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| 1 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 2 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | CD28/CTLA-4/B7 and CD40/CD40L costimulation and activation of regulatory T cells显示文摘Costimulatory signals are crucial for T cell activation. Attempts to block costimulatory pathways have been effective in preventing unwanted immune reactions. In particular, blocking the CD28/cytotoxic T lymphocyte antigen(CTLA)-4/B7 interaction(using CTLA-4Ig) and the CD40/CD40 L interaction(using anti-CD40 L antibodies) prevents T cell mediated autoimmune diseases, transplant rejection and graft vs host disease in experimental models. Moreover, CTLA-4Ig is in clinical use to treat rheumatoid arthritis(abatacept) and to prevent rejection of renal transplants(belatacept). Under certain experimental conditions, this treatment can even result in tolerance. Surprisingly, the underlying mechanisms of immune modulation are still not completely understood. We here discuss the evidence that costimulation blockade differentially affects effector T cells(Teff) and regulatory T cells(Treg). The latter are required to control inappropriate and unwanted immune responses, and their activity often contributes to tolerance induction and maintenance. Unfortunately, our knowledge on the costimulatory requirements of Treg cells is very limited. We therefore summarize the current understanding ofthe costimulatory requirements of Treg cells, and elaborate on the effect of anti-CD40 L antibody and CTLA-4Ig treatment on Treg cell activity. In this context, we point out that the outcome of a treatment aiming at blocking the CD28/CTLA-4/B7 costimulatory interaction can vary with dosing, timing and underlying immunopathology. | Isabel T Vogel Stefaan W Van Gool Jan L Ceuppens | 2014 | World Journal of Immunology2014，4，2： | 3 |
| 4 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 5 | Flow-Injection Chemiluminescence Determination of Chlorpromazine Hydrochloride Applying the Luminol-Hydrogen Peroxide-Chromium ( Ⅲ ) System 显示文摘 | Wang L Baeyens W R G Van Der Weken G | 2000 | Luminescence2000，15，： | 2 |
| 6 | A new technique of reversibly adsorbed phosphate显示文摘 | Fokkink L G J Van Reimsdijk W H | 1987 | Soil Sci Soc Am J1987，51，： | 1 |
| 7 | Overexpression of a novel Arabidopsis gene related to putative zinc-transporter genes from animals can lead to enhanced zinc resistance and accumulation显示文摘 | VAN DER ZAAL B J NEUTEBOOM L W PINAS J E | 1999 | Plant Physiology1999，119，： | 1 |
| 8 | Simultaneous nitrification and denitrification in aerobic chemostat culture of Thiosphaera patotropha显示文摘 | ROBERTSON L A VAN NIEL E W J TORREMANS R A M | 1988 | Applied Environmental Microbiology1988，54，11： | 1 |
| 9 | Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus显示文摘 | VAN GORP H VAN BREEDAM W DELPUTTE P L | 2008 | J Gen Virol2008，89，12： | 1 |
| 10 | Advanced anaerobic wastewater treatment in the near future显示文摘 | Lettinga G Field J Van Lier J B Zeeman G Pol L W H | 1997 | Wat Sci Technol1997，35，10： | 1 |
| 11 | Heuristic to control integrated multi-product multimachine production-inventory systems with job shop routings and stochastic arrival,set-up and processing times显示文摘 | Van Nyen P L M Bertrand J W M Van Ooijen H P G Vandaele N J A | 2005 | OR Spectrum2005，27，23： | 1 |
| 12 | The role of feed consumption and feed efficiency in copper-stimulated growth显示文摘 | ZHOU W KORNEGAY E T VAN L H | 1994 | J Ainm Sci1994，72，： | 1 |
| 13 | Dynamics of nitric oxide and nitrous oxide emissionduring full-scale reject water treatment显示文摘 | Kampschreur M J van der Star W R L Wielders H A | 2008 | Water Res2008，42，3： | 1 |
| 14 | Identification of pork quality parameters by proteomics 显示文摘 | van de Wiel D F M Zhang W L | 2007 | Meat Science2007，77，1： | 1 |
| 15 | Microarray analyses of gene expression during adventitious root development in Pinus contorta显示文摘 | Brinker M van Zyl L Liu W | 2004 | Plant Physiology2004，135，3： | 1 |
| 16 | On the approximation of solvent effects on conformation and dynamics of Cyclosporin:A by stochastic dynamics simulation techniques显示文摘 | Shi Y Y Wang L Van Gunsteren W F | 1988 | Mol Simul1988，1，： | 1 |
| 17 | A heterozygosity in the SOD1 gene is associated with familial and apparently sporadic amyotrophic lateral sclerosis显示文摘 | Robberecht W Aguirre T Van Den Bosch L | 1996 | Neurology1996，47，： | 1 |
| 18 | A prospective randomized EORTC intergroup phase 3 study comparing the complications of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma 显示文摘 | Van Poppel H Da Pozzo L Albrecht W | 2007 | Eur Urol2007，51，6： | 1 |
| 19 | A New Composite for External Reinforcement : Steel Cord Reinforced Polymer 显示文摘 | FIGEYS W SCHUEREMANS L VAN GEMERT D | 2008 | Construction and Building Materials2008，22，9： | 1 |
| 20 | Startup of reactors for anoxic ammonium oxidation: Experiences from the first full-scale ANAMMOX reactor in Rotterdam 显示文摘 | VAN DE Star W R L ABMA W R BLOMMERS D et al | 2007 | Water Research2007，41，18： | 1 |
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