|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy显示文摘AIM: To examine DNA methylation profiles in a longitudinal comparison of pre-diabetes mellitus(Pre-DM) subjects who transitioned to type 2 diabetes mellitus(T2DM).METHODS: We performed DNA methylation study in bisulphite converted DNA from Pre-DM(n = 11) at baseline and at their transition to T2 DM using Illumina Infinium Human Methylation27 Bead Chip, that enables the query of 27578 individual cytosines at Cp G loci throughout the genome, which are focused on the promoter regions of 14495 genes.RESULTS: There were 694 Cp G sites hypomethylated and 174 Cp G sites hypermethylated in progression from Pre-DM to T2 DM, representing putative genes involved in glucose and fructose metabolism, inflammation, oxidative and mitochondrial stress, and fatty acid metabolism. These results suggest that this high throughput platform is able to identify hundreds of prospective Cp G sites associated with diverse genes that may reflect differences in Pre-DM compared with T2 DM. In addition, there were Cp G hypomethylation changes associated with a number of genes that may be associated with development of complications of diabetes, such as nephropathy. These hypomethylation changes were observed in all of the subjects.CONCLUSION: These data suggest that some epigenomic changes that may be involved in the progression of diabetes and/or the development of complications may be apparent at the Pre-DM state or during the transition to diabetes. Hypomethylation of a number of genes related to kidney function may be an early marker for developing diabetic nephropathy. | Thomas A Vander Jagt Monica H Neugebauer Marilee Morgan Donald W Bowden Vallabh O Shah | 2015 | World Journal of Diabetes2015，6，9： | 5 |
| 2 | Renal artery denervation suppresses intractable ventricular arrhythmia in patients with left heart thrombosis显示文摘Transcutaneous renal artery denervation (RND) has beeninitially developed for destruction of efferent nerve fireswith luminal delivery of radiofrequency or ultrasonic energyaiming blood pressure reduction in patients with refractoryhypertension. However, other positive results of RNDwere described afterwards, and they include suppression ofatrial fibrillation and ventricular tachycardia (VT) storm. | Marianna A Vander Petr A Fedotov Tamara A Lyubimtseva Maria A Bortsova Maria Yu Simikova Dmitry S Lebedev Evgeny N Mikhaylov | 2017 | Journal of Geriatric Cardiology2017，14，9： | 2 |
| 3 | The isothermal austenite-ferrite transformation in some deformed vanadium steels显示文摘 | M J Crooks A J Garratt-Reed J B Vander Sande W S Owen | 1982 | Metallurgical Transactions A1982，，8： | 2 |
| 4 | Mimicking rubella virus particles by using recombinant envelope glyeoproteins and liposomes显示文摘 | Orellana A Mottershead D Vander linden I | 1999 | J Biotechnol1999，75，23： | 1 |
| 5 | Isopentenyl diphosphate isomerase and prenyltransferase activities in rubiaceous and apocynaceous cultures显示文摘 | Ramos V A C Vander H R Verpoorte R | 1998 | Phytochemistry1998，48，： | 1 |
| 6 | The role of seed banks in the vegetation dynamics of prairie glacial marshes显示文摘 | VANDER A | 1978 | Ecology1978，59，3： | 1 |
| 7 | Simple Heuristics for Push and Pull Remanufacturing Policies 显示文摘 | Erwin A Vander Laan Ruud H Teunter | 2006 | European Journal of Operational Research2006，，175： | 1 |
| 8 | Uncertainty calculations for the preparation of primary gas mixtures 1 Gravimetry 显示文摘 | Alink A Vander Veen A M H | 2000 | Metrologia2000，37，： | 1 |
| 9 | Breast cancer resistance protein (BCRP/ABCG2) is expressed by progenitor cells/reactive ductules and hepatocytes and its expression pattern is influenced by disease etiology and species type: possible functional consequences 显示文摘 | Vander Borght S Libbrecht L Katoonizadeh A | 2006 | J Histochem Cytochem2006，54，9： | 1 |
| 10 | The coupled problem in electromagnetic ac contactors显示文摘 | Abdul-Rahman A Mary J Vander H | 1997 | IEEE Transactions on Magnetics1997，33，3： | 1 |
| 11 | Global burden of blood-pressure-related disease: 2001 显示文摘 | Lawes CM Vander Hoom S Rodgers A | 2008 | Lancet2008，371，9623： | 1 |
| 12 | Preparation and chemical composition of difluorodiphe nyltrichloroethane显示文摘 | Leon Bradlow H Vander Werf Calvin A | 1947 | J Am Chem Soc1947，69，66： | 1 |
| 13 | The prevalence helicobacter pylori serum antibodies in children with recurrent abdominal pain显示文摘 | Vander MeerB Forget P etal | 1992 | Eur J pediatr1992，151，： | 1 |
| 14 | Structural protein requirements in equine arteritis virus assembly显示文摘 | Wieringa R de Vries A A vander Meulen J | 2004 | J Virol2004，78，13： | 1 |
| 15 | Effect of lauric acid and coconut oil on ruminal fermentation, digestion, ammonia losses from ma- nure, and milk fatty acid composition in lactating cows显示文摘 | HRISTOV A N VANDER POL M AGLE M | 2009 | Journal of Dairy Science2009，92，11： | 1 |
| 16 | Evaluation of diagnostic criteria for ankylosing spondylitis:A proposal for modification of the New York criteria显示文摘 | Vander L S Valkenburg H A Cats A | 1984 | Athritis Rheum1984，27，： | 1 |
| 17 | The prev- alence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombi- nant human GH显示文摘 | Vander Klaauw A A Biermasz N R Feskens E J | 2007 | European Journal of Endocrinology2007，156，： | 1 |
| 18 | Mossbauer study of several ferromagnetic spinals 显示文摘 | Sawatzky G A Vander W F Morrish A H | 1969 | Phys Rev1969，187，： | 1 |
| 19 | The role of seed banks in the vegetation dynamics of prairie glacial marshes显示文摘 | VANDER V A G DAVIS C B | 1978 | Ecology1978，59，： | 1 |
| 20 | Correction of lens aberrations by means of holograms显示文摘 | Upatnieks J Vander L A Leith E | | 0，，04： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员