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| 1 | MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models显示文摘激活 mitogen 的蛋白质 kinase (MAPK ) 的激活小径在癌症是经常的。药发展努力在这条小径集中于 kinases,最尤其是在皇家空军和 MEK 上。我们这里证明 MEK 抑制激活通过 DUSP4 的抑制发信号的 JNK6 月,导致她的受体酷氨酸 Kinases 的激活。这面对药刺激 MAPK 小径,从而弄钝 MEK 抑制的效果。失去了 MAP3K1 或 MAP2K4 的癌症没能因而激活 JNK-JUN. ,在 MAP3K1 或 MAP2K4 的 loss-of-function 变化由在 MEK 抑制之上停用 JNK-JUN-mediated 反馈循环授与敏感到 MEK 抑制。在 168 个耐心的导出的异种皮移植(PDX ) 肿瘤的一块面板, MAP3K1 和 MAP2K4 变化地位是对 MEK 抑制的反应的一个强壮的预言者。我们的调查结果建议在 MAP3K1 或 MAP2K4 有变化的癌症,在胸,前列腺和冒号的肿瘤经常,可以对 MEK 禁止者作出回应。我们的调查结果也建议 MAP3K1 和 MAP2K4 是在有 MEK 禁止者的联合的潜在的药目标,尽管有他们被肿瘤 suppressor 基因编码的事实。 | Zheng Xue Daniel J. Vis Alejandra Bruna Tonci Sustic Sake van Wageningen Ankita Sati Batra Oscar M. Rueda Evert Bosdriesz Carlos Caldas Lodewyk F. A. Wessels Rene Bernardt | 2018 | Cell Research2018，28，7： | 5 |
| 2 | Landscape fragmentation by urbanization in the Netherlands: options and ecological consequences显示文摘1Introduction:thestudyareaFig1ThestudyareaTheeconomicactivitiesoftheNetherlandsareconcentratedinthewestofthecountry,thesoca... | W. Bert. Harms Department of Landscape Ecology, Winand Staring Centre DLO, Wageningen, The Netherlands | 1999 | Journal of Environmental Sciences1999，11，2： | 5 |
| 3 | CO2和He在阳泉煤CH4饱和基质煤柱中的渗流特性显示文摘利用自行设计的自约束渗透装置,采用热导检测器在线跟踪穿透实验过程中CO2或He的渗透信号,在40℃条件下,对比研究了CO2和He在阳泉煤CH4饱和基质煤柱(φ6×13mm)中的渗透行为,讨论了煤对气体的吸附或吸取作用及孔隙气压对渗透率的影响。研究表明,有别于煤对He的作用,在CO2和CH4交替渗透时,不同的CH4吹扫时间,对应于不同的CO2初始穿透时间。CO2穿透后被CH4吹扫36h,在煤柱中仍有残留,表明煤对CO2具有相对较强的吸着作用。He在煤柱中穿透后没有明显残留,并且He在测试煤柱中渗透率明显大于CO2的渗透率。在测试条件下,气体交替渗透多次的稳定渗透率无明显变化,表明煤柱的结构没有发生显著变化。由于孔壁效应、煤基质膨胀、吸附边界层等因素的存在,使得气体渗透率随孔隙气体压力的增加而降低。 | 汤放新 杨建丽 肖勇 刘振宇 Niels van Wageningen | 2011 | 燃料化学学报2011，39，2： | 2 |
| 4 | Experimental study of gas and water transport processes in the inter-cleat (matrix) system of coal: Anthracite from Qinshui Basin, China显示文摘 | Fengshuang Han Andreas Busch Niels van Wageningen Jianli Yang Zhenyu Liu Bernhard M. Krooss | 2009 | International Journal of Coal Geology2009，，2： | 2 |
| 5 | Leaf area development, dry weight accumulation and solar energy conversion efficiencies of Phaseolus vulgaris L. under different soil moisture levels near Nairobi, Kenya显示文摘Leaf area development, dry weight accumulation and solar energy conversion efficiencies of Phaseolus vulgaris L. cv GLP\|2 under two soil moisture levels in two contrasting seasons near Nairobi, Kenya were investigated. The experiment confirms that dry weights and yields of Phaseolus vulgaris are limited by a drought induced decrease in leaf area, leading to less radiation interception as a source for assimilation. However, photosynthetic efficiency in Phaseolus vulgaris also appears to decrease and to contribute to these effects. Finally, an even larger decreases of economic efficiency as obtained in the second season, where stress lasted much later into the season, reveals that such a drought also limits considerably the partitioning and translocation of assimilates to the seeds of Phaseolus vulgaris. The efficiencies obtained are in line with the better literature data for other crops. | M.M. Muniafu 1* , J.N.M. Macharia\+1, C.J.Stigter\+2,G.L.Coulson\+3 (1.Department of Botany, University of Nairobi, Nairobi, Kenya 2. TTMI\|Project,Department of Meteorology, Wageningen Agricultural University,Duivendaal 2, 6701 AP Wageningen, Net | 1999 | Journal of Environmental Sciences1999，11，4： | 2 |
