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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Reporting physi- sorption data for gas/solid systems with special reference to the determination of surface area and porosity显示文摘 | Sing K S W Everett D H Haul R A W | 1985 | Pure and Applied Chemistry1985，57，4： | 1 |
| 3 | Heart rate analysis in normal subjects of various age groups 显示文摘 | Acharya U R Kannathal N Sing O W | 2004 | Biomed Eng Online2004，3，1： | 1 |
| 4 | Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity显示文摘 | Sing K S W | 1985 | Pure and Applied Chemistry1985，57，4： | 1 |
| 5 | Adsorption surface area and porosity显示文摘 | Gregg S J Sing K S W | 1967 | Journal of the Electrochemical Society1967，114，11： | 1 |
| 6 | Reporting Physisorption Data for Gas/Solid Systems with Special Reference to the Determination of Surface Area and Porosity显示文摘 | Sing K S W Everett D H Haul R A W Moscou L Pierotti R A Rouquerol J Siemieniewska T | 1985 | Pure & Appl Chem1985，57，4： | 1 |
| 7 | Reporting physisorption data for gas/solid system显示文摘 | Sing K S W Everett D H Haul R A W | 1985 | Pure & Applied Chemistry1985，57，4： | 1 |
| 8 | Arylalkylidene Rhodanine with Bulky and Hydrophobic Functional Group as Selective HCV NS3 Protease Inhibitor显示文摘 | Lee C L Yeo S L | 2001 | Bio Med Chem Lett2001，11，： | 1 |
| 9 | The use of physisorption for the characterization of microporous carbons 显示文摘 | Kenneth S W Sing | 1989 | Carbon1989，27，1： | 1 |
| 10 | Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity显示文摘 | Sing K S W Everett D H Hall R A W | 1985 | Pure & Appl Chem1985，57，： | 1 |
| 11 | Reporting Physisorption Data for Gas/Solid Systems with Special Reference to the Determination of Surface Area and Porosity显示文摘 | Sing K S W Everett D H Haul R A W | 1985 | Pure and Applied Chemistry1985，57，： | 1 |
| 12 | Reporting physisorption data for gas/ solid systems with special reference to the determination of surface area and porosity (Recommendations 1984 ) 显示文摘 | Kenneth S W Sing | 1985 | Pure and Applied Chemistry1985，57，4： | 1 |
| 13 | Reporting physisorption data for gas/solid systems, with special reference to the determination of surface area and porosity 显示文摘 | SING K S W EVERETT D H HAUL R A W | | Pure Appl Chem0，57，60： | 1 |
| 14 | Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity显示文摘 | SING K S W EVERETT D H HAUL R A W MOSENU L PIEROTrI R A ROUQUEROL J T | 1985 | Pure Appl Chem1985，57，4： | 1 |
| 15 | Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity 显示文摘 | Sing K S W | 1985 | Pure and Applied Chemis- try1985，57，4： | 1 |
| 16 | Reporting physi sorption data area and porosity显示文摘 | Sing K S W Everett D H Haul R A W | 1985 | Pure and Applied Chemis- try1985，57，4： | 1 |
| 17 | Reporting physisorption data for gas/solid systems with special reference to determination of surface area and porosity 显示文摘 | SING K S W EVERETT D H HAUL R A W | 1985 | Pure and Applied Chemistry1985，57，4： | 1 |
| 18 | Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity (Recommendations 1984)显示文摘 | SING K S W EVERETT D H HAUL R A W MOSCOU L PIEROTTI R A ROUQUEROL J SIEMIENIEWSKA T | 1985 | Pure Appl Chem1985，57，4： | 1 |
| 19 | Engineering behavior of stabilized peat soils显示文摘 | SING W L HASHIM R ALI F H | 2008 | Eur J Sci Res2008，21，4： | 1 |
| 20 | Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity (Recommendations 1984)显示文摘 | Sing K S W Everett D H Haul R A W | 1985 | Pure & Appl Chem1985，57，4： | 1 |
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