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| 1 | Progression of intervention-focused research for Gulf War illness显示文摘The Persian Gulf War of 1990 to 1991 involved the deployment of nearly 700,000 American troops to the Middle East.Deployment-related exposures to toxic substances such as pesticides,nerve agents,pyridostigmine bromide(PB),smoke from burning oil wells,and petrochemicals may have contributed to medical illness in as many as 250,000 of those American troops.The cluster of chronic symptoms,now referred to as Gulf War Illness(GWI),has been studied by many researchers over the past two decades.Although over$500 million has been spent on GWI research,to date,no cures or condition-specific treatments have been discovered,and the exact pathophysiology remains elusive.Using the 2007 National Institute of Health(NIH)Roadmap for Medical Research model as a reference framework,we reviewed studies of interventions involving GWI patients to assess the progress of treatment-related GWI research.All GWI clinical trial studies reviewed involved investigations of existing interventions that have shown efficacy in other diseases with analogous symptoms.After reviewing the published and ongoing registered clinical trials for cognitivebehavioral therapy,exercise therapy,acupuncture,coenzyme Q10(CoQ10),mifepristone,and carnosine in GWI patients,we identified only four treatments(cognitive-behavioral therapy,exercise therapy,CoQ10,and mifepristone)that have progressed beyond a phase II trial.We conclude that progress in the scientific study of therapies for GWI has not followed the NIH Roadmap for Medical Research model.Establishment of a standard case definition,prioritized GWI research funding for the characterization of the pathophysiology of the condition,and rapid replication and adaptation of early phase,single site clinical trials could substantially advance research progress and treatment discovery for this condition. | Jeremy E.Chester Mazhgan Rowneki William Van Doren Drew A.Helmer | 2020 | Military Medical Research2020，7，1： | 3 |
| 2 | HMG-CoA reductase guides migrating primordial germ cells显示文摘 | van Doren M Broihier H T Moore L A | 1998 | Nature1998，396，6710： | 1 |
| 3 | Power Bus Decoupling on Multiplayer Printed Circuit Board显示文摘 | DREWNIAK J L HUBING T H VAN DOREN T P | 1995 | IEEE Trans on EMC1995，37，2： | 1 |
| 4 | Ab initio study of the elastic properties of single-walled carbon nanotubes and graphene显示文摘 | Van Lier G Van Alsenoy C Van Doren V | 2000 | Chem Phys Lett2000，326，： | 1 |
| 5 | Pow- er-bus decoupling on muhilayer printed circuit boards 显示文摘 | Hubing J H Drewniak J L Van Doren T P | 1995 | IEEE Trans Electromagn Compat1995，37，2： | 1 |
| 6 | An Empirically Based Model of Competitor Intelligence Use显示文摘 | Peyrot M Childs N Van Doren D Allen K | 2002 | Journal of Business Research2002，55，9： | 1 |
| 7 | Parameters for characterizing tillage-induced soil surface roughness显示文摘 | Linden D R Van Doren D M | 1986 | Soil Science Society of America Journal1986，50，6： | 1 |
| 8 | Free nipple grafting: an alternative for patients ineligible for nipple-sparing mastectomy? 显示文摘 | Doren EL Van Eldik Kuykendall L Lopez JJ | 2014 | Ann Plast Surg2014，72，6： | 1 |
| 9 | Movie induced tourism显示文摘 | Riley R Baker D Van Doren C S | 1998 | Annals of Tourism Research1998，25，4： | 1 |
| 10 | Abdominal-B is essential for proper sexually dimorphic development of the Drosophila gonad 显示文摘 | DeFalco T Le Bras S Van Doren M | 2004 | Mech Dev2004，121，11： | 1 |
| 11 | Movies as tourism promotion: A 'pull' factor in a 'push' location 显示文摘 | Riley R W Van Doren C S | 1992 | Tourism Management1992，13，3： | 1 |
| 12 | Movie Induced 1 Tourism显示文摘 | R.iley R D. Baker C. Van Doren | | 0，，04： | 1 |
| 13 | Movies as tourism promotion: A 'pull' factor in a 'push' location显示文摘 | Riley tk. W Van Doren C. S | | 0，，： | 1 |
| 14 | Movie induced tourism显示文摘 | Roger Riley Dwayne Baker Carltons Van Doren | | 0，，04： | 1 |
| 15 | Movie induced tourism显示文摘 | Riley R Swayne Baker Van Doren C | 1998 | Annals of Tourism Research1998，25，4： | 1 |
| 16 | Clean construction protocol for the National Ignition Facility beampath and utilities显示文摘 | Sommer S C Stowers I F van Doren D E | 2003 | Journal of the IEST2003，46，1： | 1 |
| 17 | Foodborne illness outbreaks from microbial contaminants in spices, 1973-2010 显示文摘 | Van Doren JM Neil KP Parish M | 2013 | Food Microbiol2013，36，2： | 1 |
| 18 | Solar-cell design based on a distributed diode analysis显示文摘 | Boone J L Van Doren T P | 1978 | IEEE Transaction on Electron Devices1978，25，7： | 1 |
| 19 | Spatial analysis of the US lodging industry, 1963-1977显示文摘 | Van Doren C S Gustke L D | 1982 | Annals of Tourism Research1982，9，4： | 1 |
| 20 | Movies as tourism promotion: A ‘pull' factor in a ‘push' location 显示文摘 | Riley R W Van Doren C S | 1992 | Tourism Management1992，13，3： | 1 |
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