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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 3 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 4 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 5 | Critical evaluation of the literature data on beta-alumina and related phases, 1, Phase equilibria and characterization of beta-alumina phase 显示文摘 | DE VRIES R C RATH W L | 1969 | J Am Ceram Soc1969，52，7： | 1 |
| 6 | Intensive laparoscopic training:the impact of a simplified pelvic-trainer model for the urethrovesical anastomosis on the learning curve显示文摘 | Poulakis V Witzsch U De Vries R | 2006 | World J Urol2006，24，3： | 1 |
| 7 | Measles vaccination of nonhuman primates provides partial protection against infection with canine distemper vi- rus显示文摘 | de Vries R D Ludlow M Verburgh R J | 2014 | J Virol2014，88，8： | 1 |
| 8 | Rigging the lobbying process: An application of the all-pay auction显示文摘 | Baye M R Kovenock D de Vries C G | 1993 | The American Economic Review1993，83，1： | 1 |
| 9 | Structural protein requirements in equine arteritis virus assembly显示文摘 | Wieringa R de Vries A A vander Meulen J | 2004 | J Virol2004，78，13： | 1 |
| 10 | Dendritic-cell immunothera- py:from ex vivo loading to in vivo targeting显示文摘 | Taeken PJ de Vries I J Torensma R | 2007 | Nat Rev Immunol2007，7，10： | 1 |
| 11 | Synthesis and in vivo antitumor activity of poly (L-glutamic acid) conjugates of 20 (S)-camptothecin显示文摘 | BHATT R VRIES P D TULINSKY J | 2003 | J Med Chem2003，46，1： | 1 |
| 12 | The development of two tooling concepts for the production of composite sine-wave beams显示文摘 | Thuis H G S J de Vries H R J | 1995 | Composite Structures1995，32，： | 1 |
| 13 | Leadership group coaching in action: The Zen of creating high performance teams显示文摘 | Kets de Vries M F R | 2005 | Academy of Management2005，19，1： | 1 |
| 14 | Plasma apolipoproteinM is reduced in metabolic syndrome but does not predict intima media thickness显示文摘 | DULLAART R P PLOMGAARD P DE VRIES R | 2009 | Clin Chim Acta2009，406，： | 1 |
| 15 | Evidence based selection of housekeeping genes显示文摘 | de Jonge H J Fehrmann R S de Bont E S Hofstra R M Gerbens F Kamps W A de Vries E G van der Zee A G te Meerman G J ter Elst A | | 0，，： | 1 |
| 16 | An integrated approachfor visual analysis of a multisource moving objectsknowledge base 显示文摘 | Willems N van Hage W R de Vries G | 2010 | International Journal of Geographical InformationScience2010，24，10： | 1 |
| 17 | Moisture movement in porous materials under temperature gradients显示文摘 | PHILIP J R DE VRIES D A | 1957 | Transactions American Geophysical Union1957，38，2： | 1 |
| 18 | The all-pay auction with complete information 显示文摘 | Baye M R Kovenock D de Vries C G | 1996 | Economic Theory1996，8，： | 1 |
| 19 | Dendritic-cell immtmotherapy: from ex vivo loading to in vivo targeting 显示文摘 | TACKEN P J DE VRIES I J TORENSMA R | 2007 | Nat Rev Immunol2007，7，10： | 1 |
| 20 | Chemical an thermal stability of ferulic acid (feruloyl) esterases from Aspergillus 显示文摘 | Faulds C B Aliwan F O De Vries R P | 1998 | Progress in Biotechnology1998，，15： | 1 |
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