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| 1 | Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia显示文摘Cervical cancer is a worldwide disease that constitutes a significant public health problem, especially in developing countries, not only due to its high incidence but also because the most affected population comprises women who belong to marginalized socio-economic classes. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. Human Papillomavirus(HPV) has several mechanisms for avoiding the immune system: it down-regulates the expression of interferon and upregulates interleukin(IL)-10and transforming growth factor(TGF)-β1 to produce a local immunosuppressive environment, which, along with altered tumor surface antigens, forms an immunosuppressive network that inhibits the antitumor immune response. In this review we analyzed the available data on several deregulated cellular immune functions in patients with NIC Ⅰ, NIC Ⅱ and NIC Ⅲ and cervical cancer. The effects of immunosuppressive cytokines on innate immune response, T-cell activation and cellular factors that promote tumor cell proliferation in cervical cancer patients are summarized. We discuss the functional consequences of HPV E2, E6, and E7 protein interactions with IL-10 and TGF-β1 promoters in the induction of these cytokines and postulate its effect on the cellular immune response in squamous intraepithelial cervical lesions and cervical cancer patients. This review provides a comprehensive picture of the immunological functions of IL-10 and TGF-β1 in response to HPV in humans. | Kirvis Torres-Poveda Margarita Bahena-Román Claudia Madrid-González Ana I Burguete-García Víctor Hugo Bermúdez-Morales Oscar Peralta-Zaragoza Vicente Madrid-Marina | 2014 | World Journal of Clinical Oncology2014，5，4： | 21 |
| 2 | Pleiotropic effects of lactate dehydrogenase inactivationin Lactobacillus casei显示文摘 | María J José L G Vicente M Gaspar P | 2005 | Research in Microbiology2005，156，： | 1 |
| 3 | Chattering-free sliding mode control for a class of nonlinear mechanical systems显示文摘 | Vicente P V Gerd H | 2001 | International Journal of Robust and Non-linear Control2001，11，12： | 1 |
| 4 | Acid activation of a palygorskite with HC1: de-velopment of physico-chemical? textural and surface proper-ties 显示文摘 | Suarez Barrios M Flores Gonzalez L V Vicente RodriguezM A | 1995 | Applied Clay Science1995，10，3： | 1 |
| 5 | Effects of dexmedetomide fentanyl infusion on blood pressure and heart rate during cardiac surgery in children显示文摘 | KLAMT J G ANDRADE VICENTE W V GARCIA L V | | 0，，08： | 1 |
| 6 | Corporate so-cial responsibility, firm value and financial performance inBrazil显示文摘 | VICENTE L C FREIRE F S FELIPE C V | 2011 | Social Responsibility Journal2011，7，2： | 1 |
| 7 | Synergistic effect of diosmin and interferon-a on metastatic pulmonary melanoma显示文摘 | Alvarez N Vicente V Martinez C | 2009 | Cancer Biother Radiopharm2009，24，3： | 1 |
| 8 | Chattering-free sliding mode control for a class of nonlinear mechanical systems显示文摘 | VICENTE P V GERDH | | 0，，12： | 1 |
| 9 | The effects of radiofrequency on skin:experimental study显示文摘 | ALVAREZ N ORTIZ L VICENTE V | 2008 | Lasers Surg Med2008，40，2： | 1 |
| 10 | Vision-based active safety system for automatic stopping显示文摘 | VICENTE M DAVID F L JORGE V | 2012 | Expert systems with applications2012，39，11： | 1 |
| 11 | The EXAMINATION (Everolimus-Eluting Stents Versus Bare-Metal Stents in ST-Segment Elevation Myocardial Infarction) Trial显示文摘 | Manel Sabaté Salvatore Brugaletta Angel Cequier Andrés I?iguez Antonio Serra Rosana Hernádez-Antolín Vicente Mainar Marco Valgimigli Maurizio Tespili Pieter den Heijer Armando Bethencourt Nicolás Vázquez Bianca Backx Patrick W. Serruys | 2013 | JACC: Cardiovascular Interventions2013，，： | 1 |
| 12 | Ascending aorta dissecting aneurysm in a teenager with isolated systemic hypertension显示文摘 | Manso P H Amaral F T Vicente W V | 2007 | Int J Cardiol2007，118，3： | 1 |
| 13 | Chronic hepatitis E in an immunoenmpetent patient显示文摘 | Gonzalez Talon AI Moreira Vicente V mateos Lindemann ML | 2011 | Gastroenterol Hepattol2011，34，6： | 1 |
| 14 | Early changes in the content of leaf polyamines during photoperiodic flowering in- duction in soybean 显示文摘 | Caffaro S V Vicente C | 1995 | Journal of Plant Physiology1995，145，56： | 1 |
| 15 | Weathering and decay of granitic rocks:its relation to their pore network显示文摘 | I(N)IGO A C VICENTE M A RIVES V | | 0，，09： | 1 |
| 16 | Female patients with breast carcinoma age 30 years and younger have a poor prognosis显示文摘 | Qinghua X Vicente V Vince K | 2001 | Cancer2001，92，10： | 1 |
| 17 | Hemodynamic effects of the combination of dexmedetomidine-fentanyl versus midazolam-fentanyl in children undergoing cardiac surgery with cardiopulmonary bypass显示文摘 | Klamt J G Vicente W V Garcia L V | 2010 | Rev BrasAnestesiol2010，60，1： | 1 |
| 18 | Treatment of metastatic melanoma B16FIO by the flavonoids tangeretin,rutin,and diosmin显示文摘 | Marttnez Conesa C Vicente Ortega V Y6fiez Gasc6n M J | 2005 | Journal of Agricultural and Food Chemistry2005，53，17： | 1 |
| 19 | Preparation of charcoal from cherry stones显示文摘 | CARLOS J D V MANUEL G C VICENTE G S | 2006 | Applied Surface Science2006，252，17： | 1 |
| 20 | Analytical and mineralogical studies of ore and impurities from a chromite mineral using X-ray analysis,electrochemical and microscopy techniques显示文摘 | RAMOS S S CARBO A D ADELANTADO J V VICENTE J P | 2008 | Talanta2008，74，5： | 1 |
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