|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gallstone ileus:One-stage surgery in a patient with intermittent obstruction显示文摘Gallstone ileus, an uncommon complication of cholelithiasis, is described as a mechanical intestinal obstruction due to impaction of one or more large gallstones within the gastrointestinal tract. The clinical presentation is variable, depending on the site of obstruction, manifested as acute, intermittent or chronic episodes. A 51-year-old female patient was referred to our hospital with 3 events of intestinal obstruction during the previous 7 d. At admission, there were clinical signs of intestinal obstruction; abdominal film demonstrated dilated bowel loops, air-fluid levels and a vague image of a stone in the inferior left quadrant. Once stabilized, a laparotomy was performed. Surgical findings were distention of the jejunum and ileum proximal to a palpable stone in the ileum as well as gallstones and a cholecystoduodenal fistula in the gallbladder. An enterolithotomy, repair of the cholecystoduodenal fistula and cholecystectomy were performed. The postoperative course was uneventful. There is no uniform surgical procedure for this disease. When the patient is too ill or when biliary surgery is not advisable, an enterolithotomy is the best option. The one-stage procedure should be the offered to adequately stabilized patients when local and general conditions, such as good cardiorespiratory and metabolic reserve permit a more prolonged surgical procedure. | Carlos M Nuo-Guzmán José Arróniz-Jáuregui Pável A Moreno-Pérez édgar A Chávez-Solís Nereida Esparza-Arias Cuauhtémoc I Hernández-González | 2010 | World Journal of Gastrointestinal Surgery2010，2，5： | 5 |
| 2 | Timing, method and discontinuation of hydrocortisone administration for septic shock patients显示文摘AIM To characterize the prescribing patterns for hydrocortisone for patients with septic shock and perform an exploratory analysis in order to identify the variables associated with better outcomes.METHODS This prospective cohort study included 59 patients with septic shock who received stress-dose hydrocortisone.It was performed at 2 critical care units in academic hospitals from June 1st, 2015, to July 31 st, 2016. Demographic data, comorbidities, medical management details, adverse effects related to corticosteroids, and outcomes were collected after the critical care physician indicated initiation of hydrocortisone. Univariate comparison between continuous and bolus administration of hydrocortisone was performed, including multivariate analysis, as well as Kaplan-Meier analysis to compare the proportion of shock reversal at 7 d after presentation. Receiver operating characteristic(ROC) curves determined the best cut-off criteria for initiation of hydrocortisone associated with the highest probability of shock reversal. We addressed the effects of the taper strategy for discontinuation of hydrocortisone, noting risk of shock relapse and adverse effects.RESULTS All-cause 30-d mortality was 42%. Hydrocortisone was administered as a continuous infusion in 54.2% of patients; time to reversal of shock was 49 h longer in patients who were given a bolus administration [59 h(range, 47.5-90.5) vs 108 h(range, 63.2-189); P = 0.001]. The maximal dose of norepinephrine after initiation of hydrocortisone was lower in patients on continuous infusion [0.19 μg/kg per minute(range, 0.11-0.28 μg)] compared with patients who were given bolus [0.34 μg/kg per minute(range, 0.16-0.49); P = 0.004]. Kaplan-Meier analysis revealed a higher proportion of shock reversal at 7 d in patients with continuous infusion compared to those given bolus(83% vs 63%; P = 0.004). There was a good correlation between time to initiation of hydrocortisone and time to reversal of shock(r = 0.80; P < 0.0001); ROC curve analysis revealed that the best criteria for prediction of shock reversal was a time to initiation of hydrocortisone of ≤ 13 h after administration of norepinephrine, with an area under the curve