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| 1 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 2 | 2013年美国心脏病学会/美国心脏协会胆固醇管理指南在美国心脏病学实践中的应用显示文摘2013年美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)胆固醇管理指南建议在符合治疗标准的患者中采用中等强度至高强度他汀类药物治疗。该研究的目的在于审查2013年ACC/AHA指南在美国心脏病学实践中的应用情况。 | 刘莉 叶鹏 Pokharel Y Tang F Jones PG Nambi V Bittner VA Hira RS Nasir K Chan PS Maddox TM Oetgen WJ Heidenreich PA Borden WB Spertus JA Petersen LA Ballantyne CM Virani SS | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 3 | Haploinsufficiency of delta- like 4 ligand results in embryonic lethality due to ma:or defects in arterial and vascular development显示文摘 | Gale N W Dominguez M G Noguera I Pan L Hughes V Va]enzuela D M | 2004 | Proc Natl Acad Sci USA2004，101，15： | 1 |
| 4 | Afatinib versus placebo for patients with advanced ,metastatic non-small- cell lung cancer after failure of erlotinib,gefitinib,or both,and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial 显示文摘 | Miller VA Hirsh V Cadranel J | 2012 | Lancet Oncol2012，13，5： | 1 |
| 5 | Ozone acting on human blood yields a hormetic dose-response relationship 显示文摘 | Bocci VA Zanardi I Travagli V | 2011 | J Transl Med2011，17，9： | 1 |
| 6 | Electrodynamic characteristics of coaxial-radial line slow-wave structure显示文摘 | Glushkov A R Mukhin S V Solntsev VA | 1993 | Journal of Communications Technology and Electronic1993，38，2： | 1 |
| 7 | Diffuse 3JI lung uptake in bronchiectasis:a potential pitfall in the follow-up of differentiated thyroid carcinoma显示文摘 | Triggiani V Moschetta M Giagulli VA | 2012 | Thyroid2012，22，12： | 1 |
| 8 | Properties of bitumens modified by ther- moplastic elastomers显示文摘 | KHAKIMULLIN Y N KIMELBLAT V I CHEBOTARE- VA I G | 2000 | Mechanics of Composite Mate- rials2000，36，5： | 1 |
| 9 | Effective refactive index and composition of oxidized porous silicon films 显示文摘 | Astrova E V Tolmachev VA | 2002 | Materials Science and Engineering2002，69，70： | 1 |
| 10 | New approaches to typing and identification of bacteria using the 16S-23S rDNA spacer region显示文摘 | Gurtler V VA Stanisich | 1996 | Microbiology1996，142，1： | 1 |
| 11 | 133-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2 + current 显示文摘 | Skeberdis VA Gendviliene V Zablockaite D | 2008 | J Clin Invest2008，118，9： | 1 |
| 12 | Clinical, electrophysiological and brain imaging features during recurrent ictal cortical blindness associated with chronic liver failure 显示文摘 | Vanpesch V Hemalsteen D nrijckevororsel VA | 2006 | Acta Neurol Belg2006，106，： | 1 |
| 13 | Afatinib versus placebo far patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefiinib, or both, and one or two lines of chemo- therapy ( LUX-Lung 1 ) : a phase 2b/3 randomised trial显示文摘 | Miller VA Hirsh V Cadranel J | 2012 | Lancet Onco12012，13，5： | 1 |
| 14 | Comparision of ultrasound biomicroscopic and gonioscopic features of angle In pre & post laser peripheral iridotomy patients of primary angle closure glaucoma显示文摘 | Prajapati VA Rana V Mansuri MN | 2013 | Delhi Journal of Oph-thalmology2013，23，： | 1 |
| 15 | Solid pseudopapil- lary neoplasm of the ovary: a report of 3 primary ovari- an tumors resembling those of the pancreas显示文摘 | Deshpande V O Young RH | 2010 | Am J Surg Pathol2010，34，10： | 1 |
| 16 | Initial assessment of the acceptability of a Push?Pull Aedes aegypti control strategy in Iquitos, Peru and Kanchanaburi,Thailand显示文摘 | Paz-Soldan VA Plasai V Morrison AC | 2011 | Am J Trop Med Hyg2011，84，2： | 1 |
| 17 | Malignancies after renal transplantation during 33 years at a single center显示文摘 | Gyula Végs? Maria Tóth Márta Hídvégi éva Toronyi Robert Mlanger Elek Dinya András Tóth Ferenc Perner Jen? Járay | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 18 | Screening of FSH receptor gene in argentine women with premature ovarian failure (POF) 显示文摘 | Sundblad V Chiauzzi VA Escobar ME | 2004 | Mol Cell Endocrinol2004，222，12： | 1 |
| 19 | Insect immunity:evolutionary roots of the mammalian innate immune system显示文摘 | Péter V (E)va K | 1998 | Immunol Lett1998，62，： | 1 |
| 20 | A major surface protein on group A streptococci is a glyceraldehyde-3-phosphate-dehydrogenase with multiple binding activity显示文摘 | Pancholi V Fischetti VA | 1992 | Exp Med1992，，176： | 1 |
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