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| 1 | Medically unexplained dyspnea:psychophysiological characteristics and role of breathing therapy显示文摘Background Medically unexplained dyspnea occurs commonly in medical settings and remains poorly understood. This study was conducted to investigate the psychophysiological characteristics of medically unexplained dyspnea and the efficacy of breathing retraining for these patients. Methods A group of patients with medically unexplained dyspnea were compared to patients with a variety of organic lung diseases and healthy subjects. In another group of patients,the influence of breathing therapy on complaints,anxiety, and breath-holding was evaluated for an average of 1.5 years. Results Patients with medically unexplained dyspnea reported more intense dyspnea than patients with a variety of organic lung diseases. Additionally,they were anxious and presented a broad range of symptoms in daily life and under challenge,for instance voluntary hyperventilation. More than one third of them qualified for panic disorder. They had shorter breath-holding time at rest,less increase in breath-holding time and higher chances of showing a “paradoxical” decrease of breath-holding time after hyperventilation. A combination of PaO2,forced expiratory volume in one second (FEV1),and anxiety measures distinguished them from organic dyspnea. Breathing retraining profoundly improved their symptoms and decreased the level of state and trait anxiety. Moreover,they better tolerated the voluntary hyperventilation and the symptoms induced were also markedly decreased after therapy. Breath-holding time was prolonged and PetCO2 in a representative group of patients increased. Conclusions Patients with medically unexplained dyspnea appear to have the feature of a “psychosomatic” patient: an anxious patient with a wide variety of symptoms of different organ systems that do not have an organic basis. They can be distinguished from organic dyspnea using a small set of physiological and psychological measures. Breathing retraining turns out to be an effective therapy for those “difficult to treat patients”. | 韩江娜 朱元珏 李舜伟 雒冬梅 胡征 Van Diest I De Peuter S Van de Woestijne KP Van den Bergh O | 2004 | Chinese Medical Journal2004，，1： | 10 |
| 2 | 高通气综合征?还是惊恐障碍?显示文摘 | 韩江娜 R Schepers K Stegen O Van den Bergh KP Van de Woestijne | 2001 | 中华结核和呼吸杂志2001，24，9： | 9 |
| 3 | 动态肺量测定在支气管哮喘中的应用显示文摘目的探讨动态肺量测定技术在支气管哮喘中的应用。方法建立动态肺量测定技术,对20例支气管哮喘患者每天清晨、下午和入睡前连续14d动态监测气道功能、症状和情绪。结果白天标准肺功能检查结果正常的支气管哮喘患者,第一秒用力呼气量(FEV1)和最大呼气峰流量(PEF)在夜间和凌晨可出现明显下降。肺功能指标与支气管哮喘症状的相关分析发现,只有7例患者(35%)支气管哮喘症状与FEV1和PEF存在相关关系。4例患者(20%)肺功能基本正常,但有很多症状,症状与FEV1和PEF无相关关系,但与负面情绪相关。另外2例患者(10%)肺功能损害严重,但几乎没有症状。结论动态肺量测定技术能客观反映支气管哮喘患者气道功能的昼夜自然变化,因此可以更准确地反映支气管哮喘的严重程度。动态肺量测定技术结合症状和情绪的同步监测,可以帮助识别出特殊症状感觉类型的支气管哮喘患者。 | 尹小文 韩江娜 朱元珏 许文兵 KP Van de Woestijne O Van den Bergh | 2005 | 中国医学科学院学报2005，27，3： | 6 |
| 4 | 少年儿童非器质性呼吸困难34例分析显示文摘目的 总结分析 1996~ 2 0 0 2年间在北京协和医院诊断的 34例少年儿童非器质性呼吸困难病例。方法 非器质性呼吸困难的临床诊断标准 :有突出的呼吸困难 ,经过询问病史、体格检查和相关的实验室检查 ,没有心肺或其他器质性病因。结果 少年儿童非器质性呼吸困难最小发病年龄 8岁 ,13~ 16岁为高峰发病年龄 ,17岁以后发病人数明显减少。大多数为慢性病程 ,伴症状急性发作。表现为呼吸困难 ,伴随明显的过度通气、低碳酸血症的症状。少年儿童患者焦虑不明显 ,与成人形成鲜明对比。多数患儿有明显的心因性诱因 ,中学阶段学习压力大为最重要的诱因。 13例患儿接受腹式呼吸训练治疗 2~ 3个月后复查 ,呼吸困难和伴随症状得到明显改善。结论 少年儿童非器质性呼吸困难呈慢性过程 ,需要引起足够的重视 ,提高医师警觉性是正确诊断处理的关键。 | 韩江娜 朱元珏 李舜伟 雒冬梅 尹小文 陈育智 O Van den Bergh KP Van de Woestijne | 2004 | 中华儿科杂志2004，42，4： | 3 |
