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| 1 | Software for automated classification of probe-based confocal laser endomicroscopy videos of colorectal polyps显示文摘AIM:To support probe-based confocal laser endomi-croscopy (pCLE) diagnosis by designing software for the automated classification of colonic polyps. METHODS:Intravenous fluorescein pCLE imaging of colorectal lesions was performed on patients under-going screening and surveillance colonoscopies, followed by polypectomies. All resected specimens were reviewed by a reference gastrointestinal pathologist blinded to pCLE information. Histopathology was used as the criterion standard for the differentiation between neoplastic and non-neoplastic lesions. The pCLE video sequences, recorded for each polyp, were analyzed off-line by 2 expert endoscopists who were blinded to the endoscopic characteristics and histopathology. These pCLE videos, along with their histopathology diagnosis, were used to train the automated classification software which is a content-based image retrieval technique followed by k-nearest neighbor classification. The performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists was compared with that of automated pCLE software classification. All evaluations were performed using leave-one-patient- out cross-validation to avoid bias. RESULTS:Colorectal lesions (135) were imaged in 71 patients. Based on histopathology, 93 of these 135 lesions were neoplastic and 42 were non-neoplastic. The study found no statistical significance for the difference between the performance of automated pCLE software classification (accuracy 89.6%, sensitivity 92.5%, specificity 83.3%, using leave-one-patient-out cross-validation) and the performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists (accuracy 89.6%, sensitivity 91.4%, specificity 85.7%). There was very low power (< 6%) to detect the observed differences. The 95% confidence intervals for equivalence testing were:-0.073 to 0.073 for accuracy, -0.068 to 0.089 for sensitivity and -0.18 to 0.13 for specificity. The classification software proposed in this study is not a 'black box' but an informative tool based on the query by example model that produces, as intermediate results, visually similar annotated videos that are directly interpretable by the endoscopist. CONCLUSION:The proposed software for automated classification of pCLE videos of colonic polyps achieves high performance, comparable to that of off-line diagnosis of pCLE videos established by expert endoscopists. | Barbara André Tom Vercauteren Anna M Buchner Murli Krishna Nicholas Ayache Michael B Wallace | 2012 | World Journal of Gastroenterology2012，18，39： | 5 |
| 2 | Improvement of Peripheral Endothelial Dysfunction by Protein Tyrosine Phosphatase Inhibitors in Heart Failure显示文摘 | Vercauteren M Remy E Devaux C | 2006 | Circulation2006，114，： | 1 |
| 3 | Effect of immunosuppression on damage,leukocyte infiltration,and regeneration after severe warm ischemia/reperfusion renal injury显示文摘 | Ysebaert D K De Greef K E Vercauteren S R | 2003 | Kidney Int2003，64，3： | 1 |
| 4 | Phenylpropanoids from Leaves of Juniperus phoenicea 显示文摘 | Comte G Vercauteren J Chulia A J | 1997 | Phytochemistry1997，45，8： | 1 |
| 5 | Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice显示文摘 | Lacek K Vercauteren K Grzyb K Naddeo M Verhoye L Slowikowski M P Fafi-Kremer S Patel A H Baumert T F Folgori A Leroux-Roels G Cortese R Meuleman P Nicosia A | 2012 | J Hepatol2012，57，1： | 1 |
| 6 | The incidence of muhidrug and full class resistance in HIV 1 infected patients is decreasing over time (2001-2006) in Portugal显示文摘 | Vercauteren J Deforche K Theys K | 2008 | Retrovir ology2008，5，： | 1 |
| 7 | Combined continuous spinal-epidural anaesthesia with a single interspace, double-catheter technique显示文摘 | Vercauteren MP Geernaert K Vandeput DM | 1993 | Anaesthesia1993，48，： | 1 |
| 8 | PGC-l-related coactiva- tor complexes with HCF-1 and NRF-2 beta in mediating NRF-2 (GABP)-dependent respiratory gene expression 显示文摘 | Vercauteren K Gleyzer N Scarpulla RC | 2008 | J Biol Chem2008，283，12： | 1 |
| 9 | Prevention of hypotension by a single 5 mg dose of ephedrine during small-dose spinal anesthesia in prehydrated cesarean delivery patients 显示文摘 | Vercauteren M P Coppejans H C Hoffmann V H | 2000 | Anesth Analg2000，90，2： | 1 |
| 10 | H-MOR: Density functional investigation for the relative strength of Brnsted acid sites and dynamics simulation of NH3 protonation-deprotonation显示文摘 | ELANANY M VERCAUTEREN D P KOYAMA M KUBO M SELVAM P BROCLAWIK E MIYAMOTO A | 2006 | J Mol Catal A: Chem2006，243，1： | 1 |
| 11 | Diffeomorphic Demons : efficient non -parametric image registration 显示文摘 | VERCAUTEREN T PENNEC X PERCHANT A | 2009 | Neuroimage2009，45，1： | 1 |
| 12 | Interaction between the respiratory burst activity of neutrophil leukocytes and experimentall induced Escherichia coli mastitis in cows显示文摘 | Hcyneman R C Burvenich R Vercauteren | 1990 | Dairy Science1990，73，： | 1 |
| 13 | Pregnancy and Takayasu' s arteritis of the pulmonary artery 显示文摘 | Jacquemyn Y Vercauteren M | 2005 | J Obstet Gynaecol2005，25，1： | 1 |
| 14 | Relating increasing hantavirus incidences to the changing climate: the mast connection显示文摘 | Clement J Vercauteren J Verstraeten WW | 2009 | Int J Health Geogr2009，8，： | 1 |
| 15 | In vivo imaging of the bronchial wall microstructure using fibered confocal fluorescence microscopy 显示文摘 | Thiberville L Moreno-Swirc S Vercauteren T | 2007 | Am J Respir Crit Care Med2007，175，1： | 1 |
| 16 | Protective Action of Resveratrol in Human Skin: Possible Involvement of Specific Receptor Binding Sites显示文摘 | Bastianetto S DY Duranton A Vercauteren F | 2010 | PLoS One2010，5，12： | 1 |
| 17 | Fetal heart rate abnormalities after regional analgesia for labor pain:the effect of intrathecal opioids显示文摘 | Van de Velde M Vercauteren M Vandermeersch E | 2001 | Reg Anesth Pain Med2001，26，3： | 1 |
| 18 | Fetal heart rate abnormalities after regional analgesia for labor pain: the effect of intrathecal opioids显示文摘 | van de Velde M Vercauteren M Vandermeersch E | 2001 | Reg Anesth Pain Med2001，26，3： | 1 |
| 19 | Identification and kinetics of leukocytes after severe ischaemia/reperfusion renal injury显示文摘 | Ysebaert DK De Greef KE Vercauteren SR | 2000 | Nephrol Dial Transplant2000，15，10： | 1 |
| 20 | The Eta Pairing Revisited显示文摘 | Hess F Smart N Vercauteren F | 2006 | IEEE Transactions on Information Theory2006，52，10： | 1 |
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