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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | New insights into cyclosporine A nephrotoxicity by proteome analysis 显示文摘 | Wahl D Arce A | 1998 | Electrophoresis1998，19，： | 1 |
| 3 | Eigenvector Method for Maximum likelihood Estimation of Phase Errors in Synthetic-aperture radar Imagery 显示文摘 | JAKOWATZ C V WAHL D E | 1993 | Journal of the Optical Society of America A: Optics Image Science and Vision1993，10，25： | 1 |
| 4 | How early is early laparoscopic treatment of acute cholecystitis 显示文摘 | Madan AK Aliabadi - Wahle S Tesi D | 2002 | Am J Surg2002，183，3： | 1 |
| 5 | Shear stresses in honeycomb sandwich plates: analytical solution, finite element method and experimental verification 显示文摘 | Wahl L Maas S Waldmann D | 2012 | Journal of Sandwich Structmes & Materials2012，14，： | 1 |
| 6 | Phase gradient autofocus-a robust tool for high resolution SAR phase correction显示文摘 | Wahl D E Eichel P H Ghiglia D C | 1994 | IEEE Trans on AES1994，30，3： | 1 |
| 7 | Improved intymed- ullary nail interlocking in osteoporotic bone显示文摘 | Ito K Hungerbuhler R Wahl D | 2001 | J Orthop Trauma2001，15，12： | 1 |
| 8 | Phase gradient autofocus-- A robust tool high resolution SAR phase correction显示文摘 | Wahl D E Eichel P H Ghiglia D C | 1994 | IEEE Transations on Aerospace and Electronic Systems1994，30，3： | 1 |
| 9 | Phase gradient autofocus-a robust tool for high resolution SAR phase correction显示文摘 | Wahl D E Eichel P H Ghiglia D C | 1994 | IEEE Trans on GRS1994，30，3： | 1 |
| 10 | Kinetic mech- anism of human DNA ligase I reveals magnesium- dependent changes in the rate-limiting step that com- promise ligation efficiency显示文摘 | Taylor M R Conrad J A Wahl D | 2011 | J Biol Chem2011，286，23： | 1 |
| 11 | Phase gradient auto-focus-a robust tool for high resolution SAR phase correction 显示文摘 | WAHL D E EICHEL P H GHIGLLA D C | 1994 | IEEE Transactions on aerospace and electronic system1994，30，3： | 1 |
| 12 | Nonpoint source runoff modeling a comparison of a forested watershed and an urban watershed on the South Carolina Coast显示文摘 | CORBETT C W WAHL M PORTER D E | 1997 | Journal of Experimental Marine Biology and Ecology1997，213，1： | 1 |
| 13 | Phase gradient autofocus a robust tool for high resolution SAR phase correction显示文摘 | Wahl D E Eichel P H Ghiglia D C | 1994 | IEEE Trans on AES1994，30，3： | 1 |
| 14 | Thrombinography shows ac quired resistance to activated protein C in patients with lupus an- ticoagulants显示文摘 | Regnault V Beguim S Wahl D et ai | 2003 | Thromb Haemost2003，89，2： | 1 |
| 15 | Quantifying the hydraulic performance of treatment wetlands using the moment index显示文摘 | Wahl M D Browna L C Soboyejoa A O | 2010 | Ecological Engineering2010，36，： | 1 |
| 16 | Not all instability training devices en- hance muscle activation in highly resistance-trained individuals 显示文摘 | WAHL M J BEHM D G | 2008 | J Strength Cond Res2008，22，4： | 1 |
| 17 | Collagenhydroxyapatite composites for hard tissue repair显示文摘 | WAHL D A CZERNUSZKA J T | 2006 | Eur Cell Mater2006，28，11： | 1 |
| 18 | How early is early laparoscopic treatment of cholecystitis显示文摘 | Madan A K Aliabadi Wahle S Tesi D | | 0，，03： | 1 |
| 19 | Plant phenolics in the pre- vention and treatment of cancer显示文摘 | Wahle KW Brown I Rotondo D | 2010 | Adv Exp Med Biol2010，698，： | 1 |
| 20 | Phase Gradient Autofocus -A Robust Tool for High Resolution SAR PhaseCorrection 显示文摘 | Wahl D E Eichel P H Ghiglia DC | 1994 | IEEE Transactions on Aerospace and Electronic Systems(S0018-9251)?1994，30，3： | 1 |
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