty in patients undergoing primary angioplasty of small coronary vessels显示文摘 | De Luca G Suryapranata H van' t Hof AW | 2006 | Am Heart J2006，152，5： | 1 |
| 15 | Unsuccessful reperfusion in patients with ST-segment elevation myocardial infarction treated by primary angioplasty显示文摘 | De Luca G van 't Hof AW Ottervanger JP | 2010 | Am Heart J2010，150，5： | 1 |
| 16 | Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936 显示文摘 | van Dongen JJ Langerak AW Bruggemann M | 2003 | Leukemia2003，17，12： | 1 |
| 17 | Impaired myocardial perfusion is a major explanation of the poor outcome observed in patients undergoing primary angioplasty for ST-segment-elevation myocardial infarction and signs of heart failure 显示文摘 | De Luca G van't Holf AW De Boer MJ | 2004 | Circulation2004，109，8： | 1 |
| 18 | Endothelial dysfunction precedes development of microalbuminuria in IDDM显示文摘 | Stehouwer CD Fischer HR van Kuijk AW | 1995 | Diabetes1995，44，5： | 1 |
| 19 | Facilitation of primary coronary angioplasty by early start of a glycoprotein 2b/3a inhibi- tor: results of the ongoing tirofiban in myocardial infarction evalua- tion (On-TIME) trial显示文摘 | van't Hof AW Ernst N de Boer MJ | 2004 | Eur Heart J2004，25，10： | 1 |
| 20 | An early prediction of delirium in the acute phase af- ter stroke 显示文摘 | Oldenbeuving AW De Kort PL Van Eck van der Sluijs JF | 2013 | J Neurol Neurosurg Psychiatry2013，85，4： | 1 |
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