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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 3 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 4 | Closed- loop supply chain models with product remanufacturing 显示文摘 | Savaskan R C Bhattacharya S Van Wassenhovel N | 2004 | Management Science2004，50，2： | 1 |
| 5 | Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol显示文摘 | ABUCHOWSKI A VAN ES T PALCZUK N C | 1977 | J Biol Chem1977，252，11： | 1 |
| 6 | Various behavioral signs of estrus and their relationship with time of ovulation in dairy cattle显示文摘 | Roelofs J B van Eerdenburg F J C M Soede N M | 2005 | Theriogenology2005，63，5： | 1 |
| 7 | Liquid chromatographic method for the quantitative determina- tion of Nepsilon-carboxymethyllysine in human plasma proteins 显示文摘 | Van de Merbel N C Mentink C J Hendriks G | 2004 | Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences2004，808，2： | 1 |
| 8 | An iterated dynasearch algorithm for the single-machine total weighted tardiness scheduling problem显示文摘 | Congram R K Potts C N van de Velde S | 2002 | Informs Journal on Computing2002，14，： | 1 |
| 9 | 查看详情显示文摘 | Mijatovic T De Nève N Bruyère C Simon G Dewelle J Van Quaquebeke E Van Der A.E Van Vynckt F Lefranc F Kiss R | | 0，，： | 1 |
| 10 | Design of a stroke dependent damper for the front axle suspension of a truck using multibody system dynamics and numerical optimization显示文摘 | Etman L F P Vernmeulen R C N Van Heck J G A M | | 0，，02： | 1 |
| 11 | By any means necessary: Theeffects ofregula- tory focus and moral conviction on hostile and benevolent forms of collectiveaction 显示文摘 | ZAAL M P VAN LAAR C STHAL T ELLEMERS N DERKS B | 2011 | British Journal of Social Psychology2011，50，： | 1 |
| 12 | Closed-loop supply chain models with product remanufacturing 显示文摘 | Savaskan R C Bhanttacharya S Van Wassenhove L N | 2004 | Management Science2004，50，2： | 1 |
| 13 | Closed-loop supply chain models with product re- manufacturing显示文摘 | SAVASKAN R C BHATTACHARYA S VAN WASSEN- HOVE L N | 2004 | Management Science2004，50，2： | 1 |
| 14 | (Anti) estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture 显示文摘 | VAN MEEUWEN J A KORTHAGEN N DE JONG P C | 2007 | Toxicol Appl Pharmacol2007，221，3： | 1 |
| 15 | The effect of aprotinin,tranexamic acid,and aminocaproic acid on blood loss and use of blood products in major pediatric surgery:A meta-analysis显示文摘 | SCHOUTEN E S VAN DE POL A C SCHOUTEN A N | 2009 | Pediatr Crit Care Med2009，10，2： | 1 |
| 16 | Prediction of the occurrence of slope instability phenomena through GIS based hazard zonation显示文摘 | Van Westen C J Rengers N Terlien M T J | 1997 | Geologische Rundschau1997，86，4： | 1 |
| 17 | Aluminum chemistry in a forested Spodosol显示文摘 | Driscoll C T Van B N Mulder J | 1985 | Soil Sci Soc Am J1985，49，： | 1 |
| 18 | Endogenous Ⅱ-6 and Ⅱ-10 contribute to the differentiation of CD40 activated human B lymphocytes 显示文摘 | BURDIN N VAN KOOTEN C GALIBERT L | 1995 | J Immunol1995，154，6： | 1 |
| 19 | Use of thefluorescent timer DsRed-E5 as reporter to monitor dynamics ofgene activity in plants 显示文摘 | Mirabella R Franken C van der Krogt G N ef al | 2004 | Plant Physiol2004，135，4： | 1 |
| 20 | Closed-loop supply chain models with product re- manufacturing 显示文摘 | SAVASKAN R C BHATTACHARYA S VAN WASSEN- HOVE L N | 2004 | Management Science2004，50，2： | 1 |
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