of 0.81(P < 0.001). The maximal dose of norepinephrine at initiation of hydrocortisone with the highest association with shock reversal was ≤ 0.28 μg/kg per minute, with an area under the curve of 0.75(P = 0.0002). On a logistic regression model, hydrocortisone taper was not associated with a lower risk of shock relapse(RR = 1.29; P = 0.17) but was related to a higher probability of hyperglycemia [odds ratio(OR), 5.3; P = 0.04] and hypokalemia(OR = 10.6; P = 0.01). CONCLUSION Continuous infusion of hydrocortisone could hasten the resolution of septic shock compared to bolus administration. Earlier initiation corresponds with a higher probability of shock reversal. Tapering strategy is unnecessary. | Miguel A Ibarra-Estrada Quetzalcóatl Chávez-Pe?a Claudia I Reynoso-Estrella Jorge Rios-Zerme?o Pável E Aguilera-González Miguel A García-Soto Guadalupe Aguirre-Avalos | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 3 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 4 | The selection and properties of Penicillium verruculosum mutants with enhanced production of cellulases and xylanases 显示文摘 | Soloveva I V Okunev O N Vel'kov V V | 2005 | Microbiology2005，74，2： | 1 |
| 5 | optimi- zing electromagnetic flowmeter coils显示文摘 | VEL'T I D MUSHKIN A M SYCHEV G I | 2003 | Measurement Techniques2003，46，2： | 1 |
| 6 | L-2-hydroxyglutaric aciduria in a patient with Klinefelter syndrome显示文摘 | Pascual-Castroviejo I Pascual-Pascual S I Velázquez Fragua R | 2005 | Neurologia2005，20，： | 1 |
| 7 | Otologic disease in turnersyndrome显示文摘 | Dhooge I J De Vel E Verhoye C | 2005 | Otol Neurotol2005，26，2： | 1 |
| 8 | Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity显示文摘 | Vel 6 zquez-L 6 pez L1 Santiago-D I az G Nava-Hern 6 ndez J | 2014 | BMC Pediatr2014，14，： | 1 |
| 9 | The Selection and Properties of Penicillium verruculosum Mutants with Enhanced Produetion of Cellulases and Xylanases 显示文摘 | I V Soloeva O N Okunev V V Vel' kov | 2005 | Microbiology2005，74，： | 1 |
| 10 | A new approach for separating low-molecular-weight RNA molecules by staircase electrophoresis in non-sequencing gels显示文摘 | ENCARNA VEL(A)ZQUEZ RA U1 RIVAS MAR(I)A DEL VILLAR | 2006 | Electrophoresis2006，27，： | 1 |
| 11 | Kinetic characterization of the rotenone-insensitive internal NADH:ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae显示文摘 | Velázquez I Pardo JP | | 0，，1： | 1 |
| 12 | Removal and transformation of recal- citrant organic matter from stabihzed salineandfill eachates by coagulation- ozonation coupling processes 显示文摘 | RAMIREZ I M VEL SQUEZ M T O | 2004 | Water research2004，38，： | 1 |
| 13 | Differential impact of REM sleep deprivation on cytoskeletal proteins of brain regions involved in sleep regulation显示文摘 | Rodríguez-Vázquez J Camacho-Arroyo I Velázquez-Moctezuma J | | 0，，03： | 1 |
| 14 | Microstructural and chemical changes at the Ni/YSZ interface 显示文摘 | PRIMDAHL S CHORKENDORFF I | 2001 | Solid State Ionics2001，144，： | 1 |
| 15 | The selection and properties of Penicillium verruculosum mutants with enhanced production of cellulases and xylanases显示文摘 | Solodeva I V Okunev O N Vel'kov V V | 2005 | Microbiology2005，74，2： | 1 |
| 16 | Steroid metabolism in theca externa cells from preovulatory follicles of domestic hen (Gallus domesticus)显示文摘 | Rodr i guez-Maldonado E Vel a zquez P N Ju a rez-Oropeza M A et ol | 1996 | Gen Comp Endocrinol1996，101，： | 1 |
| 17 | Folliclestimulating hormone regulates steroidogenic enzymes in cultured cells of the chick embryo ovary显示文摘 | Gómez Y Velázquez P N Peralta-Delgado I | 2001 | Gen Comp Endocrinol2001，121，： | 1 |
| 18 | Direct contact membrane distillation of humic acid solutions显示文摘 | Khayet M Velázquez A Mengual J I | | 0，，： | 1 |
| 19 | Load testing and GPR assessment for concrete bridges on military installations显示文摘 | Varela Ortz W Lugo Cintrón G Y Velázqucz G I | | 0，，09： | 1 |
| 20 | Otologic disease in turner syndrome显示文摘 | Dhooge I J De Vel E Verhoye C | 2005 | Otol Neurotol2005，26，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员