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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | MeSH pesticide trace analysis using solid-phase extraction and gas chromatography with electron capture and tandem mass spectrometric detection in water samples显示文摘 | Martinez Vidal J L Pablos Espada M C Garrido Frenich A | | Jounal of Chromatography A0，，： | 2 |
| 3 | Determination of multiclass pesticides in food commodities by pressurized liquid extraction using GC-MS/MS and LC-MS/MS 显示文摘 | Frenich A G Salvador I M Vidal J L M Lopez T L | 2005 | Analytical and Bioanalytical Chemistry2005，33，78： | 1 |
| 4 | Development of fast screening methods for the analysis of veterinary drug residues in milk by liquid chromatography-triple quadrupole mass spectrometry显示文摘 | VIDAL J L M FRENICH A G AGUILERA-LUIZ M M | 2010 | Analytical and Bioanalytical Chemistry2010，397，7： | 1 |
| 5 | Malic enzyme 1 genotype is associated with backfat thickness and meat quality traits in pigs 显示文摘 | Vidal O Varona L Oliver M A | 2005 | Anim Genet2005，37，： | 1 |
| 6 | Chemical force titration of plasma polymer - modified PDMS substrates by using plasma polymer- modified AFM tips显示文摘 | Geissler A Vallat M F Vidal L | 2008 | Langmuir2008，24，： | 1 |
| 7 | Gas chromatographic method and whole body dosimetry for assessing dermal exposure of greenhouse applicators tochlorpyrifos-methyl and fenitrothion 显示文摘 | CA_NO M L C VIDAL J L M GONZALEZ F J E | 2000 | Analytica Chimica Acta2000，423，9： | 1 |
| 8 | Behaviour of molecular weight distribution for the liquid fraction of pig slurry treated by anaerobic digestion 显示文摘 | Rodirguez D C Belmonte M Penuela G Campos J L Vidal G | 2011 | Environmental Technology2011，33，4： | 1 |
| 9 | A class I KNOX gene from the palm species Elaeis guineensis (Arecaceae) is associated with meristem function and a distinct mode of leaf dissection显示文摘 | Jouannic S Collin M Vidal B Verdeil J L | 2007 | New phytologist2007，174，3： | 1 |
| 10 | Simultaneous presentation of silicone and silica granuloma a case report显示文摘 | Pinentel L Bamadas M Vidal D | 2002 | Dermatology2002，205，2： | 1 |
| 11 | Potential biomarkers of trichloroethylene and toluene exposure in Corbicula fluminea 显示文摘 | VIDAL M L BASSERES A NARBONNE J F | 2001 | Environmental Toxicology and Pharmacology2001，9，3： | 1 |
| 12 | High-throughput determination of pesticide residuesin food commodities by use of ultra-performance liquid chromatography-tandem mass spectrometry显示文摘 | FRENICH A G VIDAL J L M MONTORO E A GONZALEZ R | 2008 | Anal Bioanal Chem2008，390，3： | 1 |
| 13 | Identification of carcass and meat quality quantitative trait loci in a Landrace pig popu- lation selected for growth and leanness 显示文摘 | Vidal O Noguera J L Amills M | 2005 | J Anita Sci2005，83，2： | 1 |
| 14 | Individual voltage balancing strategy for PWMcascaded H-bridge converter based STATCOM显示文摘 | Barrena J A Marroyo L Vidal M A R | 2008 | IEEE Transactions on Industrial Electronics2008，55，1： | 1 |
| 15 | Multiclass method for fast determination of veterinary drug residues in baby food by ultra-high-performance liquid chromatography-tandem mass spectrometry 显示文摘 | AGUILERA-LUIZ M M MARTINEZ VIDAL J L ROMERO-GONZALEZ R | 2012 | Food Chemistry2012，132，4： | 1 |
| 16 | Determination of carbendazim,thiabendazole and fuberidazole using a net analyte signal-based method 显示文摘 | Galera M M Zamora D P Vidal J L M | 2003 | Talanta2003，59，6： | 1 |
| 17 | Determination of cypermethrin, fenvalerate and cis-andtrans-permethrin in soil and ground water by high-performance liquid chromatography using partial least-squares regression显示文摘 | Galera M Vidal J L M | 1996 | J Chromatography A1996，727，： | 1 |
| 18 | A study on the TNF-alpha system in Caucasian Spanish patients with al-coholic liver disease显示文摘 | Auguet T Vidal F López-Dupla M | | 0，，1： | 1 |
| 19 | Monitoring multi-class pesticide residues in fresh fruits and vegetables by liquid chromatography with tandem mass spectrometry显示文摘 | FRENICH A G VIDAL M J L | 2004 | Journal of Chromatography A2004，1048，： | 1 |
| 20 | Polymorphism of DECRI and its association with carcass and meat quality traits显示文摘 | Amills M Vidal O Varona L | 2005 | J Anita Sci2005，83，： | 1 |
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