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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet . 2009 (9688)2009，，9688： | 4 |
| 3 | Extended lymph node dissection for gastric cancer:who may benefit?Final results of the randomized Dutch gastric cancer group trial显示文摘 | Hartgrink HH van de Velde C J Putter H | | 0，，11： | 3 |
| 4 | Neo-adjuvant chemotherapy for operable gastric cancer: long term results of the Dutch randomised FAMTX trial 1显示文摘 | H.H Hartgrink C.J.H van de Velde H Putter I Songun M.E.T Tesselaar E.Klein Kranenbarg J.E de Vries J.A Wils J van der Bijl J.H.J.M van Krieken | 2004 | European Journal of Surgical Oncology2004，，6： | 2 |
| 5 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet2009，，9688： | 2 |
| 6 | The stimulation of cell proliferation by quercetin is mediates by the estrogen receptor显示文摘 | Vander Woude H Ter Veld MG Jacobs N | 2005 | Mol Nutr Food Res2005，49，8： | 1 |
| 7 | Evolution of soil chemical properties in the past 50 years in the Tai Lake Region, China显示文摘 | Wang H Dong YH Li DC Velde B An Q Guo ZX Zuo QD | 2008 | Soil and Tillage Research2008，100，12： | 1 |
| 8 | Extended lymph node dissection for gastric cancer:who may benefit? Final results of the randomized Dutch gastric cancer group trial显示文摘 | Hartgrink HH van de Velde C J Putter H | 2004 | J Clini On- col2004，22，11： | 1 |
| 9 | Identification and charac-terization of the cps locus of Streptococcus suis serotype 2: the capsulcprotects against phagocytosis and is an important virulence factor显示文摘 | Smith H E Damman M van der Velde J | 1999 | Infect Immun1999，67，： | 1 |
| 10 | Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treat- ment of Cancer trial 10902 显示文摘 | van der HAGE J A van de VELDE C J H JULIEN J P | 2001 | J Clin Oneol2001，19，22： | 1 |
| 11 | Psychological contract breach and job attitudes:A meta-analysis of age as a moderator 显示文摘 | Bal P M De Lange A H Jansen P G W Der Velde M E G V | 2008 | Journal of Vocational Behavior2008，72，1： | 1 |
| 12 | Ammonia emission and its reduction from cubicle houses by flushing显示文摘 | KroodsmaW Huis J W H in 't Veld J W H | 1993 | Livestock Production Science1993，35，： | 1 |
| 13 | In-vitro matured metaphase-I oocytes have a lower fertilization rate but similar embryo quality as mature metaphase-II oocytes after intracytoplasmic sperm injection显示文摘 | DeVos A Van de Velde H Joris H | 1999 | Hum Reprod1999，14，7： | 1 |
| 14 | Sertoli cell-condi- tioned medium induces germ cell differentiation in human embryon- ic stem cells 显示文摘 | Geens M Sermon KD Van de Velde H et at | 2011 | J Assist Reprod Genet2011，28，5： | 1 |
| 15 | The mechanism behind microstmeture formation in mixed whey protein-polysaccharide cold- set gels 显示文摘 | de Jong S Klok H J van de Velde F | 2009 | Food Hydroeolloids2009，23，： | 1 |
| 16 | Micrometastasis and survival in stage Ⅱ colorectal cancer显示文摘 | Leifers G J Cleton Jansen A M Van de Velde C J H | 1998 | N Engl J Med1998，339，4： | 1 |
| 17 | A one-step synthesis of a deuterated paclitaxel analogue: 10-Deacetoxy-(10alpha-2H) paclitaxel 显示文摘 | DUTTA D HADD H VANDER VELDE D G | 1999 | Bioorganic&Medicinal Chemistry Letters1999，9，23： | 1 |
| 18 | A testbed project for DICOM images and waveforms integration显示文摘 | van der Velde ET Oon H Kleijhorst A | 1998 | IEEE Comput Cardiol1998，25，： | 1 |
| 19 | Aerobic domestic waste water treatment in a Pilot Plant with complete sludge retention by corss-flow filtration 显示文摘 | Muller E B Stouthamer A H van V- veld H W | 1995 | War Res1995，29，4： | 1 |
| 20 | The effects of extreme water level fluctuations on the wetland vegetation of a nymphaeid-dominated oxbow lake in The Netberlands显示文摘 | BROCK T C M VELDE VAN DER G STEEG VAN DE H M | 1987 | Arch Hydrobiologia1987，，27： | 1 |
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