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| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | Interaction between cisplatin and gemcitabine in vitro and in vivo 显示文摘 | Peters G J Bergman A M Ruiz van Haperen V W | 1995 | Semin Oncol1995，22，411： | 1 |
| 3 | Kinetic Study by Thermogravimetry显示文摘 | Van D W Herrden C V Hutjens F J | 1951 | Fuel1951，11，15： | 1 |
| 4 | Nanoparticle-filled silane films as chromate replacements for aluminium alloys显示文摘 | Palanivel V Zhu D Van Ooij W J | 2003 | Prog Org Coat2003，47，： | 1 |
| 5 | Randomized phase II comparison of dose-intense gem-citabine:thirty-minute infusion and fixed dose rate in-fusion in patients with pancreatic adenocarcinoma显示文摘 | Tempero M Plunkett W Ruiz Van Haperen V | 2003 | JClin Oncol2003，21，34： | 1 |
| 6 | Supply chain management in food chains:Im proving performance by reducing uncertainty显示文摘 | VAN D V BEULENS A J M WIT W D | 1998 | International Transactions in Operational Research1998，5，6： | 1 |
| 7 | Synergistic interaction between ciaplatin and gemcitabine in vitro 显示文摘 | Bergman A M Ruiz van Haperen V W Veerman G | 1996 | Clin Cancer Res1996，2，3： | 1 |
| 8 | Silane based metal pretreatments as alternatives to chrornating显示文摘 | Subramanian V Van Ooij W J | 1999 | Surf Eng1999，15，2： | 1 |
| 9 | Crystal structureof an ACh-binding protein reveals the ligandbinding domain ofnicotinic receptors显示文摘 | Brejc K van Dijk W J Klaassen R V | 2001 | Nature2001，411，： | 1 |
| 10 | Effect of nitrogen concentration on fructan metabolizing enzymes in young chicory plants (Cichorium intybus)显示文摘 | Van den Ende W Roover J D Laere A V | 1999 | Physiologia Plantarum1999，105，： | 1 |
| 11 | The Reverse Supply Chain显示文摘 | Guide J V D Luk N Van W | 2002 | Harvard Business Review2002，80，2： | 1 |
| 12 | Silane based metal pretreatments as alternatives to chromating: Shortlisted 显示文摘 | SUBRAMANIAN V VAN OOIJ W J | 1999 | Surface Engineering1999，15，2： | 1 |
| 13 | Detection of cesarean scars by transvaginal ultrasound 显示文摘 | Armstrong V Hansen W F Van Voorhis B J | 2003 | Obstet Gyneeol2003，101，1： | 1 |
| 14 | Perceived influence in groups over time: How associations with personality and cognitive ability can change over time显示文摘 | Deuling J K Denissen J J A van Zalk M Meeus W & Aken M v | 2011 | Journal of Research in Personality2011，45，6： | 1 |
| 15 | Nonlinear H∞ almost disturbance decoupling 显示文摘 | Marino R Respondek W Van der Schaft A V | 1994 | Systems & Lett1994，23，15： | 1 |
| 16 | Randomized pahse 2 comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma显示文摘 | Tempero M Plunkett W Ruiz Van Haperen V | 2003 | J clin oncol2003，21，18： | 1 |
| 17 | The challenge of close&loop supply chain 显示文摘 | GUIDE V D R HARRISON T P VAN W N | 2003 | Interfaces2003，33，6： | 1 |
| 18 | A structural model of pestivirus E^ms based on disulfide bond connectivity and homology modeling revealsan extremely rare vicinal disulfide显示文摘 | Langedijk J P M van V P A Schaaper W M M | 2002 | Virology2002，76，10： | 1 |
| 19 | Genetic parameters of health disorders,and relationships with 305-day milk yield and conformation traits of registered Holstein cows显示文摘 | Van Dorp R T E Dekkers J V M Martin S W | 1998 | Journal of Dairy Science1998，81，： | 1 |
| 20 | Sulfidation and thiophene hydrodesulfurizationactivity of nickel tungsten sulfide model catalysts, prepared without and with chelating agents 显示文摘 | KISHAN G COULIER L de BEER V H J van VEEN J A R RIET J W | 2000 | J Catul2000，196，1： | 1 |
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