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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | Cavity enhanced absorption spectroscopy for N_2O detection at 2.86 μm using a continuous tunable color center laser显示文摘The cavity enhanced absorption technique is applied to N2O detection around 2.86 μm using a continuouswave color center laser. A high-finesse triangular ring cavity is used in this technology. Transmission through the cavity is obtained by jittering the cavity-length with a piezo on one of the cavity mirrors.A minimum detectable absorption coefficient of 2 × 10-6 cm-1 is achieved with a mirror reflectivity of 99.24%, corresponding to a N2O detection limit of 600 parts per billion. | 李少成 于清旭 Maarten van Herpen Sacco te Lintel Hekkert Frans J.M.Harren | 2003 | Chinese Optics Letters2003，1，6： | 3 |
| 4 | Activation of the Complement System During and After Cardiopulmonary Bypass Surgery: Postsurgery Activation Involves C-Reactive Protein and Is Associated With Postoperative Arrhythmia显示文摘 | Peter Bruins Henk te Velthuis Aria P. Yazdanbakhsh Piet G.M. Jansen Fred W.J. van Hardevelt Eddy M.F.H. de Beaumont Charles R.H. Wildevuur Leon Eijsman NA Trouwborst C. Erik Hack | 1997 | Circulation1997，，10： | 2 |
| 5 | Moesin functions as a lipopolysaccharide receptor on human monocytes显示文摘 | Tohme ZN Amar S van Dyke TE | 1999 | Infect Immun1999，67，： | 1 |
| 6 | Effect of genetic variants of the heart fatty acid-binding protein gene on intramuscular fat and performan-ce traits in pigs显示文摘 | A J van Erp F L Hardem F J Verburg T H Meuwissen J HVeerkamp and M F te Pas | | 0，，04： | 1 |
| 7 | Study on composites of Nylon-6 with hollow glass microspheres显示文摘 | Te N K Addink R Van der Vegt A K | 1989 | Polymer Bulletin (Berlin)1989，21，5： | 1 |
| 8 | Inflammatory signal transduction in Crohn's disease and novel therapeutic approaches显示文摘 | Van Montfrans C Peppelenbosch M Te Velde A A | 2002 | Biochem Pharmacol2002，64，： | 1 |
| 9 | Liver transplantation显示文摘 | Starzl TE Demetris AJ van Thiel DH | 1989 | N Engl J Med1989，321，： | 1 |
| 10 | Liver transplant显示文摘 | Starzl TE Demetris AJ Van Thiel DH | 1989 | Nengl J Med1989，321，： | 1 |
| 11 | Evidence based selection of housekeeping genes显示文摘 | de Jonge H J Fehrmann R S de Bont E S Hofstra R M Gerbens F Kamps W A de Vries E G van der Zee A G te Meerman G J ter Elst A | | 0，，： | 1 |
| 12 | The hepatocyte growth factor/ Met pathway in development,tumorigenesis,and Bcell differentiation显示文摘 | van der Voort R Taher TE Derksen PW | 2000 | Adv Cancer Res2000，79，1： | 1 |
| 13 | Prevalence of gingival diseases, malo- celusion and fluorosis in school going ehil dren of rural areas in Udaipur district显示文摘 | Dhar V Jain A Van Dyke TE etal | 2007 | J Indian Soc Pedod Prey Dent2007，25，10： | 1 |
| 14 | Clinica outcome of Crohn's disease according to the Vienna classification:disease location is a useful predictor of disease course显示文摘 | Oostenbrug LE van Dullenmen HM te Meerman GJ | 2006 | Eur J Gastroenterol Hepatol2006，18，3： | 1 |
| 15 | Hyperhomocysteinemia a risk factor for ischemic stroke in children显示文摘 | van Beynum IM Smeitink JA den Heijer M te Poele Pothoff MT Blom HJ | 1999 | Circulation1999，99，16： | 1 |
| 16 | Enamel matrix derivative promotes superoxide production and chemotaxis but reduces matrix metalloproteinase-8 expression by polymorphonuclear leukocytes显示文摘 | Karima MM Van Dyke TE | 2012 | J Periodontol2012，83，6： | 1 |
| 17 | Methods of cooling:practical aspects of therapeutic temperature management显示文摘 | Seder DB Van der Kloot TE | 2009 | Crit Care Med2009，37，7： | 1 |
| 18 | Flow cytometric detection of intracellular antigens for immunophenotyping of normal and malignant leukocytes 显示文摘 | Groeneveld K Te Marvelde JG van den Beemd MWM | 1996 | Leukemia1996，10，： | 1 |
| 19 | Periodontitis and atherosclerotic cardiovascular disease: Consensus report of the joint efp/aap workshop on periodontitis and systemic diseases 显示文摘 | Tonetti MS Van Dyke TE | 2013 | J Clin Periodontol2013，40，14： | 1 |
| 20 | U nila-teral multicystic dysplastic kidney:a combined pre-and postnatalass es sment显示文摘 | Van Eijk L Cohen-Overbeek TE Den-Hollander NS | 2002 | Ultrasound Obstet Gynecol2002，19，： | 1 |
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