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| 1 | Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study显示文摘AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic patients.METHODS This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours.RESULTS Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction. | Charlotte Nicolas Amelie Le Gouge Louis d’Alteroche Jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing Jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud Louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau Jean-Marc Perarnau STIC-TIPS group | 2017 | World Journal of Hepatology2017，9，27： | 6 |
| 2 | Simulation and Visualisation of Functional Landscapes:Effects of the Water Resource Competition Between Plants显示文摘Vegetation ecosystem simulation and visualisation are challenging topics involving multidisciplinary aspects. In this paper,we present a new generic frame for the simulation of natural phenomena through manageable and interacting models.It focuses on the functional growth of large vegetal ecosystems,showing coherence for scales ranging from the individual plant to communities and with a particular attention to the effects of water resource competition between plants.The proposed approach is based on a model of plant growth in interaction with the environmental conditions. These are deduced from the climatic data (light,temperature,rainfall) and a model of soil hydrological budget.A set of layers is used to store the water resources and to build the interfaces between the environmental data and landscape components:temperature,rain,light,altitude,lakes,plant positions,biomass,cycles,etc.At the plant level,the simulation is performed for each individual by a structural-functional growth model,interacting with the plant's environment.Temperature is spatialised,changing according to altitude,and thus locally controls plant growth speed.The competition for water is based on a soil hydrological model taking into account rainfalls,water runoff, absorption,diffusion,percolation in soil.So far,the incoming light radiation is not studied in detail and is supposed constant.However,competition for light between plants is directly taken into account in the plant growth model.In our implementation,we propose a simple architecture for such a simulator and a simulation scheme to synchronise the water resource updating (on a temporal basis) and the plant growth cycles (determined by the sum of daily temperatures). The visualisation techniques are based on sets of layers,allowing both morphological and functional landscape views and providing interesting tools for ecosystem management.The implementation of the proposed frame leads to encouraging results that are presented and illustrate simple academic cases. | Vincent Le Chevalier Marc Jaeger 梅兴 Paul-Henry Cournède | 2007 | Journal of Computer Science & Technology2007，22，6： | 2 |
| 3 | Common polymorphism in the PNPLA3 /adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease显示文摘 | Eric Trépo Thierry Gustot Delphine Degré Arnaud Lemmers Laurine Verset Pieter Demetter Romy Ouziel Eric Quertinmont Vincent Vercruysse Leila Amininejad Pierre Deltenre Olivier Le Moine Jacques Devière Denis Franchimont Christophe Moreno | 2011 | Journal of Hepatology2011，，4： | 2 |
| 4 | Controlling the gelation temperature of biomimetic polyisocyanides显示文摘Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature(LCST) is often sharp, which allows for a wide range of smart material applications.At the LCST, oligo(ethylene glycol)-substituted polyisocyanides(PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol(EG) tails; every EG group increases the LCSTand thus the gelation temperature by nearly 30 ℃. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 ℃ and 60 ℃and, consequently, tune the mechanical properties of the PIC gels. | Paul H.J. Kouwer Paula de Almeida Onno ven den Boomen Zaskia H. Eksteen-Akeroyd Roel Hammink Maarten Jaspers Stijn Kragt Mathijs F.J. Mabesoone RoelandJ.M. Nolte Alan E. Rowan Martin G.T.A. Rutten Vincent A.A. Le Sage Daniel C. Schoenmakers Chengfen Xing Jialiang xu | 2018 | Chinese Chemical Letters2018，29，2： | 2 |
| 5 | Prominent and Persistent Extraneural Infection in Human PrP Trausgenic Mice Infected with Variant CJD显示文摘 | Vincent Beringue Annick Le Dur Philippe Tixador | 2008 | PLoS ONF2008，，1： | 1 |
| 6 | High Prognostic Impact of Flow Cytometric Minimal Residual Disease Detection in Acute Myeloid Leukemia: Data From the HOVON/SAKK AML 42A Study显示文摘 | Monique Terwijn Wim L.J. van Putten Angèle Kelder Vincent H.J. van der Velden Rik A. Brooimans Thomas Pabst Johan Maertens Nancy Boeckx Georgine E. de Greef Peter J.M. Valk Frank W.M.B. Preijers Peter C. Huijgens Angelika M. Dr?ger Urs Schanz Mojca Jongen | 2013 | Journal of Clinical Oncology2013，，31： | 1 |
| 7 | Optimal cooling design in injection moulding process–A new approach based on morphological surfaces显示文摘 | Alban Agazzi Vincent Sobotka Ronan Le Goff | 2013 | Applied Thermal Engineering2013，52，1： | 1 |