| 5 | Inhaled nitric oxide for premature infants with severe respiratory failure显示文摘 | Van Meurs KP Wright LL Ehrenkranz RA | 2005 | N Engl J Med2005，353，1： | 1 |
| 6 | Assessment of future remnant liver function using hepatobiliary scintigraphy in patients undergoing major liver resection显示文摘 | de Graaf W van Lienden KP Dinant S | 2010 | J Gastrointest Surg2010，14，2： | 1 |
| 7 | Reconstitution of the vascular wall in vitro: A novel model to study interactions between endothelial and smooth muscle cells显示文摘 | van Bull - Wortelboer MF Brinkman HJM Dingemans KP | 1986 | Exp Cell Res1986，162，： | 1 |
| 8 | Effect of Scale on the Links Between Walking and Urban Design显示文摘 | Learnihan V Van Niel KP Giles-Corti B | 2011 | Geographical Research2011，49，2： | 1 |
| 9 | Treatment evolution in high-risk congenital diaphragmatic hernia:Ten years'experience with diaphragmatic agenesis显示文摘 | Lally KP Lally PA Van Meurs KP | 2006 | Ann Surg2006，244，4： | 1 |
| 10 | (99m)Tc-me-brofenin hepatobiliary scintigraphy with SPECT for the assessment of hepatic function and liver functional volume before partial hepatectomy显示文摘 | de Graaf W van Lienden KP van Gulik TM | 2010 | J Nucl Med2010，51，2： | 1 |
| 11 | Venoarterial versus venovenousECMO for neonatal respiratory failure 显示文摘 | Rais-Bahrami K Van Meurs KP | 2014 | Semin Perinatol2014，38，2： | 1 |
| 12 | Plasma vascular endothelial growth factor in severe sepsis显示文摘 | Vander Flier M Van Leeuwen HJ Van Kessel KP | 2005 | Shock2005，23，1： | 1 |
| 13 | Mission to eliminate postinjury abdominal compartment syndrome显示文摘 | Balogh ZJ Martin A van Wessem KP | 2011 | Arch Surg2011，146，8： | 1 |
| 14 | Hypothermia therapy for neonatal hypoxic ischemic encephalopathy in the state of California显示文摘 | Kracer B Hintz SR Van Meurs KP | 2014 | J Pediatr2014，165，2： | 1 |
| 15 | Does sleep depriva-tion alter functional EEG networks in children with focal epilep sy? 显示文摘 | van Diessen E Otte WM Braun KP | 2014 | Front Syst Neurosci2014，29，5： | 1 |
| 16 | Subintimal augioplasty for peripheral arterial occlusive disease : a systematic review 显示文摘 | Met R Van Lienden KP Koelemay MJ | 2008 | Cardiovasc lntervent Radiol2008，31，4： | 1 |
| 17 | Neutrophils mediate immune modulation of dendritic cells through glycosylation- dependent interactions between Mac- 1 and DC-SIGN显示文摘 | van Gisbergen KP Sanchez-Hernandez M Geijtenbeek TB | 2005 | J Exp Med2005，201，： | 1 |
| 18 | Subintimal Angioplasty for peripheral arterial occlusive disease: a systematic review 显示文摘 | Met R Van Lienden KP Koelemay M J | 2008 | Caidiovasc Intervent Radiol2008，31，4： | 1 |
| 19 | Endovenous laser ablation-induced complications:review of the literature and new cases显示文摘 | van den Bos RR Neumann M De Roos KP | 2009 | Dermatol Surg2009，35，8： | 1 |
| 20 | Cognitive outcome after epi- lepsy surgery in children显示文摘 | Van Schooneveld MM Braun KP | 2013 | Brain Dev2013，35，： | 1 |
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