| 6 | Sequencing and analysis of genes involed in the biosynthesis of a vancomycin group antibiotic显示文摘 | Wageningen A M Rirkpatrick P N Williams D H | 1998 | Chem boil1998，5，3： | 1 |
| 7 | Production of gas from coal seams in the Upper Silesian Coal Basin in Poland in the post-injection period of an ECBM pilot site显示文摘 | Van Bergen F Krzystolik P van Wageningen N | 2009 | International Journal of Coal Geology2009，77，12： | 1 |
| 8 | Calixarene-Based (Hemi)carcerands and Careeplexes- Synthesis, Functionalization, and Molecular Modeling Study显示文摘 | van Wageningen A M A Timmerrnan P van Duynhoven J P M | 1997 | Chem Eur1997，3，： | 1 |
| 9 | Dynamic flow in a Kenics static mixer: An assessment of various CFD methods显示文摘 | w F C van Wageningen D Kandhai R F Mudde | 2004 | AIChE J2004，，50： | 1 |
| 10 | Genetic Mapping of QTLs Associated with Growth Vigour in Rose显示文摘 | Wageningen U R Plant Res Int | 2003 | Acta Horticuhurae2003，612，： | 1 |
| 11 | High prevalence of hypogonadotropic hypogonadism in men referred for obesity treatment显示文摘 | Hofstra J Loves S van Wageningen B | 2008 | Netherlands Journal of Medicine2008，66，3： | 1 |
| 12 | Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic显示文摘 | van Wageningen A M Kirkpatrick P N Williams D H | | 0，，03： | 1 |
| 13 | Sequencing and analysis of genes involved in the biosynthesis of a vancomyein group antibiotic显示文摘 | van Wageningen A M Kirkpatrick P N Williams D H | 1998 | Chem Biol1998，5，3： | 1 |
| 14 | High prevalence of hypogonadotropic hypogonadism in men referred for obesity treatment显示文摘 | Hofstra J Loves S van Wageningen B | 2008 | Neth J Med2008，66，3： | 1 |
| 15 | Evidence for glutamatergic neurotransmission in cognitive control in an auditory attention task显示文摘 | Van Wageningen H Jψrgensen HA Specht K | | 0，，03： | 1 |
| 16 | Dynamic flow in a Kenics static mixer:An assessment of various CFD methods显示文摘 | W.F.C.van Wageningen D.Kandhai R.F.Mudde | | 0，，： | 1 |
| 17 | Comparison Between Amy lose-free and Amylose Containing Potato Starches显示文摘 | Visser RGF Suurs LCJM Wageningen | 1997 | Starch/St(a)rke1997，，49： | 1 |
| 18 | Some Physicochemical Properties of Amylose-free Potato Starch显示文摘 | Visser RGF Suurs LCJM Wageningen | 1997 | Starch/St(a)rke1997，，49： | 1 |
| 19 | Production of Gas from Coal Seams in the Upper Sile sian Coal Basin in Polandin the Post-injection Period of an ECBM Pilot Site显示文摘 | VAN BERGEN F KRZYSTOLIK P VAN WAGENINGEN N | 2009 | International Journal of Coal Geology2009，77，12： | 1 |
| 20 | Genetic mapping of QTLs associated with growth vigour in rose显示文摘 | Yan ZF Wageningen UR | 2003 | Acta Horiculturae2003，612，： | 1 |
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