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| 1 | Management of recurrent rectal cancer:A population based study in greater Amsterdam显示文摘AIM: To analyze,retrospectively in a population-based study,the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorectal excision (TME). METHODS: All rectal carcinomas diagnosed during 1998 to 2000 and initially treated with a macroscopically radical resection (632 patients) were selected from the Amsterdam Cancer Registry. For patients with recurrent disease,information on treatment of the recurrence was collected from the medical records. RESULTS: Local recurrence with or without clinically apparent distant dissemination occurred in 62 patients (10%). Thirty-two patients had an isolated local recurrence. Ten of these 32 patients (31%) underwent radical re-resection and experienced the highest survival (three quarters survived for at least 3 years). Eight patients (25%) underwent non-radical surgery (median survival 24 mo),seven patients (22%) were treated with radio-and/or chemotherapy without surgery (median survival 15 mo) and seven patients (22%) only received best supportive care (median survival 5 mo). Distant dissemination occurred in 124 patients (20%) of whom 30 patients also had a local recurrence. The majority (54%) of these patients were treated with radio-and/or chemotherapy without surgery (median survival 15 mo). Twenty-seven percent of these patients only received best supportive care (median survival 6 mo),while 16% underwent surgery for their recurrence. Survival was best in the latter group (median survival 32 mo). CONCLUSION: Although treatment options and survival are limited in case of recurrent rectal cancer after radical local resection obtained with TME,patients can benefit from additional treatment,especially if a radical resection is feasible. | Roel Bakx Otto Visser Judith Josso Sybren Meijer J Frederik M Slors J Jan B van Lanschot | 2008 | World Journal of Gastroenterology2008，14，39： | 17 |
| 2 | 25-羟维生素D和甲状旁腺激素与高血压的相关性显示文摘有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。 | van Ballegooijen AJ Kestenbaum B Sachs MC de Boer IH Siscovick DS Hoofnagle AN Ix JH Visser M Brouwer IA 练桂丽 叶鹏 | 2014 | 中华高血压杂志2014，22，6： | 10 |
| 3 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 4 | 泵站开敞式进水池流动特性数值模拟显示文摘为深入研究开敞式进水池的内部流态,基于定常不可压流体的控制方程和重整化群(RNG)湍流模型,采用CFD技术,通过SIMPLEC算法,计算其三维流动,获得整体流场结果,揭示了泵站进水池水流运动规律.研究表明,进水池内流动可分为进水池直段、喇叭口吸水和进水管内流动3个阶段,各阶段的流动特征不同.在进水池喇叭管的下方、进水池水面附近吸水管靠后壁处、进水池两个边角及侧边壁下方靠近底部处等区域是易形成旋涡的主要位置,须采用措施进行预防. | 成立 刘超 van ESCH B P M 周济人 金燕 | 2009 | 扬州大学学报(自然科学版)2009，12，2： | 5 |
| 5 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 6 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 7 | Experimental and theoretical study of the swirling flow in centrifugal compressor volute显示文摘 | Van den Braembussche R A Hand B M | 1990 | ASME Journal of Turbornachinery1990，112，3： | 2 |
| 8 | Strategies of heavy metal uptake by three plant species growing near a metal smelter显示文摘 | H Dahmani-Muller F van Oort B Gélie M Balabane | 2000 | Environmental Pollution2000，，2： | 2 |
| 9 | Apoptosis in developing anthers and the role of ABA in this process during androgenesis in Hordeum vulgate L显示文摘 | WANG M HOEKSTRA S VAN BERGEN S LAMERS GEM OPPEDIJK B J VAN DER HEUDEN M W DE PRIESTER W SCHILPEROORT RA 1 | 1999 | Plant Mol Biol1999，39，： | 1 |
| 10 | Flip PCR for DNA sequence motif invertion 显示文摘 | Schanke J T Quam L M Van Ness B G | 1994 | Bio Techniques1994，16，3： | 1 |
| 11 | General combining ability of six g-enotypes of spring wheat for biscuitquality characteristic 显示文摘 | LABUSCIIANGE M T COETZEE M C B VAN DEVENTER C S | 1996 | Plant-Breeding1996，115，4： | 1 |
| 12 | Focused crawling: a new approach to topic-specific Web resource discovery显示文摘 | CHARKRABARTI S BERG M van den DOM B | 1999 | Computer Networks1999，31，1116： | 1 |
| 13 | Inhi- bition of Denitrification Activity but not of mRNA Induction in Paracoccus denitrificans by Nitrite at a Suboptimal pH 显示文摘 | BAUMANN B VAN DER MEER J R SNOZZI M | 1997 | Antonie van Leeuwenhoek1997，72，： | 1 |
| 14 | Usefulness of clinical, echocardiographic, and procedural characteristics to predict outcome after percutaneous transluminal septal myocardial ablation显示文摘 | VAN DER LEE C SCHOLZEL B TEN BERGJ M | 2008 | Am J Cardiol2008，101，： | 1 |
| 15 | A combination of anti-CD3 and anti-CD7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease 显示文摘 | Liesbeth van Emst Anton V M B Schattenberg | 2000 | Blood2000，95，12： | 1 |
| 16 | A contin uous-flow crushing device for on-line δ^2 H analysis of fluid inclusion water in speleothems显示文摘 | Vonhof H B van Breukelen M R Postma O | 2006 | Rapid Communications in Mass Spectrometry2006，20，17： | 1 |
| 17 | Influenza infection and risk of acute pulmonary embolism显示文摘 | van Wissen M Keller T Ronkes B | 2007 | Thromb J2007，5，1： | 1 |
| 18 | Persistent immune activation in HIV-1 infection is associated with progression to AIDS显示文摘 | Hazenberg M D Otto S A van Benthem B H | 2003 | AIDS2003，17，： | 1 |
| 19 | Persistent immune activation in HIV-1 infection is associated with progression to AIDS显示文摘 | Hazenberg M D Otto S A van Benthem B H | 2003 | AIDS2003，17，： | 1 |
| 20 | Balance control in patients with distal versus proximal muscle weakness显示文摘 | HORLINGS C G KUNG U M VAN ENGELEN B G | 2009 | Neuroscience2009，164，4： | 1 |
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