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| 1 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 2 | 在肝 preconditioning 的最近的进展: 甲状腺荷尔蒙, n-3 长链的多元不堡和丰满的酸和熨斗显示文摘 Liver preconditioning (PC), defined as an enhanced tolerance to injuring stimuli induced by previous specific maneuvers triggering beneficial functional and molecular changes, is of crucial importance in human liver transplantation and major hepatic resection. For these reasons, numerous PC strategies have been evaluated in experimental models of ischemia-reperfusion liver injury, which have not been transferred to clinical application due to side effects, toxicity and difficulties in implementation, with the exception of the controversial ischemic PC. In recent years, our group has undertaken the assessment of alternate experimental liver PC protocols that might have application in the clinical setting. These include thyroid hormone (T3), n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA), or iron, which suppressed liver damage due to the 1 h ischemia-20 h reperfusion protocol. T3, n-3 LCPUFA and iron are hormetic agents that trigger biologically beneficial effects in the low-dose range, whose multifactorial mechanisms of action are discussed in the work. | Virginia Fernández Gladys Tapia Luis A Videla | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 3 | Misregulation of PPAR functioning and its pathogenic Consequences associated with nonalcotolic fatty liver disease in human obesity显示文摘 | Videla L A Pettinelli P | 2012 | 2012:1074342012，，10： | 1 |
| 4 | A tritrophic analysis of host preference and performance in a polyphagous leafminer显示文摘 | Videla M Valladares G Salvo A | 2006 | Entomologia Experimentalis et Applicata2006，121，： | 1 |
| 5 | A Multicenter, Randomized, Clinical Trial of Hormonal Therapy in the Prevention of Rebleeding From Gastrointestinal Angiodysplasia显示文摘 | Félix Junquera Faust Feu Michel Papo Sebastián Videla José Ramón Armengol Josep Mar??a Bordas Esteban Saperas Josep M. Piqué Juan-Ramón Malagelada | 2001 | Gastroenterology2001，，5： | 1 |
| 6 | Acute lower respiratory infections due to respiratory syncytial virus and adenovirus among hospitalized children from Argentina显示文摘 | Carballal G Misirlian A | 1998 | Clin Diagn Virol1998，10，1： | 1 |
| 7 | Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to non-alcoholic fatty liver disease显示文摘 | Videla L A Rodrigo R Araya J | 2004 | Free Radic Biol Med2004，37，： | 1 |
| 8 | Alcohol ingestion, liver glutathione and lipoperoxidation, metabolic interrelations and pathologicalimplications 显示文摘 | Videla LA Valenzuela A | 1982 | Life Sci1982，31，： | 1 |
| 9 | Major changes in the G protein of human respiratory syncytial virus isolates introduced by a duplication of 60 nucleotides显示文摘 | Trento A Galiano M Videla C | 2003 | J Gen Virol2003，84，： | 1 |
| 10 | The inhibition of corrosion of S30403 stainless steel by a naturally occurring catecholic polymer显示文摘 | Dexter S C Duquette D J Siebert O W Videla H A | 1991 | Corrosion1991，47，4： | 1 |
| 11 | Oxidative stressrelated parameters in the liver of non-alcoholic fatty liver disease patients显示文摘 | Videla L A Rodrigo R Orellana M | 2004 | Clin Sci (Lond)2004，106，3： | 1 |
| 12 | Microbially induced corrosion: an updated overview 显示文摘 | Videla H A | 2001 | Intemational Biodeterioration & Biodegradation2001，48，14： | 1 |
| 13 | Adenovirus type 7 associated with severe and fatal acute lower respiratory infection in Argentine children 显示文摘 | Carballal C Videla C Misirlian A | 2002 | BMC Pediatr2002，2，1： | 1 |
| 14 | Alcohol ingestion liver glutathione and lipidperoxidation : metabolic interrelation and pathological implications显示文摘 | Videla LA Valenzuela A | 1982 | Life Sciences1982，31，22： | 1 |
| 15 | An innovative method for preventing biocorrosion through microbial adhesion inhibition显示文摘 | Patricia S Guiamet Sandra G Gomez de Saravia Hector A Videla | 1999 | International Bioddeterioration & Biodegradeation1999，43，： | 1 |
| 16 | Role of iron-reducing bacteria in cor- rosion and protection of carbon steel显示文摘 | Herrera L K Videla H A | 2009 | International Biodete- flotation and Biodegradation2009，63，7： | 1 |
| 17 | Sizing particles by backscattering spectroscopy and Fourier analysis显示文摘 | F A Videla D Schinca L B Scaffardi | 2006 | Appl Opt2006，45，4： | 1 |
| 18 | Alcohol ingestion, liver glutathione and li- poperoxidation, metabolic interrelations and pathological implica tions显示文摘 | Videla LA Valenzuela A | 1982 | Life Sci1982，31，22： | 1 |
| 19 | Adenovirus type7 associated with severe and fatal acute lower respiratory infections in Argentine children显示文摘 | Carballal G Videla C Misirlian A | 2002 | BMC Pediatr2002，16，2： | 1 |
| 20 | Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients显示文摘 | Videla L A Rodrigo R Orellana M | 2004 | Clin Sci2004，106，3： | 1 |
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