| 8 | Mutations in the Gene Encoding Filamin A as a Cause for Familial Cardiac Valvular Dystrophy显示文摘 | Florence Kyndt Jean-Pierre Gueffet Vincent Probst Philippe Jaafar Antoine Legendre Fran?oise Le Bouffant Claire Toquet Estelle Roy Lesley McGregor Sally Ann Lynch Ruth Newbury-Ecob Vinh Tran Ian Young Jean-Noel Trochu Hervé Le Marec Jean-Jacques Schott | 2007 | Circulation2007，，1： | 1 |
| 9 | Inflammatory response to cardiopulmonary bypass显示文摘 | Wan S Le Clerc JL Vincent JL | 1997 | Chest1997，112，3： | 1 |
| 10 | A two-dimensional shallow ice-flow model of Glacier de Saint-Sorlin,France显示文摘 | Le Meur E Vincent C | 2003 | Journal of Glaciology2003，49，167： | 1 |
| 11 | Effects of temperature on the growth of pollack ( Pollachius pollachius ) juveniles显示文摘 | J. Person-Le Ruyet V. Buchet B. Vincent H. Le Delliou L. Quéméner | 2005 | Aquaculture2005，，2： | 1 |
| 12 | Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory element s显示文摘 | Vincent SIS) Norris DP Le G | 2004 | Mech Dev2004，121，11： | 1 |
| 13 | Sepsis in European intensive care units: Results of the SOAP study显示文摘 | Jean-Louis Vincent Yasser Sakr Charles L. Sprung V Marco Ranieri Konrad Reinhart Herwig Gerlach Rui Moreno Jean Carlet Jean-Roger Le Gall Didier Payen | 2006 | Critical Care Medicine2006，，2： | 1 |
| 14 | Neuroprotective Effects of Dexmedetomidine against Glutamate Agonist-induced Neuronal Cell Death Are Related to Increased Astrocyte Brain-derived Neurotrophic Factor Expression显示文摘 | Vincent Degos Tifenn Le charpentier Vibol Chhor Olivier Brissaud Sophie Lebon Leslie Schwendimann Nathalie Bednareck Sandrine Passemard Jean Mantz Pierre Gressens | 2013 | Anesthesiology2013，，5： | 1 |
| 15 | The SSN ontology of the W3C semantic sensor network incubator group显示文摘 | Michael Compton Payam Barnaghi Luis Bermudez Raúl García-Castro Oscar Corcho Simon Cox John Graybeal Manfred Hauswirth Cory Henson Arthur Herzog Vincent Huang Krzysztof Janowicz W. David Kelsey Danh Le Phuoc Laurent Lefort Myriam Leggieri Holger Neuhaus A | 2012 | Web Semantics: Science Services and Agents on the World Wide Web2012，，： | 1 |
| 16 | Postprandial plasma ghrelin is suppressed proportional to meal calorie content in normal-weight but not obese subjects显示文摘 | Le Roux CW Patterson M Vincent RP | | 0，，： | 1 |
| 17 | Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS显示文摘 | Anne-Sophie Brunel Jacques Reynes Edouard Tuaillon Pierre-Alain Rubbo Olivier Lortholary Brigitte Montes Vincent Le Moing Alain Makinson | 2012 | AIDS2012，，16： | 1 |
| 18 | SCN5A Mutations and the Role of Genetic Background in the Pathophysiology of Brugada Syndrome显示文摘 | Vincent Probst Arthur A.M. Wilde Julien Barc Frederic Sacher Dominique Babuty Philippe Mabo Jacques Mansourati Solena Le Scouarnec Florence Kyndt Cedric Le Caignec Pascale Guicheney Laetitia Gouas Juliette Albuisson Paola G. Meregalli Hervé Le Marec Hanno | 2009 | Circulation: Cardiovascular Genetics2009，，6： | 1 |
| 19 | Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model显示文摘 | Vincent E. de Meijer Hau D. Le Jonathan A. Meisel M. Reza Akhavan Sharif Amy Pan Vania Nosé Mark Puder | 2010 | Metabolism2010，，8： | 1 |
| 20 | Out-of-plane (SH) soil-structure interaction: a shear wall with rigid and flexible ring foundation显示文摘Soil-structure interaction(SSI) of a building and shear wall above a foundation in an elastic half-space has long been an important research subject for earthquake engineers and strong-motion seismologists.Numerous papers have been published since the early 1970s;however,very few of these papers have analytic closed-form solutions available.The soil-structure interaction problem is one of the most classic problems connecting the two disciplines of earthquake engineering and civil engineering.The interaction effect represents the mechanism of energy transfer and dissipation among the elements of the dynamic system,namely the soil subgrade.foundation,and superstructure.This interaction effect is important across many structure,foundation,and subgrade types but is most pronounced when a rigid.superstructure is founded on a relatively soft lower foundation and subgrade.This effect may only be ignored when the subgrade is much harder than a flexible superstructure:for instance a flexible moment frame superstructure founded on a thin compacted soil layer on top of very stiff bedrock below.This paper will study the interaction effect of the subgrade and the superstructure.The analytical solution of the interaction of a shear wall,flexible-rigid foundation,and an elastic halfspace is derived for incident SH waves with various angles of incidence.It found that the flexible ring(soft layer)cannot be used as an isolation mechanism to decouple a superstructure from its substructure resting on a shaking half-space. | Thang Le Vincent W. Lee Hao Luo | 2016 | Earthquake Science2016，29，1： | 1 |
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