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| 1 | Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets显示文摘 | Hommes D W Peppelenbosch M P van Deventer S J | 2003 | Gut2003，52，1： | 14 |
| 2 | WONCA研究论文摘要汇编——COPD第1秒用力呼气末容积/用力肺活量固定值与参考值下限的关系:基于人群的加拿大COPD队列研究报告显示文摘目的呼吸量测定的方法可以导致COPD的误诊,甚至造成不当治疗。本研究比较两种标准的临床指标的相关性,即第1秒用力呼气末容积/用力肺活量(FEV1/FVC)的固定值及其参考值下限。方法分析基于人群的加拿大COPD队列研究的数据,分析测量气流受限的呼吸量测定标准与患者报告的不良后果的关系,包括呼吸道症状、残疾、健康状况、病情加重、心血管疾病。用敏感性分析探索年龄及气流受限严重程度对上述指标相关性的影响。结果对4 882例40岁以上患者的数据进行分析。FEV1/FVC固定值测定的气流受限发生率为17%,参考值下限为11%。由FEV1/FVC固定值测定的气流受限的患者发生不良后果的可能性增高不明显;由FEV1/FVC固定值联合参考值下限测定为气流受限且患者FEV1低于预测值80%与发生不良后果的可能性更大。结论研究结果表明,单独使用FEV1/FVC固定值可能导致COPD的误诊。由FEV1/FVC固定值和参考值下限得出的诊断与低FEV1、临床后果有着密切关系。指南应考虑两种呼吸量测量法的异常,从而减少COPD的过度诊断。 | van Dijk W Tan W Li P 本刊编辑部 | 2015 | 中国全科医学2015，18，8： | 10 |
| 3 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 4 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 5 | Kinetics of CO2 with primary and secondary amines in aqueous solutions显示文摘 | Little R J Versteeg G F Van Swaaij W P M | 1992 | Chem Eng Sci1992，47，： | 3 |
| 6 | 帕克活性生物砂滤脱氮工艺的设计与运行显示文摘位于鹿特丹西部的De Groote Lucht污水厂的原处理工艺无法满足新的氮排放标准,因此进行了改扩建工程,增加了活性生物砂滤床作为三级处理工艺。改造后的处理系统既能达到很高的脱氮效率,又能较好地去除SS和COD,运行稳定,人工操作简单,可满足年平均总氮含量<10 mg/L的标准要求。 | Kramer J P Wouters J W Rosmalen P van | 2007 | 中国给水排水2007，23，6： | 3 |
| 7 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 8 | Authentication and authenticated key exchanges显示文摘 | Diffie W Van Oorschot P C Wiener M J | 1992 | Des Codes Cryptography1992，，2： | 2 |
| 9 | An airflow olfactometer for measuring olfactive responses of hymenopterous parasitoids and other small insects显示文摘 | VET W P van LENTEREN J C HEYMANS M | 1983 | Physidogical Entomology1983，8，： | 2 |
| 10 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 11 | Is tolerance to summer flooding correlated with distribution patterns in river floodplains? A comparative study of 20 terrestrial grassland species 显示文摘 | Van Eck W H J M Van de Steeg H M Blom C W P M De Kroon H | 2004 | Oikos2004，107，： | 1 |
| 12 | Interstitial radiation therapy for early-slagenasal vestibule cancer: A continuing quest for optimal tumor control and cosmesis显示文摘 | Levendag P C Nijdam W M van Moolenburgh S E | 2006 | Int Radiat Oncol Biol Phys2006，66，1： | 1 |
| 13 | Catalytic growth of macroscopic carbon nanofiber bodies with high bulk density and high mechanical strength显示文摘 | Lee M K van der Dillen A J van Geus J W Jong K P de Bitter J H | 2006 | Carbon2006，44，： | 1 |
| 14 | Molecular dynamics with coupling to an external bath显示文摘 | Berendsen H J C Postma J P M van Gunsteren W F | 1984 | Journal of Chemical Physics1984，81，8： | 1 |
| 15 | Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus显示文摘 | VAN GORP H VAN BREEDAM W DELPUTTE P L | 2008 | J Gen Virol2008，89，12： | 1 |
| 16 | Hierarchical crosstraining in work-in-process-constrained systems 显示文摘 | Gel E S Hopp W J Van Oyen M P | 2007 | lie Transactions2007，39，2： | 1 |
| 17 | Verfication of workflow task structures: a petri-net-based approach 显示文摘 | AALST van der W M P HOFSTEDE ter A H M | 2000 | Information Systems2000，25，1： | 1 |
| 18 | The African catfish,Clarias gariepinus,a model for the study of reproductive endocrinologyin teleosts显示文摘 | VAN OORDT P G W J GOOS H J Th | 1987 | Aquaculture1987，63，： | 1 |
| 19 | Ecological footprints of Benin, Bhutan, Costa Rica and the Netherlands 显示文摘 | van Vuuren D P Smeets E M W | 2000 | Ecological Economics2000，34，： | 1 |
| 20 | The use of SPECT and PET in routine clinical practice in epilepsy显示文摘 | Van Paesschen W Dupont P Sunaert S | 2007 | Curr Opin Neurol2007，20，2： | 1 |
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